Activity-dependent hepatocyte growth factor expression and its role in organogenesis and cancer growth suppression

Siu, David

doi:10.1016/j.mehy.2004.01.031

Cited by 7 publications

(9 citation statements)

References 47 publications

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“…For voltage changes to control complex tissue outcomes, this bioelectrical signal must translate into transcriptional responses. Mechanisms for transduction of voltage gradients and ion flows into second‐messenger cascades and changes of gene expression include: conformational changes in integrin signaling (Olivotto et al, 1996; Arcangeli, 2005), activation of calcium influx through voltage gated calcium channels (Sasaki et al, 2000; Deisseroth et al, 2004; Siu, 2004), regulation of small morphogen movement in and out of cells by voltage‐powered transporters (Fukumoto et al, 2005; Blackiston et al, 2011), and voltage regulation of phosphatase activity (Murata et al, 2005; Okamura and Dixon, 2011). What other mechanisms might be involved?…”

Section: How Does Bioelectricity Interface With Tissue Outcomes?mentioning

confidence: 99%

Transducing Bioelectric Signals into Epigenetic Pathways During Tadpole Tail Regeneration

Tseng

Levin

2012

The Anatomical Record

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One important component of the cell-cell communication that occurs during regenerative patterning is bioelectrical signaling. In particular, the regeneration of the tail in Xenopus laevis tadpoles both requires, and can be initiated at non-regenerative stages by, specific regulation of bioelectrical signaling (alteration in resting membrane potential and a subsequent change in sodium content of blastemal cells). While standing gradients of transmembrane voltage and ion concentration can provide positional guidance and other morphogenetic cues, these biophysical parameters must be transduced into transcriptional responses within cells. A number of mechanisms have been described for linking slow voltage changes to gene expression, but recent data on the importance of epigenetic marks for regeneration suggest a novel hypothesis: that sodium/butyrate transporters link ion flows to influx of small molecules needed to modify chromatin state. Here, we briefly review the data on bioelectricity in tadpole tail regeneration, present a technique for convenient alteration of transmembrane potential in vivo that does not require transgenes, show augmentation of regeneration in vivo by manipulation of voltage, and present new data in the Xenopus tail consistent with the hypothesis that the monocarboxlyate transporter SLC5A8 may link regeneration-relevant epigenetic modification with upstream changes in ion content.

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Section: How Does Bioelectricity Interface With Tissue Outcomes?mentioning

confidence: 99%

Transducing Bioelectric Signals into Epigenetic Pathways During Tadpole Tail Regeneration

Tseng

Levin

2012

The Anatomical Record

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“…While PKA is known to transmit cAMP signal to the downstream transcription factor CREB, PKA‐siRNA inhibited the growth of transformed hepatocytes via the reduction of CREB activity (Figs 4,5). The difference in the inhibition degree between CREB and PKA knockdown may be due to the fact that other factors, such as calmodulin dependent protein kinase, 21,22 iPLA2, 8 p90RSK, 23 Akt and p38, 24 induce the CREB activity in the absence of PKA activity. This possibility was confirmed by the in vitro experiments that iPLA2 knockdown inhibited the CREB activity and hepatocyte replication (Figs 4,5).…”

Section: Discussionmentioning

confidence: 99%

Impaired activities of cyclic adenosine monophosphate‐responsive element binding protein, protein kinase A and calcium‐independent phospholipase A2 are involved in deteriorated regeneration of cirrhotic liver after partial hepatectomy in rats

Zhao

Wakabayashi

Shimoda

et al. 2011

Hepatology Research

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“…It participates in potential pharmacokinetic interactions with anticancer drugs. It is advised that health care professionals and consumers should be aware of the potential for adverse interactions with Panax ginseng, question their patients on their use of them, especially among patients whose disease is not responding to treatments as expected, and urge patients to avoid herbs that could confound their cancer care [2]. Panax ginseng does not appear to enhance physical performance.…”

Section: Side Effectmentioning

confidence: 99%

“…Others have chemopreventive effect. Antineoplastic activities of these natural products are achieved through various mechanisms [2]. Various natural products and their mechanism of action (Table 2) are documented in this paper.…”

Section: Introductionmentioning

confidence: 99%

Natural products and their role in cancer therapy

Siu

2010

Med Oncol

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This paper documented several natural products that have antineoplastic activities. Detailed descriptions of the mechanism of action of these products are given. Side effects of these natural products are also described. Based on these side effect profiles and their benefits, these natural products could be used as adjuvant cancer therapies. Traditional anticancer agents usually have debilitating side effects. These natural products would be of great benefit due to their anticancer activities. Additionally, some of these natural products can work proactively in preventing cancer formation with their chemopreventive properties. Incorporation into diet can be recommended after discussion with physician and other health care professionals.

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Activity-dependent hepatocyte growth factor expression and its role in organogenesis and cancer growth suppression

Cited by 7 publications

References 47 publications

Transducing Bioelectric Signals into Epigenetic Pathways During Tadpole Tail Regeneration

Transducing Bioelectric Signals into Epigenetic Pathways During Tadpole Tail Regeneration

Impaired activities of cyclic adenosine monophosphate‐responsive element binding protein, protein kinase A and calcium‐independent phospholipase A2 are involved in deteriorated regeneration of cirrhotic liver after partial hepatectomy in rats

Natural products and their role in cancer therapy

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