Acupuncture points for treating Parkinson’s disease based on animal studies

Kwon, Sunoh; Seo, Byung-Kwan; Kim, Seungtae

doi:10.1007/s11655-016-2525-y

Cited by 17 publications

(9 citation statements)

References 23 publications

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“…Acupoints play important roles in reliving the symptoms of PD. Yanglingquan (GB 34), Zusanli (ST36), Fengfu (GV16), Taichong (LR 3), Baihui (GV20), and Dazhui (GV14) acupoints have frequently been investigated for the effectiveness for treating PD [33]. In our study, Baihui (GV20) and Sishencong (EX-HN1) were selected as main points.…”

Section: Discussionmentioning

confidence: 99%

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Lü

Liu

Tian

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The objective of this study was to explore the neuroprotective effect of moxibustion on rats with Parkinson’s disease (PD) and its mechanism. A Parkinson’s disease model was established in rats using a two-point stereotactic 6-hydroxydopamine injection in the right substantia nigra (SN) and ventral tegmental area. The rats received moxibustion at the Baihui (GV20) and Sishencong (EX-HN1) acupoints for 20 minutes, six times a week, for 6 weeks. The right SN tissue was histologically and immunohistochemically examined. Differentially expressed genes (DEGs) were identified through RNA sequencing. In addition, the levels of tyrosine hydroxylase (TH), glutathione peroxidase 4 (GPX4), and ferritin heavy chain 1 (FTH1) in SN were measured. In comparison to the model group, the moxibustion group showed a significantly greater TH immunoreactivity and a higher behavioural score. In particular, moxibustion led to an increase in the number and morphological stability of SN neural cells. The functional pathway analysis showed that DEGs are closely related to the ferroptosis pathway. GPX4 and FTH1 in the SN were significantly overexpressed in the moxibustion-treated rats with PD. Moxibustion can effectively reduce the death of SN neurons, decrease the occurrence of ferroptosis, and increase the TH activity to protect the neurons in rats with PD. The protective mechanism may be associated with suppression of the ferroptosis.

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Section: Discussionmentioning

confidence: 99%

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Lü

Liu

Tian

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Acupuncture is widely used in East Asia and considered an alternative therapy for PD [11], although recent studies have shown that acupuncture treatment has neuroprotective effects and alleviates behavioral dysfunctions in a PD mouse model [12, 13]. And recently, acupuncture has been suggested as a possible therapeutic tool for treatment of neurodegenerative diseases by inducing neurogenesis [14].…”

Section: Introductionmentioning

confidence: 99%

Acupuncture Stimulation at GB34 Restores MPTP‐Induced Neurogenesis Impairment in the Subventricular Zone of Mice

Jeon

Ryu

Kim

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Adult neurogenesis has recently been considered a new therapeutic paradigm of Parkinson's disease. In this study, we investigated whether acupuncture restores 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced impaired neurogenesis in the subventricular zone (SVZ). Male C57BL/6 mice were given 30 mg/kg of MPTP intraperitoneally once a day for 5 days, after which they were intraperitoneally injected with 50 mg/kg of bromodeoxyuridine (BrdU) and given acupuncture stimulation at HT7 or GB34 for 12 consecutive days. Dopaminergic neuronal survival in the nigrostriatal pathway and cell proliferation in the SVZ was then evaluated by immunostaining. MPTP administration induced dopaminergic neuronal death in the nigrostriatal pathway, which was suppressed by acupuncture stimulation at GB34. MPTP administration also suppressed the number of BrdU-positive cells and glial fibrillary acidic protein/BrdU-positive cells and increased the number of doublecortin/BrdU-positive cells in the SVZ, which were restored by acupuncture stimulation at GB34. These results indicate that acupuncture stimulation at GB34 restores MPTP-induced neurogenesis impairment.

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“…Acupuncture at LR-3 can not only reduce depression but also treat some brain diseases [ 30 , 63 ]. ST-36 is used to relieve pain, numbness, and dysfunctions of the digestive system, restricted movement, and to strengthen the entire body [ 27 ]. Our study focused on the NMS of Parkinson’s disease, including depression, gastrointestinal dysfunction, et al This complex disease requires the joint application of multiple acupoints, and the selection of these four acupoints is also in line with the clinical practice of traditional Chinese medicine.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture alleviates Parkinson disease and regulates the expression of brain-gut peptides

Min

et al. 2020

Exp. Anim.

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The non-motor symptoms (NMS) of Parkinson’s disease (PD) are found in more than 90% of patients with PD. Here, we explored the effects of electroacupuncture (EA) stimulation at Zhong wan (CV-12), Qihai (RN-7), Zusanli (ST-36) and Taichong (LR-3) on NMS and brain-gut peptides of PD. We found that EA intervention alleviated the motor deficit induced by 6-OHDA in rats indicated by the decreased abnormal involuntary movements (AIMs) scores and the net number of rotations and increased cylinder test grade. It also improved the spatial memory and attenuated anxiety-like and depression of PD model rats. EA treatment significantly inhibited neuronal apoptosis in PD model animals, as demonstrated by the increased number of TH positive cells and reduced number of apoptotic cells in the substantia nigra. The expression of cleaved caspase-3 and cleaved PARP in PD model rats was markedly suppressed by EA stimulation. Moreover, EA remarkably inhibited the inflammatory response in PD model rats, as revealed by the decreased levels of TNF-α, IL-1β, and COX-2 mRNA expression. It also attenuated the oxidative stress in rats, as indicated by the increased levels of SOD and GSH and the decreased level of MDA. EA treatment contributed to alleviating PD by regulating brain-gut peptides in rats, such as NPY, CCK, SST, GAS, and PYY. In conclusion, EA stimulation at CV-12, RN-7, ST-36, and LR-3 effectively alleviates the NMS of PD partly through regulating the levels of brain-gut peptides.

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Acupuncture points for treating Parkinson’s disease based on animal studies

Cited by 17 publications

References 23 publications

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Acupuncture Stimulation at GB34 Restores MPTP‐Induced Neurogenesis Impairment in the Subventricular Zone of Mice

Electroacupuncture alleviates Parkinson disease and regulates the expression of brain-gut peptides

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