Activités anti-inflammatoire et analgésique de l’extrait éthanolique de Fumaria capreolata

Bribi, Noureddine; Belmouhoub, M.; Maiza, Fadila

doi:10.1007/s10298-016-1035-6

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…Cook and Samman, (1996) reported that flavonoids due to their high antioxidant capacity have health-promoting properties and help reduce the risk of diseases. Bribi et al, (2017) and Contreras et al, (2017) in their separate studies observed that alkaloid exert antioxidant and analgesic activities, while Feng et al, (2006) reported anti-inflammatory and anxiolytic activities of plant alkaloids. Albuquerque et al, (2005) reported that tannins are known to heal wounds and inflamed mucous membranes, while Wagner and Elmadfa, (2003) reported that they possesses antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

Gestational administration of aqueous leaf extract of Jatropha tanjorensis alleviated postpartum emotional and cognitive dysfunction in rats (Wistar strain)

Antai,

Ukoh,

Sunday

et al. 2023

NJPS

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This study examines the effect of gestational administration of aqueous leaf extract of Jatropha tanjorensis (JT) on postpartum-like behavioural outcomes to delineate its possibility as a prophylactic, therapeutic agent in the treatment of postpartum symptoms. Inseminated female rats (120-150g) were grouped into two-control and JT group (n=10). Control received 20 ml/kg of distilled water and JT group received 500 mg/kg of JT orally once daily for 21 days in gestation. Non-pregnant rats were excluded from the study. Parameters assessed at postpartum include antidepressant-like (force swim test, FST; tail suspension-test, TST), locomotor (open field test, OFT), anxiolytic-like (elevated plus maze, EPM; light-dark box, LDB), learning and memory (T-maze; novel object recognition task, NORT), social (nest score) and analgesic-like (hot plate test, HPT; tail flick test, TFT) behaviours. JT increased (P<0.05) mobility and latency to immobility durations in FST and TST; open arm entry (P<0.001) and duration (P<0.01) in EPM and light box duration (P<0.05) in LDB; locomotion and exploration, but reduced anxiety-like levels in EPM, LDB and OFT. It increased nest score (P<0.05); mean retraction time (P<0.01) of TFT. JT showed positive score for short and long term memory in NORT and improved percentage alternation in T-maze though not significant compared to control. In conclusion, the aqueous extract has a therapeutic effect that reduces postpartum-like depression and anxiety, and improves locomotor activity. JT can be a preventive and adjuvant therapeutic option for pregnant women

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