Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

Multicharged cyclodextrin supramolecular assemblies

“…In molecular recognition and imaging, the detection step can be accomplished by monitoring changes in luminescence, color, or an electronic signal, [306][307][308][309] and activatable chemical sensors have emerged as an important research topic in organic supramolecular chemistry. Here, CDs modified with positively charged functional groups can serve as excellent supramolecular optical probes for the simple and sensitive detection of a wide variety of analytes that cannot be detected by traditional methods, especially when they occur in extremely complex environments such as biological systems.…”

An Activity‐Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO−) in the Alzheimer's Disease Brain

“…[8] Take peroxynitrite (ONOO À ) as an example, as a combinational product of superoxide and nitric oxide, ONOO À is a renowned reactive species in oxidative stress and more detrimental than other reactive oxygen species (ROS). [9] It's also well-evidenced that ONOO À takes a momentous part in the pathogenesis of AD via provoking neurotoxicity and neuroinflammation. [10] But, to date, no ONOO À fluorescent probes can be used in the in vivo brain imaging of AD.…”

Recent Progress of Small‐Molecule Ratiometric Fluorescent Probes for Peroxynitrite in Biological Systems

“…[22][23][24][25][26][27][28][29][30][31][32][33] Therefore, myriad ONOO À -responsive fluorescent probes suitable for fluorescence imaging have been fabricated that have greatly promoted the understanding of ONOO À biology. [34] Most ONOO À -sensitive fluorescent probes display a fluorescence-intensity response at a single wavelength, which is susceptible to technical limitations caused by various interfering factors such as detection environment, probe concentration and photobleaching. However, ratiometric fluorescent probes are able to avoid these intensity-based interferences by built-in correction of two different fluorescence emissions, thus providing more accurate measurement results.…”