2021
DOI: 10.1016/j.cub.2020.10.050
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Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness

Abstract: Highlights d Activation of POA Tac1 neurons promoted and stabilized wake over NREM and REM sleep d Wakefulness caused by POA Tac1 activation is not due to increased anxiety d POA Tac1 activation enhanced emergence from isoflurane and sevoflurane anesthesia d The same neurons modulating endogenous arousal may sculpt states of anesthesia

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Cited by 35 publications
(27 citation statements)
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“…Based on this evidence, we cannot rule out that more than one neuronal type was stimulated in the present work, which may explain the substantive increase in NREM sleep time observed in two of the mice contrasting with the rest of the cohort in the sleep study. Thus, it is becoming evident that further studies will require a more nuanced approach, identifying and manipulating these neurons based on specific projection sites or neurochemical markers (Chung et al, 2017;Harding et al, 2018;Reitz et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…Based on this evidence, we cannot rule out that more than one neuronal type was stimulated in the present work, which may explain the substantive increase in NREM sleep time observed in two of the mice contrasting with the rest of the cohort in the sleep study. Thus, it is becoming evident that further studies will require a more nuanced approach, identifying and manipulating these neurons based on specific projection sites or neurochemical markers (Chung et al, 2017;Harding et al, 2018;Reitz et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…Whereas optogenetic activation of CCK-and CRH-positive neurons increased both NREM and REM sleep (Chung et al, 2017), optogenetic activation of Tac1-positive neurons increased only NREM sleep and not REM sleep (Chung et al, 2017). However, chemogenetic activation of Tac1-positive POA neurons increased wakefulness (Reitz et al, 2020).…”
Section: Diverse Poa Neurons Regulate Sleep/wakefulnessmentioning
confidence: 94%
“…Mice without galaninergic neurons due to a gene-editing virus in the VLPO showed impairment of sleep homeostasis during sleep recovery after sleep deprivation and a decrease in the delta wave power of EEG; this was incapable of inducing delta waves following dexmedetomidine administration, indicating that sleep and dexmedetomidine require the involvement of POA [ 14 ]. Furthermore, activation of POA tachykinin 1 (Tac-1) neurons promoted and stabilized wake from NREM and REM sleep and showed reduced sensitivity to isoflurane anesthesia and an easier emergence from isoflurane and sevoflurane anesthesia [ 15 ]. Although this result was contrary to the previous finding that POA Tac1 neurons promoted NREM sleep [ 16 ], it provided more evidence for POA neurons mediating both sleep and anesthesia.…”
Section: Preoptic Areamentioning
confidence: 99%