Acute Cardiovascular and Hemodynamic Responses to Low Intensity Eccentric Resistance Exercise with Blood Flow Restriction

Bazgir, Behzad; Valojerdi, Mojtaba Rezazadeh; Rajabi, Hamid; Fathi, Rouhollah; Ojaghi, Seyed Mojtaba; Meybodi, Mohammad Kazem Emami; Neto, Gabriel Rodrigues; Rahimi, Mostafa; Asgari, Alireza

doi:10.5812/asjsm.38458

Cited by 17 publications

(31 citation statements)

References 37 publications

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“…The majority of the trials (14 of 19, 74%) comparing LI-BFR with LI (i.e., comparison matched by load) showed increased BP responses in the LI-BFR group (14,16,29,85,88,125,127,128,146,155,159,167). These results were reproduced in young or middle-aged/elderly men (14,16,88,127,155,159,167) and women (125,146), and also in populations with chronic diseases (85,125).…”

Section: Studies Comparing Li-bfr With LI Free Flow Exercisementioning

confidence: 79%

“…This hypothesis is supported by several experimental and clinical studies demonstrating the role of metaboreflex activation on neural and hemodynamic responses to exercise in healthy and clinical populations (2,20,28,38,49,52,54,87,120,143,150,156). Recent studies have assessed cardiovascular responses during typical BFRT sessions (6,14,16,29,36,71,76,85,88,114,124,125,127,128,142,146,150,155,156,167). The equivocal results of these limited studies suggest that further investigation of the cardiovascular responses to BFRT are necessary and required to properly assess the cardiovascular safety of this method of exercise training.…”

Section: Introductionmentioning

confidence: 87%

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Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise

Cristina-Oliveira

Meireles

Spranger

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

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Blood flow restriction training (BFRT) is an increasingly widespread method of exercise that involves imposed restriction of blood flow to the exercising muscle. Blood flow restriction is achieved by inflating a pneumatic pressure cuff (or a tourniquet) positioned proximal to the exercising muscle before, and during, the bout of exercise (i.e., ischemic exercise). Low-intensity BFRT with resistance training promotes comparable increases in muscle mass and strength observed during high-intensity exercise without blood flow restriction. BFRT has expanded into the clinical research setting as a potential therapeutic approach to treat functionally impaired individuals, such as the elderly, and patients with orthopedic and cardiovascular disease/conditions. However, questions regarding the safety of BFRT must be fully examined and addressed before the implementation of this exercise methodology in the clinical setting. In this respect, there is a general concern that BFRT may generate abnormal reflex-mediated cardiovascular responses. Indeed, the muscle metaboreflex is an ischemia-induced, sympathoexcitatory pressor reflex originating in skeletal muscle, and the present review synthesizes evidence that BFRT may elicit abnormal cardiovascular responses resulting from increased metaboreflex activation. Importantly, abnormal cardiovascular responses are more clearly evidenced in populations with increased cardiovascular risk (e.g., elderly and individuals with cardiovascular disease). The evidence provided in the present review draws into question the cardiovascular safety of BFRT, which clearly needs to be further investigated in future studies. This information will be paramount for the consideration of BFRT exercise implementation in clinical populations.

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Section: Studies Comparing Li-bfr With LI Free Flow Exercisementioning

confidence: 79%

Section: Introductionmentioning

confidence: 87%

Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise

Cristina-Oliveira

Meireles

Spranger

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

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“…Once in a differentiation state, the mononucleated myoblasts fuse to form multinucleated myotubes, which mature into contracting myofibrils (according to ref. [ and ]).…”

Section: Biological Functions Of Taurinementioning

confidence: 99%

Taurine: A Regulator of Cellular Redox Homeostasis and Skeletal Muscle Function

Seidel

Huebbe

Rimbach

2018

Molecular Nutrition Food Res

124

118

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Taurine is a nonproteinogenic ß-aminosulfonic acid. Important dietary sources of taurine are fish and seafood. Taurine interacts with ion channels, stabilizes membranes, and regulates the cell volume. These actions confirm its high concentrations in excitable tissues like retina, neurons, and muscles. Retinal degeneration, cardiomyopathy, as well as skeletal muscle malfunction are evident in taurine-deficient phenotypes. There is evidence that taurine counteracts lipid peroxidation and increases cellular antioxidant defense in response to inflammation. In activated neutrophils, taurine reacts with hypochloric acid to form taurine chloramine, which triggers the Kelch-like ECH-associated protein 1-nuclear factor E2-related factor 1 (Keap1-Nrf2) pathway. Consequently, Nrf2 target genes, such as heme oxygenase-1 and catalase, are induced. Furthermore, taurine may prevent an overload of reactive oxygen species (ROS) directly by an inhibition of ROS generation within the respiratory chain. Taurine affects mitochondrial bioenergetics and taurine-deficient mice exhibit an impaired exercise performance. Moreover, some studies demonstrate that taurine enhances the glycogen repletion in the postexercise recovery phase. In the case of taurine deficiency, many studies observed a phenotype known in muscle senescence and skeletal muscle disorders. Overall, taurine plays an important role in cellular redox homeostasis and skeletal muscle function.

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“…The cell adhesion ligands, topological features, mechanical support, and degradability of ECM guide the morphology, proliferation, migration, differentiation, and apoptosis of cells. [7][8][9] Therefore, the scientific focus is directed at investigating biomaterials that mimic the dynamic structure and functions of natural ECM. [10][11][12] Due to their high water content, compatible mechanical properties, and resemblance to biological tissues, hydrogels are attractive candidates for developing 3D ECM mimics.…”

Section: Introductionmentioning

confidence: 99%

Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications

Gaillez

Rothe

et al. 2021

Adv Healthcare Materials

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Conductive hydrogels (CHs) are emerging as a promising and well-utilized platform for 3D cell culture and tissue engineering to incorporate electron signals as biorelevant physical cues. In conventional covalently crosslinked conductive hydrogels, the network dynamics (e.g., stress relaxation, shear shining, and self-healing) required for complex cellular functions and many biomedical utilities (e.g., injection) cannot be easily realized. In contrast, dynamic conductive hydrogels (DCHs) are fabricated by dynamic and reversible crosslinks. By allowing for the breaking and reforming of the reversible linkages, DCHs can provide dynamic environments for cellular functions while maintaining matrix integrity. These dynamic materials can mimic some properties of native tissues, making them well-suited for several biotechnological and medical applications. An overview of the design, synthesis, and engineering of DCHs is presented in this review, focusing on the different dynamic crosslinking mechanisms of DCHs and their biomedical applications.

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Acute Cardiovascular and Hemodynamic Responses to Low Intensity Eccentric Resistance Exercise with Blood Flow Restriction

Cited by 17 publications

References 37 publications

Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise

Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise

Taurine: A Regulator of Cellular Redox Homeostasis and Skeletal Muscle Function

Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications

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