Active components of intestinal bacteria for abdominal irradiation-induced inhibition of lung metastases

Jibu, Tatsuo; Andō, Kōichi; Matsumoto, Tsuneya; Koike, Sachiko; Kobori, Oichiro; Morioka, Yasuhiko; Kanegasaki, Shiro

doi:10.1007/bf01768581

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…We previously reported an antimetastatic activity of bacterial lipopolysaccharide (LPS), the lipid component of the outer membrane of Gramnegative bacteria, against a weakly immunogenic murine fibrosarcoma, the NFSa tumor [1]. The mechanism underlying the activity is suggested to be non-immunological response of host mice [2].…”

Section: In~oducfionmentioning

confidence: 99%

Significance of platelets in an antimetastatic activity of bacterial lipopolysaccharide

Kimoto

Andō²,

Koike³

et al. 1993

Clin Exp Metast

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Recently we reported an antimetastatic activity of bacterial lipopolysaccharide (LPS) on a NK-cell-resistant murine fibrosarcoma (NFSa). Here we investigate and report the mechanistic significance of platelets in this activity. The number of circulating platelets was reduced to 63% of the control 3 days after an i.v. injection of 1.0 micrograms LPS, and then recovered to the level of control at day 10. Aggregation efficiency of platelets was impaired by LPS. The number of metastatic lung colonies after an i.v. injection of tumor cells was maximally reduced to 2.2% of the control at day 3 and increased in proportion to the recovery of platelet number. Neuraminidase (Ndase), which caused a non-immunological thrombocytopenia, also inhibited lung metastasis when injected prior to an i.v. tumor cell challenge. LPS and Ndase showed an identical pattern against five other syngeneic tumors; these agents inhibited lung metastases of the FSa fibrosarcoma and the SCC VII squamous cell carcinoma but failed to inhibit those of the NR-S1 squamous cell carcinoma, the MMCa#4 mammary adenocarcinoma and the NR-PG parotid gland tumor. All the three cells which were not responsive to any agents possessed a high aggregating activity of platelets while the other three tumors responsive to both agents did not show a detectable level of this activity. Platelet transfusion failed to modify the antimetastatic activity of LPS. These results suggest that platelets play an important role in the antimetastatic activity of LPS, though whether the role is principal or assistant remains to be seen.

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Section: In~oducfionmentioning

confidence: 99%

Significance of platelets in an antimetastatic activity of bacterial lipopolysaccharide

Kimoto

Andō²,

Koike³

et al. 1993

Clin Exp Metast

Self Cite

View full text Add to dashboard Cite

show abstract

“…As the antimetastatic activity was most marked when LPS was injected before, but not after, i.v. tumor cell inoculation, the early stages in the metastatic process such as the circulation in blood and the initial lodgement at capillaries were no doubt critical to the antitumor activity of LPS [2]. NK cells normally circulate in peripheral blood.…”

Section: Introductionmentioning

confidence: 99%

Antimetastatic activity of lipopolysaccharide against a NK-resistant murine fibrosarcoma

Jibu

Koike²,

Andō³

et al. 1993

Clin Exp Metast

Self Cite

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An intravenous injection of bacterial lipopolysaccharide (LPS) into mice exerted prominent antimetastatic activities against a NK-resistant weakly immunogenic NFSa fibrosarcoma. The number of visible metastases in the lung was increased by a pretreatment of anti-asialoGM1 (asGM1) antibody or silica, but pretreatment of asGM1 antibody or silica scarcely affected the antimetastatic activities of LPS. The pulmonary retention of radiolabeled tumor cells showed that LPS accelerated the detachment of the tumor cells from the lung, and that this acceleration was not suppressed by anti-asGM1 antibody. Sialic acids of lung endothelial cell surface, essential components of various receptors, was diminished by the i.v. injection of LPS. These results suggested that the antimetastatic effect of LPS against NK-resistant NFSa cells was partly the result of modulations of lung endothelial cell surface.

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The potential roles of bacteria to improve radiation treatment outcome

et al. 2017

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Many combined therapies have been proposed to enhance radiotherapy outcome, but they have several limitations. As a new feasible strategy, combination of radiotherapy with bacteria showed a significant positive impact on the tumor treatment and metastasis inhibition. Although probiotic bacteria and radiotherapy alone can be effective in the treatment of different cancers, the combination of these two therapies seems to enhance therapeutic outcome and is cost-effective. Bacterial cells can act as therapeutic/gene/drug delivery vehicles as well as theranostic agents. In this communication, we reviewed current evidences, studies, suggestions, and future-based directions on combination of radiotherapy and bacteria. In another sections, an overview on tumor hypoxia, bacteria in cancer therapy, and combination of radiotherapy and bacteria is presented. A brief overview on trials and animal studies which used bacteria to protect normal tissues against radiotherapy-induced complications is also included.

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Active components of intestinal bacteria for abdominal irradiation-induced inhibition of lung metastases

Cited by 5 publications

References 27 publications

Significance of platelets in an antimetastatic activity of bacterial lipopolysaccharide

Significance of platelets in an antimetastatic activity of bacterial lipopolysaccharide

Antimetastatic activity of lipopolysaccharide against a NK-resistant murine fibrosarcoma

The potential roles of bacteria to improve radiation treatment outcome

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