Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs. an other ivy leaves extract

Cwientzek, Ute; Ottillinger, Bertram; Arenberger, Petr

doi:10.1016/j.phymed.2011.06.014

Cited by 64 publications

(66 citation statements)

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“…Four RCTs were identified in which an ivy/primrose/thyme-based preparation was used to treat patients' cough symptoms [34,35,36,37]. These studies included a total of 1,428 patients with an average of 357 participants in each study.…”

Section: Resultsmentioning

confidence: 99%

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Herbal Medicine for Cough: a Systematic Review and Meta-Analysis

et al. 2015

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Background: The aim of this review was to systematically assess the literature on herbal medicine for cough as a symptom of upper respiratory tract infections and common cold. Methods: The Cochrane Library, Scopus, MEDLINE/PubMed, and Embase were searched through March 2012 for RCTs testing the effects of herbal medicine for cough. Risk of bias was assessed using the Cochrane tool. Results: 34 RCTs (N = 7,083) on Pelargonium sidoides (11 RCTs), Echinacea (8 RCTs), Andrographis paniculata (6 RCTs), ivy/primrose/thyme (4 RCTs), essential oils (4 RCTs) and bakumondoto (1 RCT) were included. Controls were mainly placebo. Most studies had a low risk of bias. The meta-analysis revealed strong evidence for A. paniculata (SMD = -1.00, 95% CI = -1.85, -0.15; P<0.001) and ivy/primrose/thyme (RR = 1.40, 95% CI = 1.23, 1.60; P<0.001) in treating cough; moderate evidence for P. sidiodes (RR = 4.60; 95% CI = 2.89,7.31; P<0.001), and limited evidence for Echinacea (SMD = -0.68; 95% CI = -1.32, -0.04; P = 0.04). Conclusion: This review found strong evidence for A. paniculata and ivy/primrose/thyme-based preparations and moderate evidence for P. sidoides being significantly superior to placebo in alleviating the frequency and severity of patients' cough symptoms. Additional research, including other herbal treatments, is needed in this area.

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Section: Resultsmentioning

confidence: 99%

“…One study compared the effects of a combination of 2 herbal medications, but had no placebo-based control group [36]. The remaining studies compared active agents with a placebo.…”

Section: Resultsmentioning

confidence: 99%

Herbal Medicine for Cough: a Systematic Review and Meta-Analysis

et al. 2015

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“…I did not include many double-blind non-inferiority active comparator controlled studies, if efficacy of "active control" was not proven, e.g., [29,30]. All (published) double-blind RCT's showing significant efficacy over placebo.…”

Section: Methods and Resultsmentioning

confidence: 99%

Phytotherapy in acute bronchitis: what is the evidence?

Kardos¹

2015

Clin Phytosci

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Background: Acute bronchitis, frequently emerging with the common cold is one of the most frequent causes of primary care consultations. It is a self-limiting disease which poses both high symptom burden to individuals and high financial burden to society. It is largely a viral disease (~50 % rhinovirus infection), but no causal (antiviral) treatment exists. Antibiotics, mucoactive agents, antihistamines, antitussives, decongestants are most often used but without evidence from randomized controlled trials (RCT) for relieving symptoms or fostering recovery. Many in vitro and ex vivo studies with standardized herbal extracts did show important effects on inflammatory mediators, mucus hypersecretion, cough and bronchospasm. Moreover, several successful clinical RCT's with unique herbal compounds were published, many other are ongoing. Methods: Preliminary medline search for randomized controlled studies with herbal medicine for bronchitis. Results: Eighteen studies were found fulfilling search criteria; six were excluded due to duplicate publication, active comparator control or open design. In 2015 German cough guidelines (in preparation) at least 12 studies will provide evidence for developing recommendations for treatment of acute bronchitis. Conclusions: In conclusion, several herbal compounds achieved as first pharmaco-therapeutic remedies at all evidence for treatment of acute bronchitis/common cold. Evidence based guidelines are starting to include recommendations for treatment of acute bronchitis/common cold with dedicated phytomedicine.

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“…[18][19][20][21][22][23][24][25][26][27][28][29] Recently, a review of all trials employing the BSS until April 2012 was published. 30 Moreover, Kardos and colleagues reported of the BSS as a current example for the use of a composite scale.…”

Section: Clinical Psychometric Measures For Acute Bronchitismentioning

confidence: 99%

“…Finally, the BSS was brought to the notice of the international scientific community by over a dozen publications [13][14][15][16][17][19][20][21][22][23][24][25][26][27][28][29]34 and it was not rejected. All these arguments speak for a high content validity of the BSS.…”

Section: Content Validitymentioning

confidence: 99%