Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis

Dobrin, Robert S.; Vernier, Robert L.; Fish, Alfred J.

doi:10.1016/0002-9343(75)90390-3

Cited by 317 publications

(191 citation statements)

References 40 publications

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“…The pa- Urine beta-2 microglobulin (µg/gCr) 9,522 3,960 < 600 WBC = white blood cell count; Hb = hemoglobin; CRP = C-reactive protein; ESR = erythrocyte sedimentation rate Letters to the Editors TINU syndrome was originally described by Dobrin et al in 1975. 1 Although its cause remains unknown, previous studies suggest that this syndrome is a cell-and humoral-mediated autoimmune disease against common unknown antigens within the kidney and uvea.…”

Section: To the Editorsmentioning

confidence: 99%

Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine

Sawai¹,

Shimizu²,

Sakai³

et al. 2016

J Pediatr Ophthalmol Strabismus

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Section: To the Editorsmentioning

confidence: 99%

Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine

Sawai¹,

Shimizu²,

Sakai³

et al. 2016

J Pediatr Ophthalmol Strabismus

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“…In 1975, Dobrin et al Described two adolescent females with acute eosinophilic tubulointerstitial nephritis; bilateral anterior uveitis; high ESR; hypergammaglobulinemia and bone marrow and lymph node granulomas [14]. In 1985, this disease was named tubulointerstitial nephritis and uveitis syndrome (TINU) syndrome by Grefer and Dusek et al [15,16].…”

Section: Discussionmentioning

confidence: 99%

Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome, Two New Cases and Review of the Literature

Laidoudi¹,

Hakem²

2016

J Nephrol Ther

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Case 1: A 25 year-old woman, presented with asthenia; weight loss; severe hypertension and acute unilateral anterior uveitis. She had also proteinuria; hematuria; aciduria; kidney failure and grade I hypertensive retinopathy. Kidney biopsy showed a non caseating granuloma in the interstitial tissue, and tubulointerstitial nephritis (TIN) with granulomatous lesions in the medullary parenchyma. All explorations were negative but QuantiFERON was 10 times normal without koch's bacillus. No other sites of granulomas. The patient partially responded to corticoid treatment. She replased after untimely stopping corticosteroids. Corticosteroid-sparing was provided by mycophenolate mofetil.Case 2: A 46 year-old patient, with family history of mother who died of CKD, presented with recurrent anterior uveitis, kidney failure, proteinuria, and inflammatory syndrome, research of infectious agents or auto-immunity origin was negative. Renal biopsy showed TIN lesions in subacute stage; biopsy of the salivary glands showed stage III chronic lymphocytic sialadenitis without Sjogren syndrome or sarcoidosis. The patient received corticosteroid treatment. Discussion:The presence of TIN, recurrent anterior uveitis, no notion of drug intake, response to corticosteroids and exclusion of other diagnoses leads to TINU syndrome. Positivity of Quantiferon is explained by the fact that TINU syndrome is associated with high serological markers in the absence of their corresponding diseases, and presence of chronic lymphocytic sialadenitis explained by these immunological disorders without Sjogren syndrome, Both patients remained well without recurrence of uveitis 2 and 6 years later respectively. Conclusion:TINU syndrome is secondary to immunological disorders as evidenced interstitial infiltrate of the renal parenchyma, the inflammatory disease of the uvea and good response to corticosteroid therapy.

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“…First described by Dobrin 27 years ago, this condition has associated features of both tubulo-interstitial nephritis and anterior uveitis (AU). [3][4][5][6][7] Mandeville et al 1 have set out the diagnostic criteria for 'definite' TINU, which requires the presence of histopathologically confirmed AIN and typical uveitis. 1 There have been multiple reports in the literature with TINU syndrome-associated posterior segment involvement.…”

Section: Commentmentioning

confidence: 99%

Tubulo-interstitial nephritis and uveitis with bilateral optic disc oedema

Menezo

Ram

2004

Eye

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Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis

Cited by 317 publications

References 40 publications

Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine

Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine

Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome, Two New Cases and Review of the Literature

Tubulo-interstitial nephritis and uveitis with bilateral optic disc oedema

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