Actividades proteinasa y fosfolipasa de aislamientos de Candida albicans provenientes de secreciones vaginales con distintos valores de pH

Ombrella, Adriana María; Racca, Liliana; Ramos, Laura

doi:10.1016/s1130-1406(08)70004-4

Cited by 18 publications

(19 citation statements)

References 29 publications

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“…Some studies have evaluated the protease activity of Candida species; however, in those researches, the strains were obtained from humans with candidiasis (Kantarcioglu & Yucel, 2002; Mohan & Ballal, 2008; Ombrella et al , 2008). In our study, the production of protease by Candida spp.…”

Section: Discussionmentioning

confidence: 99%

Yeasts from Macrobrachium amazonicum: a focus on antifungal susceptibility and virulence factors of Candida spp.

Brilhante

Paiva

Sampaio

et al. 2011

FEMS Microbiology Ecology

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In the present study, it was sought to compare yeast microbiota of wild and captive Macrobrachium amazonicum and evaluate the antifungal susceptibility and production of virulence factors by the recovered isolates of Candida spp. Additionally, cultivation water was monitored for the presence of fungi. Overall, 26 yeast isolates belonging to three genera and seven species were obtained, out of which 24 were Candida spp., with Candida famata as the most prevalent species for both wild and captive prawns. From cultivation water, 28 isolates of filamentous fungi were obtained, with Penicillium spp., Cladosporium spp. and Aspergillus spp. as the most frequent genera. Eight out of 24 Candida spp. isolates were resistant to azole derivatives, out of which four were recovered from wild-harvested prawns. As for production of virulence factors, three (12.5%) and eight (33.3%) isolates presented phospholipase and protease activity, respectively. This is the first comparative study between wild and captive prawns and the first report on yeast microbiota of M. amazonicum. The most relevant finding was the high percentage of resistant Candida spp., including from wild individuals, which suggests the occurrence of an environmental imbalance in the area where these prawns were captured.

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Section: Discussionmentioning

confidence: 99%

Yeasts from Macrobrachium amazonicum: a focus on antifungal susceptibility and virulence factors of Candida spp.

Brilhante

Paiva

Sampaio

et al. 2011

FEMS Microbiology Ecology

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“…Phospholipases act by invading host cells, causing tissue damage, rupturing the epithelial cell membranes, and allowing hyphae to penetrate the cytoplasm. Proteinase production increases the ability of certain organisms to colonize and penetrate host tissue, deceive the host immune system, and disrupt a signifi cant number of proteins important for immunity such as immunoglobulins, complement proteins, and cytokines 5,[7][8][9] . Yeast can be induced to produce GTs, which develop into mycelia.…”

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confidence: 99%

Determination of germ tube, phospholipase, and proteinase production by bloodstream isolates of Candida albicans

Mattei

Alves

Severo³

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Candida albicans is a commensal and opportunistic agent that causes infection in immunocompromised individuals. Several attributes contribute to the virulence and pathogenicity of this yeast, including the production of germ tubes (GTs) and extracellular hydrolytic enzymes, particularly phospholipase and proteinase. This study aimed to investigate GT production and phospholipase and proteinase activities in bloodstream isolates of C. albicans. Methods: One hundred fi fty-three C. albicans isolates were obtained from blood samples and analyzed for GT, phospholipase, and proteinase production. The assays were performed in duplicate in egg yolk medium containing bovine serum albumin and human serum. Results: Detectable amounts of proteinase were produced by 97% of the isolates, and 78% of the isolates produced phospholipase. GTs were produced by 95% of the isolates. A majority of the isolates exhibited low levels of phospholipase production and high levels of proteinase production. Conclusions: Bloodstream isolates of C. albicans produce virulence factors such as GT and hydrolytic enzymes that enable them to cause infection under favorable conditions.

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“…Esta expressão é afetada por fatores nutricionais, condições do ambiente (temperatura e pH) e fase de crescimento da levedura. Fosfolipídios presentes na membrana das células humanas e animais são os substratos (47) .…”

Section: Proteinases E Fosfolipasesunclassified

Fisiopatogenia, epidemiologia e diagnóstico laboratorial da candidemia

Giolo¹,

Svidzinski²

2010

J. Bras. Patol. Med. Lab.

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Candidemia é a infecção da corrente sanguínea causada por leveduras do gênero Candida. As espécies mais comumente isoladas em amostras de sangue venoso de pacientes hospitalizados são C. albicans, C. tropicalis, C. parapsilosis, C. glabrata e C. krusei. A finalidade desse estudo é fornecer uma revisão sobre candidemia, mostrando aspectos importantes sobre etioepidemiologia, relação fungo/hospedeiro e diagnóstico laboratorial desta infecção sistêmica emergente. Durante o processo de estabelecimento da candidemia, a levedura participa ativamente, expressando diversos fatores de virulência, o que acaba por favorecer a patogênese da candidemia. Entre esses fatores, destacam-se produção de enzimas extracelulares, dimorfismo, síntese de hemolisinas, capacidade de adesão e formação de biofilme. Nos pacientes acometidos, a intervenção medicamentosa deve ser precoce para minimizar os riscos de complicações e de resistência microbiana, portanto um diagnóstico laboratorial eficiente se faz necessário. O estudo e o conhecimento desses fatores, associados à genotipagem, podem contribuir de maneira decisiva para a descoberta de novos fármacos que possam atuar como profiláticos e/ou terapêuticos em pacientes com candidemia ou em risco de desenvolvê-la.

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Actividades proteinasa y fosfolipasa de aislamientos de Candida albicans provenientes de secreciones vaginales con distintos valores de pH

Cited by 18 publications

References 29 publications

Yeasts from Macrobrachium amazonicum: a focus on antifungal susceptibility and virulence factors of Candida spp.

Yeasts from Macrobrachium amazonicum: a focus on antifungal susceptibility and virulence factors of Candida spp.

Determination of germ tube, phospholipase, and proteinase production by bloodstream isolates of Candida albicans

Fisiopatogenia, epidemiologia e diagnóstico laboratorial da candidemia

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