In the last decade, there has been a great interest in applying Demand Side Management (DSM) actions in electric power systems as an alternative to constructing and operating new capacity generation units. Also, DSM allows customers to make decisions that affect their energy consumption, which reduces peak-hour energy providers' demand and reshapes the load profile. This paper proposes a methodology for applying load reduction results from DSM techniques to electric power networks. This methodology uses sensitivity analysis to select the buses on which the load reduction will be performed. Furthermore, changes in hourly system loading are considered, and the impacts of these variations on the system's performance are analyzed. Also, the Monte Carlo Simulation (MCS) methodology has been utilized to consider the load uncertainties. The DSM has been effectively validated on two power distribution networks. The first is the IEEE 33 standard system, while the second is a practical distribution network, which is Shebin El Kom feeder-Menoufia Governorate South Delta Electricity Company. Different indicators are used to assess the enhancement of the network's performance. Simulation results concluded that applying DSM techniques reduced the power taken from the substation, reduced the active power losses, and improved the minimum voltage with the daily loading variation as well as at peak loading.