Active inflammatory biomarkers in oral lichen planus

Santarelli, Andrea; Mascitti, Marco; Rubini, Corrado; Bambini, Fabrizio; Zizzi, Antonio; Offidani, Annamaria; Ganzetti, Giulia; Laino, Luigi; Cicciù, Marco; Muzio, Lorenzo Lo

doi:10.1177/0394632015592101

Cited by 17 publications

(12 citation statements)

References 34 publications

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“…As saliva reflects the current physiological and pathological body conditions [43,44], alterations in its biochemical composition could be interpreted as an indirect expression of the well-known metabolic impairments occurring in EDs. Moreover, the oxidative stress could play a role in the development and maintenance of AN or could be one of its downstream effects [45,46,47].…”

Section: Discussionmentioning

confidence: 99%

Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Mascitti¹,

Coccia²,

Vignini³

et al. 2019

Dentistry Journal

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The aim of this study was to compare the oral health status and salivary antioxidant system between patients diagnosed with anorexia nervosa (AN) and healthy controls. A total of 25 female AN patients and 25 matched healthy controls were enrolled. Clinical parameters and saliva samples were collected for each patient. Two questionnaires to investigate oral health and hygiene were administered. Superoxide Dismutase (SOD) activity and High Reactive Oxygen Species (hROS) were evaluated. Salivary concentration of SOD was significantly higher in subjects with AN compared with control group (1.010 ± 0.462 vs. 0.579 ± 0.296 U/mL; p = 0.0003). No significant differences between groups were identified for hROS (233.72 ± 88.27 vs. 199.49 ± 74.72; p = 0.15). Data from questionnaires indicated that, although most of the patients recognized the oral hygiene importance in maintaining a good oral health, more than half of them had poor oral hygiene. Altered biochemical composition of saliva in patients with AN could be interpreted as an effective defence mechanism against oxidative stress. Moreover, despite the discrepancy between clinical findings and perception of the oral health in AN population arose, the quality of life of these patients appears not to be significantly affected by their dental condition.

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Section: Discussionmentioning

confidence: 99%

Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Mascitti¹,

Coccia²,

Vignini³

et al. 2019

Dentistry Journal

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“…Santarelli et al reported that CD44 and osteopontin expression in epithelium of OLP patients were significantly higher than the control group and they concluded that these markers could play a role in the pathogenesis of OLP (19). Siponen et al also demonstrated a higher expression of hyaluronan, CD44, HASI-3, and HYALI-2 in the epithelium of OLP patients compared to the control group (20).…”

Section: Discussionmentioning

confidence: 98%

CD44 Expression in Dysplastic and Non-Dysplastic Oral Lichen Planus

et al. 2020

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Background: Oral lichen planus (OLP) is a relatively common chronic inflammatory autoimmune disease. OLP is more resistant than skin form and malignant transformation into oral squamous cell carcinoma (OSCC) has been reported in this lesion. Since SCC often originates from dysplastic lesions, evaluation of cancer stem cell (CSC) markers in dysplastic and premalignant lesions such as OLP seems to be necessary. Furthermore, chronic inflammation may induce some epithelial malignancies. CD44 as a CSC marker is expressed on epithelial cells and contributes to cell migration and tumor progression. Also, this cell adhesion molecule is expressed on leukocytes involved in various inflammatory diseases. Methods: Thirty samples of erosive/atrophic OLP (15 samples of dysplastic OLP and 15 samples of non-dysplastic OLP), and 10 normal mucosa specimens of the oral cavity were examined using immunohistochemistry. Results: The greatest total score for epithelial immunoreactivity was found in dysplastic OLP, followed by non-dysplastic OLP and normal mucosa with significant differences (P < 0.001). For sub-epithelial lymphocytes immunoreactivity, the greatest total score was reported in dysplastic OLP, followed by non-dysplastic OLP. Conclusions: Significant higher expression of CD44 as a CSC marker in the epithelium of dysplastic OLP may show the role of this marker in malignant transformation and carcinogenesis process of this premalignant lesion. Higher immunoreactivity in subepithelial lymphocytes of dysplastic type indicates a probable role of chronic inflammation in the malignant potential of OLP.

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“…There is also an increased risk for dental caries, teeth erosion, periodontal disease, tongue papillary atrophy, pain, and oral ulcers. Furthermore, patients can report hoarseness, dysphagia, oropharyngeal infections, feeding/swallowing impairment, intolerance to acidic or spicy food, dysgeusia, and gastric acid reflux due to inadequate salivary buffering action (Antoniades et al, 2006; Herrera-Calvo et al, 2011; Santarelli et al, 2015).…”

Section: Glandular Parenchyma Anomaliesmentioning

confidence: 99%

Unusual Conditions Impairing Saliva Secretion: Developmental Anomalies of Salivary Glands

et al. 2019

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Salivary glands (SG) arise from ectodermal tissue between 6 and 12th weeks of intrauterine life through finely regulated epithelial-mesenchymal interactions. For this reason, different types of structural congenital anomalies, ranging from asymptomatic anatomical variants to alterations associated with syndromic conditions, have been described. Notable glandular parenchyma anomalies are the SG aplasia and the ectopic SG tissue. Major SG aplasia is a developmental anomaly, leading to variable degrees of xerostomia, and oral dryness. Ectopic SG tissue can occur as accessory gland tissue, salivary tissue associated with branchial cleft anomalies, or true heterotopic SG tissue. Among salivary ducts anomalies, congenital atresia is a rare developmental anomaly due to duct canalization failure in oral cavity, lead to salivary retention posterior to the imperforate orifice. Accessory ducts originate from the invagination of the developing duct in two places or from the premature ventral branching of the main duct. Heterotopic ducts may arise from glandular bud positioned in an anomalous site lateral to the stomodeum or from the failure of the intraoral groove development, hindering their proximal canalization. These anomalies require multidisciplinary approach to diagnosis and treatment. While ectopic or accessory SG tissue/ducts often do not require any treatment, patients with SG aplasia could benefit from strategies for restoring SG function. This article attempts to review the literature on SG parenchyma and ducts anomalies in head and neck region providing clinicians with a comprehensive range of clinical phenotypes and possible future applications of bioengineered therapies for next-generation of regenerative medicine.

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Active inflammatory biomarkers in oral lichen planus

Cited by 17 publications

References 34 publications

Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

CD44 Expression in Dysplastic and Non-Dysplastic Oral Lichen Planus

Unusual Conditions Impairing Saliva Secretion: Developmental Anomalies of Salivary Glands

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