Active Metabolites from Endolichenic Fungus <i>Talaromyces</i> sp.

Yuan, Weiping; Teng, Mengting; Sun, Shanshan; Ma, Lin; Yuan, Bo; Ren, Qiang; Zhang, Peng

doi:10.1002/cbdv.201800371

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…In the case of the genus Phoma , there is only one report of antioxidant compounds, for example, bromochlorogentisylquinones A and B, chlorogentisyl alcohol, and gentisyl alcohol from P. herbarum [43]. Some antioxidants have been reported from the genus Talaromyces , for example, 8-hydroxyconiothyrinone B, 8,11-dihydroxyconiothyrinone B, 4R,8-dihydroxyconiothyrinone B, 4S,8-dihydroxyconiothyrinone B, and 4S,8-dihydroxy-10-O-methyldendryol E from T. islandicus [44]; pentalsamonin from T. purpureogenus [45]; N-(4-hydroxy-2-methoxyphenyl) acetamide from T. funiculosus [46]; and 6-methylbiphenyl-3,3′,4,5′-tetraol and desmethylaltenusin [47].…”

Section: Resultsmentioning

confidence: 99%

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

et al. 2019

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Intertidal zones are unique environments that are known to be ecological hot spots. In this study, sediments were collected from mudflats and decommissioned salterns on three islands in the Yellow Sea of South Korea. The diversity analysis targeted both isolates and unculturable fungi via Illumina sequencing, and the natural recovery of the abandoned salterns was assessed. The phylogeny and bioactivities of the fungal isolates were investigated. The community analysis showed that the abandoned saltern in Yongyudo has not recovered to a mudflat, while the other salterns have almost recovered. The results suggested that a period of more than 35 years may be required to return abandoned salterns to mudflats via natural restoration. Gigasporales sp. and Umbelopsis sp. were selected as the indicators of mudflats. Among the 53 isolates, 18 appeared to be candidate novel species, and 28 exhibited bioactivity. Phoma sp., Cladosporium sphaerospermum, Penicillium sp. and Pseudeurotium bakeri, and Aspergillus urmiensis showed antioxidant, tyrosinase inhibition, antifungal, and quorum-sensing inhibition activities, respectively, which has not been reported previously. This study provides reliable fungal diversity information for mudflats and abandoned salterns and shows that they are highly valuable for bioprospecting not only for novel microorganisms but also for novel bioactive compounds.

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Section: Resultsmentioning

confidence: 99%

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

et al. 2019

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“…The cytotoxicities against HBE, THLE, and MDA-MB-231 of compound 252 were evaluated by MTT method. 252 exhibited selective cytotoxicities against MDA-MB-231 with IC 50 of 24.6 ±1.3 µg/mL [82].…”

Section: Cytotoxic Activity or Anticancermentioning

confidence: 99%

“…(strain no. MH551540) associated with Xanthoparmelia angustiphylla afforded a new 3methoxy-4,8-bihydroxymethyl-6-methyl-2,4,6-3en-δ-lactone, talaromycin A 252 (Figure 9) [82]. Introducing an alien carbamoyltransferase (asm21) gene into the Streptomyces sp.…”

Section: Lactonesmentioning

confidence: 99%

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Zheng

Zhang

et al. 2021

IJMS

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Secondary metabolites isolated from plant endophytic fungi have been getting more and more attention. Some secondary metabolites exhibit high biological activities, hence, they have potential to be used for promising lead compounds in drug discovery. In this review, a total of 134 journal articles (from 2017 to 2019) were reviewed and the chemical structures of 449 new metabolites, including polyketides, terpenoids, steroids and so on, were summarized. Besides, various biological activities and structure-activity relationship of some compounds were aslo described.

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“…Talaromycin A (52) and clearanol A (53) were isolated from the endophytic fungus Talaromyces sp. MH551540 associated with Xanthoparmelia angustiphylla in 2018 (Yuan et al, 2018). Compound 52 and 53 had selective cytotoxicity against MDA-MB-231 cells.…”

Section: Studies On the Chemical Constituents And Activity Of Talarom...mentioning

confidence: 99%

Research advances in the structures and biological activities of secondary metabolites from Talaromyces

et al. 2022

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The genus Talaromyces belongs to the phylum Ascomycota of the kingdom Fungi. Studies have shown that Talaromyces species yield many kinds of secondary metabolites, including esters, terpenes, steroids, alkaloids, polyketides, and anthraquinones, some of which have biological activities such as anti-inflammatory, bacteriostatic, and antitumor activities. The chemical constituents of fungi belonging to the genus Talaromyces that have been studied by researchers over the past several years, as well as their biological activities, are reviewed here to provide a reference for the development of high-value natural products and innovative uses of these resources.

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Active Metabolites from Endolichenic Fungus Talaromyces sp.

Cited by 13 publications

References 19 publications

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Research advances in the structures and biological activities of secondary metabolites from Talaromyces

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