Activity profiles of antimutagens: in vitro and in vivo data

Waters, Michael D.; Stack, H.Frank; Jackson, Marcus; Brockman, Herman E.; Flora, Silvio De

doi:10.1016/0027-5107(95)00097-6

Cited by 84 publications

(44 citation statements)

References 86 publications

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“…3a, computer-generated models of the AFB 1 -CHL complex provide evidence for the presence of multiple overlapping ring systems, which is an arrangement common to all π-π complexes [16][17][18]. In our studies, several different orientations were examined for AFB 1 and CHL, and the calculated energies indicated highly favored complexes (−16 to −21 kcal/mol). In the most favored orientation, the 8,9-double bond of AFB 1 was arranged 180° away from the CHL carboxyl groups (Fig.…”

Section: Afb 1 -Chl Complex Formationmentioning

confidence: 80%

“…1c). A straight line relationship was obtained between the 9-month liver tumor incidence and the AFB 1 -DNA adducts levels measured after the last dose of AFB 1 . The overall effect of the CHL treatment was to shift the data points towards the origin with each increase in inhibitor dose, along a line of slope equal to approximately 1% tumor incidence per μmol AFB 1 /mole DNA (see dotted line in Fig.…”

Section: Inhibition Of Afb 1 -Dna Adducts and Hepatocarcinogenesis (Mmentioning

confidence: 99%

“…The antimutagenicity profile for CHL contained only 7 out of a total of 93 data points that were from experiments conducted in vivo. The limited nature of the in vivo data notwithstanding, most of the evidence strongly supported a protective role for CHL [1].…”

Section: Introductionmentioning

confidence: 98%

“…Waters et al [1] recently reviewed an extensive database on the activities of several antimutagens in vitro and in vivo, and summarized the results in the form of detailed 'activity profiles'. Among the various inhibitors reviewed, chlorophyllin (CHL) was identified as almost uniformly protective against a broad range of direct-and indirect-acting mutagens, including aflatoxins, polycyclic aromatic hydrocarbons, heterocyclic amines, alkylating agents and several miscellaneous compounds.…”

Section: Introductionmentioning

confidence: 99%

“…In the time since the review by Waters et al [1] was submitted and published, several new in vivo studies with CHL have been reported. Perhaps most notable among these is the work that showed CHL to be a potent inhibitor of aflatoxin B 1 (AFB 1 )-initiated tumorigenesis in rainbow trout [2].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout

Dashwood

Negishi

Hayatsu

et al. 1998

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

121

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Section: Afb 1 -Chl Complex Formationmentioning

confidence: 80%

Section: Inhibition Of Afb 1 -Dna Adducts and Hepatocarcinogenesis (Mmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout

Dashwood

Negishi

Hayatsu

et al. 1998

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

121

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Inhibition of methotrexate-induced chromosomal damage by vanillin and chlorophyllin in V79 cells

Keshava

Whong

et al. 1997

Teratog. Carcinog. Mutagen.

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Methotrexate (MTX), a chemotherapeutic agent used to treat cancer, produces cytogenetic damage and has a cytostatic effect in a variety of test systems. Several antigenotoxic agents have been studied in various in vitro and in vivo systems. However, data are limited regarding their ability to modulate MTX‐induced genotoxicity. In the present study, vanillin (VA) and chlorophyllin (CHL) were used as antigenotoxic agents to study their ability to minimize the DNA damage caused by MTX. Exponentially growing V79 Chinese hamster lung cells were treated with MTX at five different concentrations (5–100 μg/ml) with S9 activation for 6 h and post‐treated with two concentrations of either VA (50 or 100 μg/ml) or CHL (50 or 100 μg/ml) for 40 h. Cytochalasin B was added for the micronucleus (MN) assay along with antigenotoxic agents to evaluate MN in binucleated cells. Chromosomal aberrations were also evaluated in parallel cultures. Results indicate that MTX alone induced a dose‐dependent decrease in the nuclear division index (NDI) and the mitotic index (MI). A significant increase in percent micronucleated binucleated cells (MNBN) and percent aberrant cells (Abs) was observed. Studies using VA as an antigenotoxic agent showed a decrease in the number of MNBN (26.3–83.1%) and Abs (16.0–87.5%) with the addition of either 50 or 100 μg VA/ml. The addition of CHL also significantly reduced the number of MNBN (53.0–91.5%) at both concentrations tested. Chromosomal aberrations were also significantly reduced (41.0–83.0). These studies indicate that both VA and CHL are capable of effectively minimizing MTX‐induced chromosomal damage. Teratogenesis Carcinog. Mutagen. 17:313–326, 1997/98. © 1998 Wiley‐Liss, Inc.

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Effect of five dietary antimutagens on the genotoxicity of six mutagens in the microscreen prophage-induction assay

Cabrera

2000

Environ. Mol. Mutagen.

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Activity profiles of antimutagens: in vitro and in vivo data

Cited by 84 publications

References 86 publications

Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout

Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout

Inhibition of methotrexate-induced chromosomal damage by vanillin and chlorophyllin in V79 cells

Effect of five dietary antimutagens on the genotoxicity of six mutagens in the microscreen prophage-induction assay

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