Activity of chitosan antifungal denture adhesive against common Candida species and Candida albicans adherence on denture base acrylic resin

Namangkalakul, Worachat; Benjavongkulchai, Sunpatch; Pochana, Teeraphat; Promchai, Alitta; Satitviboon, Wuttika; Howattanapanich, Sukanya; Phuprasong, Rawi; Ungvijanpunya, Nicha; Supakanjanakanti, Danaiya; Chaitrakoonthong, Tatcha; Muangsawat, Sureeporn; Thanyasrisung, Panida; Matangkasombut, Oranart

doi:10.1016/j.prosdent.2019.09.026

Cited by 43 publications

(47 citation statements)

References 40 publications

(66 reference statements)

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“…Poor denture hygiene allows microbial accumulation and may result in mucosal inflammation and infection in denture stomatitis [16,48]. Thus, appropriate denture cleaning protocols should be recommended and the use of non-toxic agent with antifungal activity may provide additional benefit [49]. We did not find statistically significant difference in denture plaque index of Candida carriers and non-carriers (Table 6).…”

Section: Plos Onementioning

confidence: 68%

Hyposalivation, oral health, and Candida colonization in independent dentate elders

2020

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Hyposalivation is an important problem in elders and could interfere with several oral functions and microbial ecology. While the number of independent elders who retain more natural teeth increases worldwide, few studies examined hyposalivation in this population. Thus, this study aims to examine relationships between hyposalivation, oral health conditions and oral Candida colonization in independent dentate elders and evaluate factors associated with salivary flow and Candida carriage. We conducted a cross-sectional study in fifty-three dentate elders (≥65 years old with at least 4 pairs of posterior occlusal contacts) with no, or well-controlled, systemic conditions. Participants were interviewed for medical history, subjective dry mouth symptoms, oral hygiene practices and denture information. Unstimulated and stimulated salivary flow rates, objective dry mouth signs, gingival, tongue-coating, and root-caries indices were recorded. Stimulated saliva was cultured on Sabouraud-dextrose agar for Candida counts. Candida species were identified using chromogenic Candida agar and polymerase chain reaction. Statistical significance level was set at p<0.05. The results showed that hyposalivation was associated with higher gingival and tongue-coating indices (p = 0.003 and 0.015, respectively), but not root-caries index. Hyposalivation was also associated with higher prevalence of oral Candida colonization (p = 0.010; adjusted OR = 4.36, 95% confidence interval = 1.29–14.72). These two indices and Candida load were negatively correlated with unstimulated and stimulated salivary flow rates. Interestingly, non-albicans Candida species were more prevalent in denture wearers (p = 0.017). Hence, hyposalivation is a risk factor for poorer oral health and oral Candida colonization in independent dentate elders. Because of its potential adverse effects on oral and systemic health, hyposalivation should be carefully monitored in elders.

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Section: Plos Onementioning

confidence: 68%

Hyposalivation, oral health, and Candida colonization in independent dentate elders

2020

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“…The relative fungal growth was decreased by CS-salts significantly in all groups compared to the control group (Figure 1). human fibroblast cells [33] and the adhesion to dentures [34]. Furthermore, an in vivo study showed promising results for the use of low-molecular weight (LMW) CS solution for the treatment of DS [35].…”

Section: Antifungal Test: Effect Of Chitosan-salt Solutionsmentioning

confidence: 99%

“…activity of CS nanoparticles as a free solution [29], such as dispersed in tissue conditioner fluid [30], and incorporated into light-cured dental resin [31] as well as for CS incorporated into tissue conditioner [32]. Furthermore, the high molecular weight of CS decreases the hydrophobicity and adhesion of C. albicans to epithelial and human fibroblast cells [33] and the adhesion to dentures [34]. Furthermore, an in vivo study showed promising results for the use of low-molecular weight (LMW) CS solution for the treatment of DS [35].…”

Section: Introductionmentioning

confidence: 99%

Antifungal and Surface Properties of Chitosan-Salts Modified PMMA Denture Base Material

et al. 2020

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Chitosan (CS) and its derivatives show antimicrobial properties. This is of interest in preventing and treating denture stomatitis, which can be caused by fungi. Therefore, the aim of this study was the development of a novel antifungal denture base material by modifying polymethyl methacrylate (PMMA) with CS-salt and characterizing its antifungal and surface properties in vitro. For this purpose, the antifungal effect of chitosan-hydrochloride (CS-HCl) or chitosan-glutamate (CS-G) as solutions in different concentrations was determined. To obtain modified PMMA resin specimens, the CS-salts were added to the PMMA before polymerization. The roughness of these specimens was measured by contact profilometry. For the evaluation of the antifungal properties of the CS-salt modified resins, a C. albicans biofilm assay on the specimens was performed. As solutions, both the CS-G and CS-HCl-salt had an antifungal effect and inhibited C. albicans growth in a dose-dependent manner. In contrast, CS-salt modified PMMA resins showed no significant reduced C. albicans biofilm formation. Furthermore, the addition of CS-salts to PMMA significantly increased the surface roughness of the specimens. This study shows that despite the antifungal effect of CS-salts in solution, a modification of PMMA resin with these CS-salts does not improve the antifungal properties of PMMA denture base material.

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“…499 Many studies have demonstrated the beneficial effects of adding chitosan into dental materials to improve their physical, and mechanical properties. [500][501][502][503][504][505] Perhaps more interestingly, chitosan has been used to enhance periodontal tissue regeneration in many forms. 506 Some examples of periodontal tissue regeneration using chitosan include fabricating electrospun collagen/chitosan membranes and regenerating periodontal tissue in a rat model.…”

Section: Periodontal Tissue Regenerationmentioning

confidence: 99%

Harnessing biomolecules for bioinspired dental biomaterials

et al. 2020

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Activity of chitosan antifungal denture adhesive against common Candida species and Candida albicans adherence on denture base acrylic resin

Cited by 43 publications

References 40 publications

Hyposalivation, oral health, and Candida colonization in independent dentate elders

Hyposalivation, oral health, and Candida colonization in independent dentate elders

Antifungal and Surface Properties of Chitosan-Salts Modified PMMA Denture Base Material

Harnessing biomolecules for bioinspired dental biomaterials

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