Activation of the anti-tumor effector cells by Radix bupleuri

Kok, L.D.S.; Wong, Chun Kwok; Leung, Kwok Nam; Tsang, Sy; Fung, Kwok‐Pui; Choy, Y.M.

doi:10.1016/0162-3109(95)00010-q

Cited by 27 publications

(9 citation statements)

References 24 publications

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“…Bupleuri Radix, a drug used in traditional oriental medicine, has been used in the treatment of a variety of diseases, including chronic hepatic inflammation, viral hepatitis, menstrual disorders and depression. One of the most active Bupleuri Radix components, saikosaponin, has anticancer effects in vitro and in vivo [24,25]. Based on our results, Bupleuri Radix has different effects on the cytotoxicity of 5-fluorouracil in HepG2 cells and normal human lymphocytes.…”

Section: Discussionmentioning

confidence: 94%

Effect of Bupleuri Radix Extracts on the Toxicity of 5‐Fluorouracil in HepG2 Hepatoma Cells and Normal Human Lymphocytes

Kang

Lee

Kim

et al. 2008

Basic Clin Pharma Tox

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Section: Discussionmentioning

confidence: 94%

Effect of Bupleuri Radix Extracts on the Toxicity of 5‐Fluorouracil in HepG2 Hepatoma Cells and Normal Human Lymphocytes

Kang

Lee

Kim

et al. 2008

Basic Clin Pharma Tox

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“…Many researchers believe that herbal compound does not have direct cytotoxic effect (Kok et al, 1995). The anticancer properties of these herbs are often thought to be related to the activation of macrophages, which through the release of cytokines accomplish the cytotoxic effect (Haranaka et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

The inhibitory effect of a herbal formula comprising ginseng and carthamus tinctorius on breast cancer

2004

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“…The method of Kok et al (1995) was followed. Briefly, the purified NK cells (5 × 10 6 ) were cultured at 37 • C for 18 hr with medium alone or in medium containing human IL-2 (1000 U/ml; Sigma) and different concentrations of plant extracts (i.e., 0.5, For personal use only.…”

Section: Cytotoxic Activity Of Nk Cells In Vitromentioning

confidence: 99%

Enhancement of Natural Killer Cell ActivityIn VitroAgainst Human Tumor Cells by Some Plants From Jordan

Shabsoug

Khalil

Abuharfeil

2008

Journal of Immunotoxicology

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The effect of different concentrations (0, 0.01, 0.1, and 0.5 mg/ml) of plant aqueous extracts on the anti-tumor activity of natural killer (NK) cells isolated from human blood was examined. Plant extracts induced significant enhancement of (26.6-67.7%) of NK cell activity against K562 tumor cells. This increase in NK cell cytotoxicity was found to be due to the enhancement of NK cell production of interferon-gamma (87-337%), and on tumor necrosis factor-alpha (60-200%). Furthermore, the release of both granzyme A and N-acetyl-beta-D-glucosaminidase was increased significantly when compared with controls. Activation of granzyme A and N-acetyl-beta-D-glucosaminidase was clearly observed ranging from 24.2-106.4% to 26.8-110.7%, respectively. Lastly, in the absence of IL-2, plant extracts caused a significant increase in NK-cell-induced cytotoxicity (256%) against K562 tumor cells, and in the presence of IL-2 stimulated cells plant extracts caused an increase in NK cell-cytotoxicity (112%).

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Activation of the anti-tumor effector cells by Radix bupleuri

Cited by 27 publications

References 24 publications

Effect of Bupleuri Radix Extracts on the Toxicity of 5‐Fluorouracil in HepG2 Hepatoma Cells and Normal Human Lymphocytes

Effect of Bupleuri Radix Extracts on the Toxicity of 5‐Fluorouracil in HepG2 Hepatoma Cells and Normal Human Lymphocytes

The inhibitory effect of a herbal formula comprising ginseng and carthamus tinctorius on breast cancer

Enhancement of Natural Killer Cell ActivityIn VitroAgainst Human Tumor Cells by Some Plants From Jordan

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