Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine

Sawai, Toshihiro; Shimizu, Masaki; Sakai, Tomoyuki; Yachie, Akihiro

doi:10.3928/01913913-20160405-04

Cited by 11 publications

(12 citation statements)

References 3 publications

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“…Furthermore, in patients with acute interstitial nephritis, elevated anti-mCRP antibodies may predict the subsequent development of uveitis [107]. This is consistent with clinical evidence, as the two patients reported by Sawai et al had interstitial nephritis and subsequently developed uveitis [42]. Therefore, the kidneys may be the primary target of a sequential process that triggers an inflammatory cascade with secondary effects on the eye.…”

Section: Tubulointerstitial Nephritis and Uveitis (Tinu) Syndrome And...supporting

confidence: 77%

“…Sawai et al reported the cases of two patients who developed TINU following vaccination with the HPV vaccine [42]. Both patients, who were previously in good health, exhibited slight elevations in serum creatinine, hemoglobin, C-reactive protein, and erythrocyte sedimentation rate, and corticosteroid therapy proved effective.…”

Section: Tubulointerstitial Nephritis and Uveitis (Tinu) Syndrome And...mentioning

confidence: 99%

See 1 more Smart Citation

Vaccines and the Eye: Current Understanding of the Molecular and Immunological Effects of Vaccination on the Eye

Zou,

Kamoi,

Zong

et al. 2024

IJMS

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Vaccination is a public health cornerstone that protects against numerous infectious diseases. Despite its benefits, immunization implications on ocular health warrant thorough investigation, particularly in the context of vaccine-induced ocular inflammation. This review aimed to elucidate the complex interplay between vaccination and the eye, focusing on the molecular and immunological pathways implicated in vaccine-associated ocular adverse effects. Through an in-depth analysis of recent advancements and the existing literature, we explored various mechanisms of vaccine-induced ocular inflammation, such as direct infection by live attenuated vaccines, immune complex formation, adjuvant-induced autoimmunity, molecular mimicry, hypersensitivity reactions, PEG-induced allergic reactions, Type 1 IFN activation, free extracellular RNA, and specific components. We further examined the specific ocular conditions associated with vaccination, such as uveitis, optic neuritis, and retinitis, and discussed the potential impact of novel vaccines, including those against SARS-CoV-2. This review sheds light on the intricate relationships between vaccination, the immune system, and ocular tissues, offering insights into informed discussions and future research directions aimed at optimizing vaccine safety and ophthalmological care. Our analysis underscores the importance of vigilance and further research to understand and mitigate the ocular side effects of vaccines, thereby ensuring the continued success of vaccination programs, while preserving ocular health.

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Section: Tubulointerstitial Nephritis and Uveitis (Tinu) Syndrome And...supporting

confidence: 77%

Section: Tubulointerstitial Nephritis and Uveitis (Tinu) Syndrome And...mentioning

confidence: 99%

Vaccines and the Eye: Current Understanding of the Molecular and Immunological Effects of Vaccination on the Eye

Zou,

Kamoi,

Zong

et al. 2024

IJMS

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“…1 Pt with recurrences after 133 months of treatment Mean follow-up period was 54.8 years TINU syndrome characterized by limited responsiveness to corticosteroid therapy and less by severe complications Sawai et al . (2016), Japan [ 43 ] 2 Two 14-year-old girls. Pt 1 had systemic symptoms and low back pain 4 days after third dose of HPV vaccination.…”

Section: Discussionmentioning

confidence: 99%

Tubulointerstitial nephritis and uveitis syndrome in an adolescent female: a case report

2021

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Background Tubulointerstitial nephritis with uveitis syndrome is a rare disease affecting mainly children and young women. Tubulointerstitial nephritis with uveitis is a diagnosis of exclusion, requiring a high degree of clinical suspicion. Studies report recent infections or certain drugs as precipitating factors of a lymphocytic oculorenal immune response. The prognosis is usually favorable with topical and systemic corticosteroid therapy. Case presentation We report a literature review and the case of a 14-year-old white girl, who presented to the ophthalmology department with features of one-sided uveitis. Upon transfer of patient to nephrological care, diagnostic work-up revealed renal involvement. Renal biopsy showed a mixed-cell and granulomatous tubulointerstitial nephritis with some noncaseating granulomas, leading to a diagnosis of tubulointerstitial nephritis with uveitis syndrome. With topical ocular and systemic corticosteroid therapy, the patients’ condition improved over several weeks. Conclusions Our case highlights the importance of early recognition and treatment of this syndrome, where cross-specialty care typically leads to a favorable outcome.

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“…After conducting a comprehensive review, a total of 51 reported cases (involving 61 patients), spanning from 1978 to 2023, have been associated with uveitis following various vaccinations (Table 1), including 4 case reports (5 patients) related to hepatitis B virus (HBV) vaccination [28][29][30][31]; 7 case reports (8 patients) related to human papillomavirus (HPV) vaccination [21][22][23][32][33][34][35]; 16 cases (18 patients) regarding uveitis after influenza vaccination [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]; 3 cases (4 patients) related to measles-mumps-rubella (MMR) vaccination [52][53][54]; 12 cases (16 patients) related to varicella zoster virus (VZV) vaccination [24][25][26][27][55][56][57][58][59][60][61][62]; 4 cases (5 patients) for yellow fever [63][64]…”

Section: General Analysis Regarding Cases Of Uveitis Post-vaccinationmentioning

confidence: 99%

“…The average age of the affected individuals was 38.5 years (range, 1-86 years), with a female predominance (female:male = 35:26). Based on the site of infection, this study included 11 cases of anterior uveitis [27,35,37,45,52,54,56,58,63], 1 case of intermediate uveitis [63], 8 cases of posterior uveitis [21,22,27,28,32,42], 3 cases of uveitis involving both anterior and intermediate segments [27,55,64], 1 case of anterior and posterior uveitis [38], and 7 cases of pan-uveitis [23,34,40,43,48,53]. Distinct types of uveitis, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE) [36,41,46,47,57], Vogt-Koyanagi-Harada syndrome (VKH) [31,39,49,51,65,66], multiple evanescent white dot syndrome (MEWDS) [30,33,50,[67][68][69][70], acute retinal necrosis (ARN) [24]…”

Section: General Analysis Regarding Cases Of Uveitis Post-vaccinationmentioning

confidence: 99%

Ocular Inflammation Post-Vaccination

Zou,

Kamoi,

Zong

et al. 2023

Vaccines

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The association between vaccines and ocular disorders has attracted significant attention in scientific research. Numerous mainstream vaccines are associated with a range of uveitis types, including anterior, intermediate, and posterior uveitis. Additionally, they are associated with distinct ocular diseases such as multifocal choroiditis, Vogt–Koyanagi–Harada (VKH) disease, acute posterior multifocal placoid pigment epitheliopathy (APMPPE), and multiple evanescent white dot syndrome (MEWDS). These ocular conditions are often transient, with a vast majority of patients experiencing improvement after steroid intervention. To date, numerous cases of vaccine-induced uveitis have been reported. This study analyzed the correlation between antiviral vaccines, including the hepatitis B virus (HBV), human papillomavirus (HPV), measles–mumps–rubella (MMR), varicella zoster virus (VZV), and influenza vaccines, and different manifestations of uveitis. This is the first comprehensive study to offer a detailed analysis of uveitis types induced by antiviral vaccines. Through an extensive database search, we found a particularly strong link between influenza vaccines, followed by VZV and HPV vaccines. While anterior uveitis is common, conditions such as APMPPE, MEWDS, and VKH are particularly notable and merit careful consideration in clinical practice. Corticosteroid treatment was effective; however, half of the observed patients did not achieve full recovery, indicating potentially prolonged effects of the vaccine.

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Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine

Cited by 11 publications

References 3 publications

Vaccines and the Eye: Current Understanding of the Molecular and Immunological Effects of Vaccination on the Eye

Vaccines and the Eye: Current Understanding of the Molecular and Immunological Effects of Vaccination on the Eye

Tubulointerstitial nephritis and uveitis syndrome in an adolescent female: a case report

Ocular Inflammation Post-Vaccination

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