Acute Dermal Irritation Study of Six Jet Fuels in New Zealand White Rabbits: Comparison of Four Bio-Based Jet Fuels with Two Petroleum JP-8 Fuels

Sterner, Teresa R; Hurley, J. M.; Edwards, James T.; Shafer, Linda; Mattie, David R.

doi:10.21236/ada606443

2014

DOI: 10.21236/ada606443

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Acute Dermal Irritation Study of Six Jet Fuels in New Zealand White Rabbits: Comparison of Four Bio-Based Jet Fuels with Two Petroleum JP-8 Fuels

Teresa R Sterner¹,

J. M. Hurley²,

James T. Edwards³

et al.

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Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene

Mattie

Sterner

Reddy

et al. 2018

Journal of Toxicology and Environmental Health, Part A

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Fischer-Tropsch (FT) Synthetic Paraffinic Kerosene (SPK) jet fuel is a synthetic organic mixture intended to augment petroleum-derived JP-8 jet fuel use by the U.S. armed forces. The FT SPK testing program goal was to develop a comparative toxicity database with petroleum-derived jet fuels that may be used to calculate an occupational exposure limit (OEL). Toxicity investigations included the dermal irritation test (FT vs. JP-8 vs. 50:50 blend), 2 in vitro genotoxicity tests, acute inhalation study, short-term (2-week) inhalation range finder study with measurement of bone marrow micronuclei, 90-day inhalation toxicity, and sensory irritation assay. Dermal irritation was slight to moderate. All genotoxicity studies were negative. An acute inhalation study with F344 rats exposed at 2000 mg/m for 4 hr resulted in no abnormal clinical observations. Based on a 2-week range-finder, F344 rats were exposed for 6 hr per day, 5 days per week, for 90 days to an aerosol-vapor mixture of FT SPK jet fuel (0, 200, 700 or 2000 mg/m). Effects on the nasal cavities were minimal (700 mg/m) to mild (2000 mg/m); only high exposure produced multifocal inflammatory cell infiltration in rat lungs (both genders). The RD (50% respiratory rate depression) value for the sensory irritation assay, calculated to be 10,939 mg/m indicated the FT SPK fuel is less irritating than JP-8. Based upon the proposed use as a 50:50 blend with JP-8, a FT SPK jet fuel OEL is recommended at 200 mg/m vapor and 5 mg/m aerosol, in concurrence with the current JP-8 OEL.

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Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene

Mattie

Sterner

Reddy

et al. 2018

Journal of Toxicology and Environmental Health, Part A

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show abstract

Toxicity and human health assessment of an alcohol-to-jet (ATJ) synthetic kerosene developed under an international agreement with Sweden

Mattie

Wong²,

Mumy³

et al. 2023

Journal of Toxicology and Environmental Health, Part A

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Characterization of the Ultrafine and Black Carbon Emissions from Different Aviation Alternative Fuels

Chan

Chishty

Davison

et al. 2015

SAE Int. J. Fuels Lubr.

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Acute Dermal Irritation Study of Six Jet Fuels in New Zealand White Rabbits: Comparison of Four Bio-Based Jet Fuels with Two Petroleum JP-8 Fuels

Cited by 3 publications

References 3 publications

Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene

Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene

Toxicity and human health assessment of an alcohol-to-jet (ATJ) synthetic kerosene developed under an international agreement with Sweden

Characterization of the Ultrafine and Black Carbon Emissions from Different Aviation Alternative Fuels

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