Acute and chronic effects of dinner with alcoholic beverages on nitric oxide metabolites in healthy men

Sierksma, Aafje; Gaag, M.S. van der; Grobbee, Diederick E.; Hendriks, H.

doi:10.1046/j.1440-1681.2003.03863.x

Cited by 11 publications

(8 citation statements)

References 18 publications

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“…Food intake acutely and transiently increased serum NOx concentrations, an effect that was slightly attenuated if combined with alcoholic beverages. Chronic moderate alcohol consumption had no effect on the serum NOx concentration 37) .…”

Section: Discussionmentioning

confidence: 79%

Serum Oxidant and Antioxidant Levels in Diesel Exposed Toll Collectors

Arbak¹,

Yavuz

Bukan

et al. 2004

Journal of Occupational Health

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Serum Oxidant and Antioxidant Levels in Diesel Exposed Toll Collectors: Peri ARBAK, et al. Department of Chest Diseases, Abant Izzet Baysal University, Duzce School of Medicine, Turkey-It has been suggested that exposure to diesel exhaust may lead to adverse effects due to the generation of oxidants. To evaluate the end products of oxidative stress in DE exposure, toll collectors who are considered a high risk group in regard to occupational toxins were compared to controls who had office-based occupations in the same company in this cross sectional study. A total of 38 toll collectors constituted the study group. All subjects were male. The toll collectors and 29 controls were similar regarding age, smoking status and duration of work. All subjects underwent a clinical examination and an intervieweradministrated questionnaire regarding respiratory symptoms, past medical and occupational history, and pulmonary function tests were performed in all subjects. Serum malondialdehyde (MDA), nitrite+nitrate and vitamin E levels were measured. Toll collectors showed higher serum MDA (5.76 ± 2.15 µmol/L vs. 3.07 ± 0.76 µmol/L, p=0.0001) and nitrite+nitrate levels (96.50 ± 45.54 µmol/L vs. 19.32 ± 11.77 µmol/L, p=0.0001) than controls. Vitamin E levels were similar in toll collectors and controls (10.57 ± 3.44 mg/L and 9.72 ± 2.44 mg/L, respectively, p=0.267). There was no difference between groups in terms of the findings of clinical examinations and respiratory symptoms. In pulmonary function parameters, only peak expiratory flow (PEF) in toll collectors was significantly lower than that of controls (88.9% predicted and 104.2% predicted, respectively, p=0.012). In conclusion, we suggest that serum MDA and nitrite+nitrate levels may be used asReceived Dec 16, 2003; Accepted May 24, 2004 Correspondence to: P. Arbak, Department of Chest Diseases, Abant Izzet Baysal University, Duzce School of Medicine, Konuralp, Duzce, 81620, Turkey (e-mail: periarbak@hotmail.com) biological markers of oxidative stress related to DE exposure, but prospective controlled clinical studies are necessary to clarify the possible association between concentrations of MDA and nitrite+nitrate and pulmonary diseases related to DE exposure. (J Occup Health 2004; 46: 281-288)

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Section: Discussionmentioning

confidence: 79%

Serum Oxidant and Antioxidant Levels in Diesel Exposed Toll Collectors

Arbak¹,

Yavuz

Bukan

et al. 2004

Journal of Occupational Health

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“…The beverage, which was made from vinegar and garlic, can be used to promote the same mechanism for reduction of NO metabolites. One study showed that after food consumption at dinner, the intake of beverages, especially alcoholic beverages, caused an increase of NO, but regular use reduces this effect (Sierksma, Van Der Gaag, Grobbee, & Hendriks, 2003). Gingerols and shogaols are bitter phenolic composites which are present in ginger and have antiinflammatory effects (Venkatesha, Berman, & Moudgil, 2011).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of new beverage made of dates vinegar and garlic juice in improving serum lipid profile parameters and inflammatory biomarkers of mildly hyperlipidemic adults: A double-blinded, randomized, placebo-controlled study

Ali

Ayim

et al. 2018

J Food Biochem

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A beverage made from date vinegar and garlic juice was recently developed for use by people who wish to attain maximum quantities of both vinegar and polyphenols for their health and do not like to use vinegar and garlic directly in their daily diet. Fifty hyperlipidemic adults consumed two cups (500 mL) of either the new beverage or a placebo daily over a period of 7 weeks. Plasma lipids, inflammatory biomarkers, urea, creatinine, potassium, and β‐carotenoid concentrations were measured before and after each treatment. A recommended dose of 500 mL of the new beverage reduced total cholesterol (TC) (260.10 ± 17.9 to 198.90 ± 17.31 mg/dL) and C‐reactive protein (CRP) (8.04 ± 1.34 to 4.45 ± 1.42 mg/L) along with heart rate and mean blood pressure. These outcomes indicate that the new beverage improved the concentration of lipids and inflammatory biomarkers, and the new beverage is beneficial for people who are worried about hypertension. Practical applications Dietary therapy is the primary step in the treatment of hyperlipidemia. Dates, compared with different fruits, are a rich source of phenolic compounds. Researchers have claimed that extract of date fruit is effective in improving lipid profile parameters. Similarly, evidence from other studies has indicated that garlic can bring about the regulation of blood cholesterol along with the improvement of fibrinolytic activity and decrement of blood pressure. Thus, this study will provide a possible source of phenolic compounds and present a latent approach to the avoidance of hyperlipidemia and hypertension. This new beverage is suggested as a dietary supplement for the promotion of a healthy heart.

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“…FMD depends on production of NO and other vasodilators by the endothelium, and inflammation have the potential to impair FMD by reducing the bioavailability of NO (29). An 11% decrease in serum concentration of NO metabolites (nitrate and nitrite) has been demonstrated when measured in healthy men 1 h after dinner taken with alcoholic beverages (30). As NO levels are influenced by nitrate-rich foods and alcoholic beverages, they were measured when they had reached a steady-state plasma concentration (after at least 14 h of fasting).…”

Section: Discussionmentioning

confidence: 99%