Acute effects of cocaine on cochlear function

Shivapuja, Bhagyalakshmi G.; Gu, Zhiping; Saunders, Samuel S.; Quirk, Wayne S.

doi:10.1016/0378-5955(93)90114-g

Cited by 10 publications

(12 citation statements)

References 24 publications

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“…In the study carried out by Perez, Kós e Frota (2006) 25 29 women (G2): higher auditory thresholds for frequencies of 250, 500, 4000, 6000 and 8000 Hz and the absence of TOAEs. The agreement of these results with the studies with guinea pigs exposed to cocaine 11,17 infers that crack and cocaine may be potentially ototoxic to the cochlea.…”

Section: Discussionsupporting

confidence: 80%

“…These results might be related to the kind of drug that was used, once studies on rats show that cocaine causes decreased blood flow in the cochlea and, with this sensitive structure to hypoxia, the organ of Corti and spiral ganglion were susceptible to degenerative damages 11,17,20 .…”

Section: Discussionmentioning

confidence: 99%

“…The effects of drug use on the hearing, more specifically on the cochlea, have been described in isolated case reports and also in studies with guinea pigs [8][9][10][11]17,18 .…”

Section: Discussionmentioning

confidence: 99%

“…Thus, TOAE in users of crack/cocaine, could be explained as a result of deterioration of hair cells, resulting from prolonged hypoxia (use superior to 10 years) caused by drug use 11,17 .…”

Section: Discussionmentioning

confidence: 99%

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Limiares auditivos tonais, emissões otoacústicas e sistema olivococlear medial de ex-usuários de drogas

2014

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Objetivos analisar se o uso de drogas ilícitas pode interferir nos sistemas auditivos periférico e central. Métodos a amostra foi composta por 17 indivíduos distribuídos conforme o tipo de droga mais consumida: 10 indivíduos no grupo maconha (G1) e sete no grupo crack/cocaína (G2). Os grupos foram subdivididos segundo o tempo de uso de drogas: um a cinco, seis a 10 e mais que 15 anos. Foram avaliados por meio de anamnese, audiometria tonal liminar, imitânciometria, emissões otoacústicas transientes (EOAT) e efeito supressor das EOAT. Resultados comparando os limiares tonais do G1 e G2, observaram-se limiares elevados para o G2, com diferença estatisticamente significante no grupo de um a cinco anos para 250, 500, 6000 e 8000Hz na orelha direita e de seis a 10 anos para 4000 e 8000Hz na orelha esquerda. Para usuários por mais que 15 anos, observou-se limiares superiores a 25dBNA de 3000 a 8000Hz na orelha direita. Nas EOAT e efeito supressor das EOAT não houve diferença estatisticamente significante entre G1 e G2 e entre os tempos de uso das drogas. O G1 apresentou relação sinal/ruído das EOAT superior ao G2. O efeito supressor das EOAT esteve presente em 79% das orelhas avaliadas. Conclusão na amostra estudada, o crack/cocaína apresentou efeito mais deletério sobre o sistema auditivo do que a maconha. O maior tempo de uso de drogas influenciou nos resultados do G1. O uso de drogas ilícitas não provocou alterações no SOCM.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

“…The effects of drug use on the hearing, more specifically on the cochlea, have been described in isolated case reports and also in studies with guinea pigs [8][9][10][11]17,18 .…”

Section: Discussionmentioning

confidence: 99%

“…Thus, TOAE in users of crack/cocaine, could be explained as a result of deterioration of hair cells, resulting from prolonged hypoxia (use superior to 10 years) caused by drug use 11,17 .…”

Section: Discussionmentioning

confidence: 99%

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Limiares auditivos tonais, emissões otoacústicas e sistema olivococlear medial de ex-usuários de drogas

2014

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“…[19][20][21][22] Similar to MDMA, cocaine blocks the reuptake of dopamine and serotonin at the presynaptic membranes. 23 A few cases of temporary severe sensorineural hearing loss after the use of cocaine or a combination of drugs are described in the literature. [24][25][26] Finally, smoking combined with noise exposure is hypothesized to correlate with hearing thresholds and NIHL.…”

mentioning

confidence: 99%

Association of Behavior With Noise-Induced Hearing Loss Among Attendees of an Outdoor Music Festival

Kraaijenga

Munster

Zanten

2018

JAMA Otolaryngol Head Neck Surg

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IMPORTANCETo date, factors associated with noise-induced hearing loss at music festivals have not yet been analyzed in a single comprehensive data set. In addition, little is known about the hearing loss-associated behavior of music festival attendees.OBJECTIVES To assess which factors are associated with the occurrence of a temporary threshold shift (TTS) after music exposure and to investigate the behavior of music festival attendees. MAIN OUTCOMES AND MEASURESThe primary outcome was a TTS on a standard audiogram for the frequencies 3.0-and 4.0-kHz. Multivariable linear regression was performed to determine which factors are associated with a TTS. A questionnaire on behavior, hearing, and tinnitus was distributed to the participants before and after the festival visit. CONCLUSIONS AND RELEVANCE The present study identified nonuse of earplugs, use of alcohol and drugs, and male sex as associated with a TTS at an outdoor music festival. Physicians should consider these factors to raise awareness about the combined risk of attending music festivals without using earplugs while consuming alcohol and/or drugs. The intention to use earplugs was correlated with the loudness and appreciation of music with earplugs, which may advocate for the use of personalized earplugs.

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Sudden bilateral sensorineural hearing loss after intravenous cocaine injection: A case report and review of the literature

et al. 2009

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Little is known about the effects of intravenous abuse of cocaine, especially on the inner ear. We report on a 26-year-old man who presented to our outpatient department with a sudden severe hearing loss after intravenous injection of cocaine. The audiogram on admission showed symmetric air conduction levels up to 80 dB at 4 kHz. After treatment with intravenous sodium chloride, prednisolone, and pentoxifylline, the audiogram 2 days later showed a bilateral normacusis. A review of the literature on the topic is given and possible reasons for inner ear damages caused by cocaine are discussed.

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Acute effects of cocaine on cochlear function

Cited by 10 publications

References 24 publications

Limiares auditivos tonais, emissões otoacústicas e sistema olivococlear medial de ex-usuários de drogas

Limiares auditivos tonais, emissões otoacústicas e sistema olivococlear medial de ex-usuários de drogas

Association of Behavior With Noise-Induced Hearing Loss Among Attendees of an Outdoor Music Festival

Sudden bilateral sensorineural hearing loss after intravenous cocaine injection: A case report and review of the literature

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