Activity of the first line antioxidant defense enzymes in the liver of pubertal rats during stress

Volkova, Yuliya; Sukhova, L. L.; Davydov, Roman; Goloborodko, A.

doi:10.1134/s1990750811040111

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…The endogenous enzymatic antioxidant is composed of two key enzymes: CAT and GPx, which convert hydrogen peroxide into hydrogen oxide (water) and oxygen 40. Therefore, CAT and GPx may play a major role in first-line antioxidant defense against the toxic effects of ROS and can be used as oxidative stress markers 41…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials

Lakzaei

Khodabandehloo

Hosseini

et al. 2019

Postgraduate Medical Journal

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BackgroundResveratrol is a naturally occurring polyphenol compound mainly found in grapes and red wine. The evidence has suggested that resveratrol has an antioxidant effect. However, the results are inconsistent and inconclusive. Thus, we conducted a systematic review and meta-analysis to evaluate the effect of resveratrol supplementation on markers of oxidative stress.MethodsWe searched PubMed, ISI Web of Science, EMBASE, Scopus and the Cochrane library up to December 2018 to identify randomised controlled trials (RCTs) assessing resveratrol supplementation effects on oxidative markers. Heterogeneity, publication bias, risk of bias and subgroup analysis were analysed. This meta-analysis was conducted in accordance with the guidelines of the Preferred ReportingItems for Systematic Reviews and Meta-Analysis (PRISMA).ResultsMeta-analysis of data from 12 RCTs did not support significant effect of resveratrol supplementation on circulating levels of superoxide dismutase (SOD) (standardized mean difference (SMD) (1.12), (95% CI −0.91 to 3.1), p=0.28), catalase (CAT) (SMD (−0.07), (95% CI −1.4 to 1.3), p=0.92) and glutathione peroxidase (GPx) (SMD (−0.76), (95% CI −2.56 to 1.04), p=0.40). Although, resveratrol supplementation increased significantly circulating total antioxidant capacity (TAC) concentrations (SMD (0.52), (95% CI −0.02 to 1.07), p=0.05). Severe heterogeneity was observed between studies, and no obvious publication bias was observed in included RCTs.ConclusionCollectively, our findings of available RCTs did no show any benefit of resveratrol supplementation on SOD, CAT and GPx except for TAC. Well-designed RCTs are necessary to confirm these results.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials

Lakzaei

Khodabandehloo

Hosseini

et al. 2019

Postgraduate Medical Journal

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“…carbonyls, Schiff bases, pubertal age, oxidative stress, immobilization stress. W e have shown earlier that organism sensitivity to oxidative stress increases in pubertal age [1,2]. This may be one of the reasons of the increase of visceral pathology in teenagers [3].…”

Section: T He Aim Of the Work Is To Find Out Peculiarities In Manifesmentioning

confidence: 99%

Oxidative stress and the enzyme system of aldehyde catabolism in the muscle mitochondria of immobilized pubertal rats

Hamdallah¹,

Davydov²,

Shvets³

2014

Ukr.Biochem.J.

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Age-Specific Peculiarities of Modulation of Blood Aldo-Keto Reductase Isoenzyme Spectrum

Davydov

2015

Bull Exp Biol Med

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The aldo-keto reductase spectrum of the blood was studied at different stages of ontogeny to elucidate the role of reduction pathway in utilization of the carbonyl products of free radical oxidation in modulation of organism sensitivity to the damaging effect of stress during ontogeny. The studies revealed the age-specific changes in aldo-keto reductase spectrum in the blood. An analogy of the aldo-keto reductase spectrum structure in animals of early maturity and in old rats was found. The appearance of age specificity of the aldo-keto reductase spectrum in the blood creates metabolic prerequisites for changes in the efficiency of utilization of carbonyl products of free radical oxidation via their reductive transformation.

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Activity of the first line antioxidant defense enzymes in the liver of pubertal rats during stress

Cited by 6 publications

References 8 publications

Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials

Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials

Oxidative stress and the enzyme system of aldehyde catabolism in the muscle mitochondria of immobilized pubertal rats

Age-Specific Peculiarities of Modulation of Blood Aldo-Keto Reductase Isoenzyme Spectrum

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