Active Immunization Against Poliomyelitis

Brodie, Maurice; Park, William H.

doi:10.1001/jama.1935.02760400005002

Cited by 25 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They then injected the experimental poliovirus vaccine into about 75 children. 67 Serum antibodies to the virus were formed. No untoward effects occurred.…”

Section: Research At the Rockefeller Institute In New Yorkmentioning

confidence: 99%

Karl Otto Landsteiner (1868–1943). Physician–biochemist–immunologist

Goldman

Schmalstieg

2016

J Med Biogr

View full text Add to dashboard Cite

Karl Landsteiner applied the sciences of biochemistry, pathology, microbiology, and immunology in medical research to great success during the first half of the 20th century. Although he is principally known for elucidating the major blood group antigens A and B and their isoantibodies for which he was awarded the Nobel Prize in Physiology or Medicine, Landsteiner made many other important medical discoveries. In that respect, he ascertained that paralytic poliomyelitis was due to a virus, the pancreas was damaged in cystic fibrosis, simple chemicals called haptens were able to combine with antibodies, and the Rh antigen that was later found to be the principal cause of hemolytic anemia of the newborn was found in most humans. Moreover, Landsteiner's book "The Specificity of Serological Reactions" was a precursor to the molecular revolution in immunology that occurred after Second World War. Finally, he was one of the leaders of the American Association of Immunology and of the Journal of Immunology.

show abstract

“…They then injected the experimental poliovirus vaccine into about 75 children. 67 Serum antibodies to the virus were formed. No untoward effects occurred.…”

Section: Research At the Rockefeller Institute In New Yorkmentioning

confidence: 99%

Karl Otto Landsteiner (1868–1943). Physician–biochemist–immunologist

Goldman

Schmalstieg

2016

J Med Biogr

View full text Add to dashboard Cite

show abstract

“…During the early 1930s, studies were undertaken to vaccinate humans with infected monkey spinal cord suspensions inactivated with formalin or sodium ricinoleate (Kolmer et al, 1935;Brodie and Park, 1936). Both killed and live virus vaccine candidates were developed as early as 1910, although at that time information on the existence of three distinct poliovirus types was not available.…”

Section: Yersinia Pestismentioning

confidence: 99%

Historical Aspects of Mucosal Immunology

Městecký

2015

Mucosal Immunology

View full text Add to dashboard Cite

“…Demonstration that serum from convalescents can protect from poliomyelitis (Kramer et al 1932) and that monkeys can be immunized by inactivated virus (Brodie 1934) led to the attempt to actively immunize humans (Brodie and Park 1935). Demonstration that serum from convalescents can protect from poliomyelitis (Kramer et al 1932) and that monkeys can be immunized by inactivated virus (Brodie 1934) led to the attempt to actively immunize humans (Brodie and Park 1935).…”

Section: Natural History Of Poliomyelitis and Milestones In Discoverymentioning

confidence: 99%