Acute dacryocystitis complicated by orbital cellulitis and loss of vision: A case report and review of the literature

Alsalamah, Abrar K.; Alkatan, Hind M.; Al-Faky, Yasser H

doi:10.1016/j.ijscr.2018.07.045

Cited by 21 publications

(13 citation statements)

References 12 publications

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“…Gram-negative bacteria were found in 12.1-48.6% of lacrimal secretion samples from chronic dacryocystitis patients and 1.7-8.9% of normal conjunctival sac secretions. Similarly, anaerobic bacteria were found in 10.7-18.6% and 0-16.5% of the two types of samples, respectively [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Therefore, the results of the current study are fairly consistent with previous findings, with bacteria detected in 61.9% of the lacrimal duct secretion samples from chronic dacryocystitis patients and 50.9% of the non-infectious eye disease patients (P \ 0.05).…”

Section: Discussionmentioning

confidence: 83%

“…Patients not only suffer from excessive tear production and pain, they are also at increased risk of eye infections such as corneal ulcer and endophthalmitis after trauma or surgery because of the ongoing secretion into the conjunctival sac [2,3]. Orbital cellulitis secondary to dacryocystitis can also occur and result in abscess formation with risk of visual compromise [4]. Antibiotic therapy still plays an important role in the treatment of chronic dacryocystitis, with the selection of antibiotics based on bacterial culture and drug sensitivity testing.…”

Section: Introductionmentioning

confidence: 99%

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Bacterial agents and changes in drug susceptibilities in cases of chronic dacryocystitis, Southern China

et al. 2020

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Purpose This study aimed to determine the susceptibility and the changes of bacterial agents of chronic dacryocystitis and determine the risk factors for bacterial prevalence and drug sensitivity to provide a reference for clinical selection of antibiotics. Methods A case-control study was conducted using 112 patients with chronic dacryocystitis and 112 patients with non-infectious ophthalmopathy between August 2017 and April 2018. Lacrimal and conjunctival sac secretions were cultured for aerobic and anaerobic bacteria. Forty-five patients with chronic dacryocystitis between November 2014 and November 2015 were also included. Results Positive bacterial cultures were obtained from 61.9% and 50.9% of chronic dacryocystitis and non-infectious ophthalmopathy patients, but the detection rates for pathogenic bacteria were 18.3% and 2.7%, respectively (P [ 0.001). Gram-negative and anaerobic bacteria were significantly more prevalent in the patient group compared with the control group (P = 0.001 and 0.005, respectively). Bacteria were detected at a significantly higher rate in patients with irritant symptoms (itch or foreign-body sensation) than in those without (OR = 9.333, P = 0.002), particularly Staphylococcus (OR = 9.783, P = 0.002). 11.6% (10/86) and 55.8% (48/86) showed resistance to levofloxacin and tobramycin, respectively. Compared with three years ago, the detection rate for Grampositive cocci decreased from 51.1% to 27.8% (v 2 = 8.054, P = 0.005) Conclusions Gram-positive cocci, Gram-negative bacilli, and anaerobic bacteria were the predominant pathogens. The prevalence of Gram-positive bacteria in cases of chronic dacryocystitis is decreasing.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Bacterial agents and changes in drug susceptibilities in cases of chronic dacryocystitis, Southern China

et al. 2020

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“…However, due to the lack of knowledge on its etiology and pathogenesis, there has not been effective etiology therapy for chronic dacryocystitis. In some cases treatment of dacryocystitis could be delayed and orbital cellulitis secondary to dacryocystitis and following abscess formation can even lead to visual compromise ( Alsalamah et al, 2018 ). Thereafter, it’s of great importance to make out the mechanism of the disease and work out more precise etiological therapy.…”

Section: Discussionmentioning

confidence: 99%

Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis

Liu

Zhang

et al. 2022

Front. Genet.

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This study was designed to identify differently expressed circular RNAs (circRNAs) and investigate their potential roles in lacrimal sacs from patients with chronic dacryocystitis. The lacrimal sac samples of three chronic dacryocystitis patients and three control subjects were collected for RNA sequencing after ribosomal RNA was depleted. Differently expressed circRNAs and messenger RNAs (mRNAs) were used for co-expression analysis. CircRNA-microRNA (miRNA)-mRNA interaction network were also established by miRanda software. Meanwhile, pathway and functional enrichment analysis were conducted for the down- and up-regulated mRNAs in the circRNA-mRNA co-expression network. The expression levels of circRNAs and mRNAs in chronic dacryocystitis and control samples were validated by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). In all the 3,909 circRNAs predicted through RNA sequencing, 25 circRNAs (20 up-regulated and 5 down-regulated) expressed differently in chronic dacryocystitis samples. Besides, there identified 1,486 differentially expressed mRNAs. Of these differently expressed circRNAs and mRNAs, eight were validated by qRT-PCR, including MYH2, DSP, CD27, CCL5, FN1, has_circ_0004792, has_circ_0001062, and has_circ_0115476. Gene Ontology (GO) analysis indicated that the majority of altered mRNAs in this co-expression network were involved in immune system processes and meanwhile Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that these altered expressed mRNAs were also amplified in bacterial invasion of epithelial cells, both of which were thought to be involved in the pathogenesis of chronic dacryocystitis. In the circRNA-miRNA-mRNA interaction network, six circRNAs were found to be related to Th1 and Th2 cell differentiation, which was closely associated with the development of chronic dacryocystitis. This study identified statistically significant differences between circRNAs and mRNAs of lacrimal sac samples of chronic dacryocystitis patients and control individuals and provides novel insight into the regulatory mechanism of circRNAs, miRNAs, and mRNAs in the pathogenesis of chronic dacryocystitis.

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“…Posterior extension in the form of orbital cellulitis and orbital abscess can happen if the posterior barriers weaken. [ 2 15 16 17 18 19 20 21 22 23 24 25 26 27 ] Various theories for posterior extension of acute dacryocystitis have been suggested. Repeat episodes of acute dacryocystitis can cause distension of the soft tissues, and hence, weaken the posterior barriers, which then predisposes to orbital spread of the infection.…”

Section: A Cute D Acryocystitis With ...mentioning

confidence: 99%

“…Direct invasion of the virulent organism, toxic vasculitis occluding fine pial feeder vessels, or mass effect on optic nerve can cause ischemia, leading to optic neuritis and vision loss. [ 18 27 29 30 31 32 ]…”

Section: A Cute D Acryocystitis With ...mentioning

confidence: 99%

Orbital involvement in lacrimal drainage disorders

Bothra

Ali

2021

Saudi Journal of Ophthalmology

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Lacrimal sac is situated anterior to the orbital septum, which acts as a barrier, thus limiting the posterior migration of the pathologies affecting the lacrimal drainage system. Certain pathologies can breach this barrier and secondarily involve the orbit causing significant clinical manifestations. This posterior migration of pathology also has a significant influence on the management and outcomes. The present paper will discuss the lacrimal pathologies which secondarily involve the orbit and its influence on the management and outcomes.

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Acute dacryocystitis complicated by orbital cellulitis and loss of vision: A case report and review of the literature

Cited by 21 publications

References 12 publications

Bacterial agents and changes in drug susceptibilities in cases of chronic dacryocystitis, Southern China

Bacterial agents and changes in drug susceptibilities in cases of chronic dacryocystitis, Southern China

Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis

Orbital involvement in lacrimal drainage disorders

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