2012
DOI: 10.1016/j.biocel.2011.10.022
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Activation of VEGFR-2 signaling in response to moderate dose of ultraviolet B promotes survival of normal human keratinocytes

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Cited by 26 publications
(39 citation statements)
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“…[27] Moreover, the fact that keratinocytes express functional VEGFRs implies that VEGF can directly influence these cells during wound repair. [28] Better re-epithelialization with PLGA-VEGF NP was also attributed to the effect of VEGF on keratinocyte and fibroblast migration that was evident from the in vitro wound healing assay. VEGF is a strong chemo attractant for keratinocytes and fibroblasts that promotes their migration and recruitment into the active mitotic region of wounds.…”
Section: Discussionmentioning
confidence: 90%
“…[27] Moreover, the fact that keratinocytes express functional VEGFRs implies that VEGF can directly influence these cells during wound repair. [28] Better re-epithelialization with PLGA-VEGF NP was also attributed to the effect of VEGF on keratinocyte and fibroblast migration that was evident from the in vitro wound healing assay. VEGF is a strong chemo attractant for keratinocytes and fibroblasts that promotes their migration and recruitment into the active mitotic region of wounds.…”
Section: Discussionmentioning
confidence: 90%
“…Studies in other systems have suggested possible roles for VEGF in the regulation of keratinocyte proliferation, migration, and survival. 62,66,82,83,86 Although the contribution of direct effects of VEGF on keratinocytes has yet to be examined specifically in wound-healing models, together these studies imply that VEGF could directly contribute to the repair of the epidermal barrier during wound healing by stimulating keratinocytes.…”
Section: Direct Effects Of Vegf On Keratinocytesmentioning
confidence: 99%
“…To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound keratinocytes. 66 Furthermore, VEGF has been shown to mediate keratinocyte survival following exposure to ultraviolet light, 83,86 and both VEGFR-1 and NRP-1 have been shown to regulate keratinocyte function in vivo. [81][82][83] Overall, the fact that keratinocytes express functional VEGFRs implies that VEGF can directly influence these cells during wound repair.…”
Section: Direct Effects Of Vegf On Keratinocytesmentioning
confidence: 99%
“…These findings strongly suggest an angiogenesis-mediated effect of paracrine/exogenous VEGF in HPV8-induced tumor development, because robust levels of VEGFR2 expression could only be detected in the tumor vasculature but not in keratinocytes. Currently, there is some controversy about the expression of VEGFR2 in keratinocytes (33,35,(41)(42)(43), which may be explained by different experimental conditions and/or keratinocyte sources. However, as shown by IHC and in part also gene expression analysis, Nrp1 and VEGFR1 were not only expressed in vascular structures, but also in the hyperplastic epidermis of tumor lesions, proposing in addition an angiogenesis-independent, potentially autocrine effect mediated by epidermal VEGF.…”
Section: Discussionmentioning
confidence: 99%