Actuation and tracking of a single magnetic particle on a chip

Rinklin, Philipp; Krause, Hans‐Joachim; Wolfrum, Bernhard

doi:10.1063/1.3673909

Cited by 4 publications

(11 citation statements)

References 20 publications

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“…The occasional loss of an individual particle is caused by repulsive particle‐particle interactions inside the cloud. When using a single particle approach, the particle directly follows the simulated position of the peak in the magnetic field and can be transferred with 100% efficiency 16.…”

Section: Resultsmentioning

confidence: 99%

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On‐chip control of magnetic particles

Rinklin

Krause

Wolfrum

2012

Physica Status Solidi (a)

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We describe an on-chip system to control the actuation of micrometer-and nanometer-sized magnetic particles. Orthogonal conducting microwire arrays are used to induce magnetic fields with highly localized peaks and strong local gradients. These fields are then applied in actuation experiments to generate defined particle movement with micrometer precision. We examine different types of current sequences to efficiently move and separate the particle cloud on the chip without the use of external magnets. The final protocol allows efficient and reliable control over the particle cloud's position minimizing the loss of particles during the individual switching steps.Schematic of a microwire chip controlling a cloud of particles (black). The chips are processed on silicon (blue). The microwires consist of Au (yellow) and are insulated with an oxide nitride passivation layer (green transparent).

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Section: Resultsmentioning

confidence: 99%

“…Arrays of conducting microwires have previously shown to be useful tools for the generation of highly localized magnetic fields with strong local gradients 12–16. Here, we present an on‐chip system, based on such arrays for the control of defined clouds of magnetic particles.…”

Section: Introductionmentioning

confidence: 99%

On‐chip control of magnetic particles

Rinklin

Krause

Wolfrum

2012

Physica Status Solidi (a)

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“…The magnetic fields were simulated using analytical expressions for the magnetic field of a wire of rectangular cross-section as described before. 45 Briefly, Biot-Savart's law was integrated over the cross-section of the wire. Due to their low magnetic susceptibilities, the influence of all non-current carrying materials was neglected.…”

Section: Simulations Of the Electric And Magnetic Fieldsmentioning

confidence: 99%

“…Subsequently, the particle's position as a function of time was extracted from the video data as described before (see the ESI † for a short description of the data analysis). 45 This system can be described by an actuation force in the x/yplane, F → act,x/y , and the viscous drag force, F…”

Section: Force Calculationmentioning

confidence: 99%

On-chip electromagnetic tweezers – 3-dimensional particle actuation using microwire crossbar arrays

2016

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Emerging miniaturization technologies for biological and bioengineering applications require precise control over position and actuation of microparticles. While many of these applications call for high-throughput approaches, common tools for particle manipulation, such as magnetic or optical tweezers, suffer from low parallelizability. To address this issue, we introduce a chip-based platform that enables flexible three-dimensional control over individual magnetic microparticles. Our system relies on microwire crossbar arrays for simultaneous generation of magnetic and dielectric forces, which actuate the particles along highly localized traps. We demonstrate the precise spatiotemporal control of individual particles by tracing complex trajectories in three dimensions and investigate the forces that can be generated along different axes. Furthermore, we show that our approach for particle actuation can be parallelized by simultaneously controlling the position and movement of 16 particles in parallel.

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“…Similar work exists on the on-chip manipulation of biological cells or magnetotactic bacteria. 97,98 Another microfluidic transport system combined with two integrated tapered conductors was proposed by Wirix-Speetjens et al 99,100 Maximum magnetic fields can be generated in the corners of the current-carrying tapered conductor and magnetic forces mainly orient perpendicular to the bevel and bottom edges as shown in Fig. 8(b).…”

Section: Micro-sized Integrated Magnet Systemmentioning

confidence: 99%

Configurations and control of magnetic fields for manipulating magnetic particles in microfluidic applications: magnet systems and manipulation mechanisms

2014

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The use of a magnetic field for manipulating the motion of magnetic particles in microchannels has attracted increasing attention in microfluidic applications. Generation of a flexible and controllable magnetic field plays a crucial role in making better use of the particle manipulation technology. Recent advances in the development of magnet systems and magnetic field control methods have shown that it has great potential for effective and accurate manipulation of particles in microfluidic systems. Starting with the analysis of magnetic forces acting on the particles, this review gives the configurations and evaluations of three main types of magnet system proposed in microfluidic applications. The interaction mechanisms of magnetic particles with magnetic fields are also discussed.

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Actuation and tracking of a single magnetic particle on a chip

Cited by 4 publications

References 20 publications

On‐chip control of magnetic particles

On‐chip control of magnetic particles

On-chip electromagnetic tweezers – 3-dimensional particle actuation using microwire crossbar arrays

Configurations and control of magnetic fields for manipulating magnetic particles in microfluidic applications: magnet systems and manipulation mechanisms

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