Actividad sérica de la acetilhidrolasa del factor activador de plaquetas en pacientes afrodescendientes y mestizos con dengue, Colombia

Abstract

599Acetilhidrolasa del factor activador de plaquetas, grupos étnicos y dengue ARTÍCULO ORIGINAL Actividad sérica de la acetilhidrolasa del factor activador de plaquetas en pacientes afrodescendientes y mestizos con dengue, Colombia Palabras clave: 1-alquil-2-acetil-glicerofosfocolina esterasa, dengue, grupos étnicos, Colombia. Serum platelet-activating factor acetylhydrolase activity in dengue patients of African or mestizo descendencyIntroduction: Severe dengue infection is characterized by enhanced vascular permeability produced by cytokines and biochemical mediators. One of these mediators is the platelet-activating factor. Degradation of platelet-activating factor is accomplished by its specific acetylhydrolase. Down or up regulation of this enzyme has been linked to several diseases. However, the role of this enzyme in dengue infection is unknown, a well as whether differential activity occurs by ethnic group. Objective: The activity of the platelet-activating factor-acetylhydrolase was compared in patients infected with dengue virus in two ethnic groups. Material and methods: A descriptive, prospective and longitudinal study was made in two states of Colombia (Antioquia and Chocó). Serum samples were taken from 43 mestizo patients and 33 patients of African descent, each taken during five consecutive days of the acute dengue phase. A second serum sample was taken during the convalescent phase. Results:The mestizo patients showed higher frequency of dengue hemorrhagic fever than the patients of African descent (23.3% vs. 12.1%, p=0.25). The serum activity of the platelet-activating factor acetylhydrolase was higher in African descendents than in mestizos (0. Contribución de los autores:Berta Nelly Restrepo: idea de la investigación, escritura del proyecto, análisis de la información y escritura del manuscrito. Margarita Arboleda: captación de pacientes en la región de Urabá y revisión del artículo. Ruth Ramírez: elaboración de la bases de datos y procesamiento de las muestras de laboratorio. Gonzalo Álvarez: análisis de la información y escritura del manuscrito. Biomédica 2011;31:599-607 600Restrepo BN, Arboleda M, Ramírez R, Álvarez GConclusion. An increased production of platelet-activating factor-acetylhydrolase occurs in the serum of dengue-infected African descendants. However, a study of the frequencies of polymorphisms for this enzyme will permit more conclusive support for these observations.

Liporotein-associated phospholipase-A2 can be a diagnostic marker inthe early stage diagnosis of acute mesenteric ischemia

“…Lp-LPA 2 is used and studied in many disorders such as oxidative stress, atherosclerosis, coronary artery disease, cardiac insufficiency, Alzheimer disease, transient ischemic attack (8), cerebrovascular disorder (9), allergic lung diseases, HIV-positive patients, intracranial hemorrhage in preterm infants (10), hypertensive patients, subarachnoid hemorrhage, nonsmall cell lung cancer (11), patients with African dengue (12), hemodialysis patients, diabetes mellitus, multiple sclerosis with immune response (13), polycystic ovary syndrome (14), systemic sclerosis (15), nonalcoholic fatty liver disease, high-grade carotid stenosis with unstable plaque, and metabolic syndrome.…”

Changes in the Immunology of Breast Milk From Obese or Overweight Women: a Brief Review

“…Platelet-activating factor acetylhydrolase activates target cells such as platelets and neutrophils by binding to specific G protein-coupled cell surface receptors. It is involved in normal physiological processes such as inflammatory response and hemostasis [ 18 ]. With these data in mind, we can analyze the different components of breast milk that are related to immune function.…”