2021
DOI: 10.1016/j.bbr.2021.113292
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Activation of VTA GABA neurons disrupts reward seeking by altering temporal processing

Abstract: The role of ventral tegmental area (VTA) dopamine in reward, cue processing, and interval timing is well characterized. Using a combinatorial viral approach to target activating DREADDs (Designer Receptors Exclusively Activated by Designer Drugs, hM3D) to GABAergic neurons in the VTA of male rats, we previously showed that activation disrupts responding to reward-predictive cues. Here we explored how VTA GABA neurons influence the perception of time in two fixed interval (FI) tasks, one where the reward or int… Show more

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Cited by 8 publications
(2 citation statements)
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“…This is true also for VTA GABA and glutamate neurons. For example, activating VTA GABA neurons either locally within VTA or from distal processes can drive behavioral avoidance, disrupt reward seeking, or modify opioid reinforcement ( Corre et al, 2018 ; Root et al, 2020 ; Shields et al, 2021 ; Soden et al, 2020 ; Tan et al, 2012 ; van Zessen et al, 2012 ; Zhou et al, 2022 ). On the other hand, stimulation of VTA GABA projections to LHb can be rewarding ( Lammel et al, 2015 ; Stamatakis et al, 2013 ).…”
Section: Introductionmentioning
confidence: 99%
“…This is true also for VTA GABA and glutamate neurons. For example, activating VTA GABA neurons either locally within VTA or from distal processes can drive behavioral avoidance, disrupt reward seeking, or modify opioid reinforcement ( Corre et al, 2018 ; Root et al, 2020 ; Shields et al, 2021 ; Soden et al, 2020 ; Tan et al, 2012 ; van Zessen et al, 2012 ; Zhou et al, 2022 ). On the other hand, stimulation of VTA GABA projections to LHb can be rewarding ( Lammel et al, 2015 ; Stamatakis et al, 2013 ).…”
Section: Introductionmentioning
confidence: 99%
“…GABAergic neurons in the VTA have profound inhibitory control of the local DA neurons ( Tan et al, 2012 ; Simmons et al, 2017 ), and they also send projections outside the VTA ( Bouarab et al, 2019 ; Chowdhury et al, 2019 ). Thus, it is not surprising that inhibitory VTA neurons are involved in multiple behavioral processes, such as innate defensive behavior ( Zhou et al, 2019 ), aversive behavior ( Tan et al, 2012 ; Li et al, 2019 ), discouragement to get the reward ( van Zessen et al, 2012 ; Pan et al, 2013 ; Shields et al, 2021 ), and drug abuse ( Nugent et al, 2007 ; Nugent and Kauer, 2008 ; Guan and Ye, 2010 ; Niehaus et al, 2010 ). Recently, we and others found that GABAergic neurons in the VTA are also critically involved in sleep/wakefulness regulation ( Chowdhury et al, 2019 ; Yu et al, 2019 ).…”
Section: Introductionmentioning
confidence: 99%