Activity of antioxidant enzymes of the ischemic myocardium

Gutkin, D. V.; Petrovich, Yu. A.

doi:10.1007/bf00837546

Cited by 5 publications

(2 citation statements)

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“…Because these afferent responses were abolished by deferoxamine, these results would suggest that oxygen free radical formation is enhanced throughout the left ventricle in response to coronary occlusion and reperfusion. In support of this notion, other studies have shown that occlusion of the LAD in the rat decreases the activity of antioxidant enzymes and increases free radical formation in both ischemic and nonischemic areas of the heart 11,12…”

Section: Myocardial Ischemia and Reperfusionmentioning

confidence: 80%

“…Several studies have shown that enhanced formation of free radicals does not begin immediately after the onset of ischemia. In the rat heart, an increase in hydroxyl radical production begins about 10 minutes after occlusion of the LAD, and the activity of antioxidant enzymes decreases 20–30 minutes thereafter 11. Nevertheless, 10–15 minutes of coronary occlusion in rats is sufficient to lead to a burst of free radical production during subsequent reperfusion.…”

Section: Myocardial Ischemia and Reperfusionmentioning

confidence: 99%

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Cardiac Vagal Chemosensory Afferents

Schultz

2001

Annals of the New York Academy of Sciences

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Stimulation of cardiac vagal afferent endings evokes reflex hypotension and bradycardia, also known as a Bezold‐Jarisch effect. The physiological importance of this reflex pathway remains uncertain today, but it is increasingly apparent that cardiac vagal afferents can play an important role in modulating cardiovascular control in pathophysiological states, particularly myocardial ischemia. The afferent endings that compose this vagal input are functionally diverse. Ventricular endings exist that are stimulated by wall motion. However, cardiac chemosensitive endings, stimulated by a variety of metabolically active substances known to be produced by the stressed myocardium (e.g., bradykinin, prostaglandins, reactive oxygen species), play a major role in mediating reflex adjustments during myocardial ischemia. Data are presented highlighting the importance of arachidonic acid metabolites and oxygen radicals in activating cardiac vagal endings during myocardial ischemia and reperfusion, and their role in modulating cardiac afferent sensitivity in the disease states of heart failure and insulin‐dependent diabetes.

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Section: Myocardial Ischemia and Reperfusionmentioning

confidence: 80%

Section: Myocardial Ischemia and Reperfusionmentioning

confidence: 99%