Acupuncture at ST36 Exerts Neuroprotective Effects via Inhibition of Reactive Astrogliosis in Infantile Rats with Hydrocephalus

Tida, Jacqueline Atsuko; Catalão, Carlos Henrique Rocha; Garcia, Camila Araújo Bernardino; Santos, Antônio Carlos dos; Salmon, Carlos Ernesto Garrido; Lopes, Luíza da Silva

doi:10.1136/acupmed-2017-011515

Cited by 10 publications

(10 citation statements)

References 39 publications

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“…It also stimulates the differentiation of transplanted bone marrow mesenchymal stem cells (MSCs) and promotes corticospinal tract regeneration across injured sites in the caudal cord, with CSPG protein involvement ( Ding et al, 2013 ). Numerous studies have shown that acupuncture can restrict astrogliosis and alleviate neurological dysfunction caused by diseases such as hydrocephalus ( Tida et al, 2018 ) and cerebral ischemia ( Han et al, 2010 ; Tao et al, 2016 ; Young-Wook et al, 2019 ).…”

Section: Mechanism Of Acupuncture Therapy In Spinal Cord Injurymentioning

confidence: 99%

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Jiang¹,

Sun²,

Chen³

2022

Front. Pharmacol.

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Spinal cord injury (SCI) results from various pathogenic factors that destroy the normal structure and function of the spinal cord, subsequently causing sensory, motor, and autonomic nerve dysfunction. SCI is one of the most common causes of disability and death globally. It leads to severe physical and mental injury to patients and causes a substantial economic burden on families and the society. The pathological changes and underlying mechanisms within SCI involve oxidative stress, apoptosis, inflammation, etc. As a traditional therapy, acupuncture has a positive effect promoting the recovery of SCI. Acupuncture-induced neuroprotection includes several mechanisms such as reducing oxidative stress, inhibiting the inflammatory response and neuronal apoptosis, alleviating glial scar formation, promoting neural stem cell differentiation, and improving microcirculation within the injured area. Therefore, the recent studies exploring the mechanism of acupuncture therapy in SCI will help provide a theoretical basis for applying acupuncture and seeking a better treatment target and acupuncture approach for SCI patients.

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Section: Mechanism Of Acupuncture Therapy In Spinal Cord Injurymentioning

confidence: 99%

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Jiang¹,

Sun²,

Chen³

2022

Front. Pharmacol.

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“…Moreover, the stimulation of Zusanli has been also suggested to promote the recovery of cerebral dysfunction. 20 Collectively, we selected these above acupoints that may contribute to bi-directional regulation of gut-brain axis. Although the incidence of POCD within the first 3 days after surgery in patients received TEAS was not significantly attenuated, but the cumulative duration of POCD on POD2 and 3 was significantly decreased compared to control, which is consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study

Liu¹,

Yin²,

Li³

et al. 2021

CIA

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Background: Postoperative cognitive decline (POCD) in the old ages seriously delays the rapid recovery. Here, we aimed to investigate the effects of transcutaneous electrical acupoint stimulation (TEAS) against POCD in elderly patients undergoing laparoscopic radical colon cancer surgery, as well as the potential mechanism. Methods: A prospective, single-center, parallel-group, randomized trial was designed. A total of 100 patients (age ≥65 years) undergoing laparoscopic radical resection of colon cancer were involved and randomly divided into TEAS (Group T) and control (Group C) groups. The patients in Group T were performed with percutaneous acupoint electrical stimulation in bilateral Hegu, Neiguan and Zusanli points from 30 minutes before anesthesia induction to the end of surgery. A Z-score based on Mini-Mental State Exam (MMSE) was used to assess the incidence of POCD. The levels of serum IL-6, hs-CRP, CGRP at 0 min before TEAS (T0), 1 h after beginning of surgery (T1) and the end of surgery (T2) were evaluated. Results: Our data showed that the cumulative duration of POCD on postoperative day 2 and 3 in Group T was significantly decreased compared to Group C (P < 0.05). Compared with T0, the levels of serum IL-6, hs-CRP, and CGRP in both Group T and C were statistically elevated at T1 and T2 (P < 0.05). Moreover, the levels of serum IL-6 and hs-CRP were decreased, but the level of CGRP was increased in Group T compared to Group C at T1 and T2 (P < 0.05). Conclusion: TEAS is associated with a lower cumulative duration of POCD in elderly patients undergoing laparoscopic radical colon cancer surgery, which may be related to the regulation of inflammatory factors and neuropeptides interacted with gut-brain axis.

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“…The mechanism of how acupuncture could improve the symptoms of hydrocephalus is still unknown. In the animal model of hydrocephalus [ 59 ], hydrocephalic rats treated with acupuncture at ST36 performed better in motor behavior and had a reduction in reactive astrocyte cell density in the corpus callosum and external capsule. These findings indicate that acupuncture at ST36 has a neuroprotective potential mediated by inhibition of astrogliosis [ 57 59 ].…”

Section: Ultimodality Treatment For Idiopathic Normal Pressure Hydroc...mentioning

confidence: 99%

“…In the animal model of hydrocephalus [ 59 ], hydrocephalic rats treated with acupuncture at ST36 performed better in motor behavior and had a reduction in reactive astrocyte cell density in the corpus callosum and external capsule. These findings indicate that acupuncture at ST36 has a neuroprotective potential mediated by inhibition of astrogliosis [ 57 59 ]. Laboratory studies also demonstrated that acupuncture regulates cerebral blood flow and metabolism.…”

Section: Ultimodality Treatment For Idiopathic Normal Pressure Hydroc...mentioning

confidence: 99%

Diagnosis and treatment for normal pressure hydrocephalus

Tsai

Tseng

et al. 2022

Tzu Chi Medical Journal

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Idiopathic normal pressure hydrocephalus (iNPH), albeit characterized by gait impairment, cognitive decline, and urinary incontinence, in clinical diagnosis is poorly defined and is usually coexistent with other neurodegenerative diseases. Surgical operation with shunt implantation is the primary treatment but leads to variable outcomes. Recent studies demonstrated that the pathophysiology of iNPH may include both preceding cerebrovascular events and concomitant Alzheimer's dementia or dopaminergic degenerative neuropathology in patients’ brain. These factors not only help differentiate iNPH from its mimics but also associated with the extent of symptomatic improvement after surgery. In this review, we examined these mechanisms underlying the development of iNPH and the beneficial effects of shunt surgery. Furthermore, the increasing identification and importance of biomarkers from cerebrospinal fluid and neural imaging could also predict the responsiveness of treatment. Finally, these progresses suggest that combination therapy would be necessary for iNPH treatment in the future.

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Acupuncture at ST36 Exerts Neuroprotective Effects via Inhibition of Reactive Astrogliosis in Infantile Rats with Hydrocephalus

Abstract: These findings indicate that acupuncture at ST36 has a neuroprotective potential mediated, in part, by inhibition of astrogliosis.

Cited by 10 publications

References 39 publications

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study

Diagnosis and treatment for normal pressure hydrocephalus

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