Acute exposure of adult male rats to dietary phytoestrogens reduces fecundity and alters epididymal steroid hormone receptor expression

Glover, Amy; Assinder, Steve

doi:10.1677/joe.1.06709

Cited by 54 publications

(35 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the same vein, decrease in sperm motility suggests alteration of sperm maturation in the epididymis. Also, the increase in the sperm head abnormality in caffeine treated-animals is indicative of induced mutation on the sperm cells during spermatogenesis as observed by Ekaluo et al (2009), Glover and Assinder (2006) and Ikpeme et al (2010).…”

Section: Discussionmentioning

confidence: 68%

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

Ekaluo¹,

Uno²,

Ekpo³

et al. 2015

Asian J. of Clinical Nutrition

View full text Add to dashboard Cite

The attenuating potential of Trévo Dietary Supplement (TDS), a multi-herbal health drink containing 174 ingredients on caffeine-induced sperm toxicities was studied on albino rats. Thirty healthy male albino rats of 12 weeks old were divided into five groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were treated with combinations of caffeine and TDS orally. The treatment lasted for 65 days. Results indicated statistically significant (p<0.05) decreases in weight of testes and epididymis, epididymal sperm viability, motility and count in caffeine treated rats. There was a concomitant increase in sperm head abnormalities in caffeine treated rats. However, TDS effectively attenuated the caffeine induced sperm toxicities in albino rat models in a dose dependent manner.

show abstract

Section: Discussionmentioning

confidence: 68%

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

Ekaluo¹,

Uno²,

Ekpo³

et al. 2015

Asian J. of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…The discrepancy in testosterone between this study and that of Weber et al may be due to the longer exposure period used there (35 vs 24 days). No changes in testosterone concentrations have been described in adult-only exposure studies for 3 days (Glover & Assinder 2006) or 14 days (Fritz et al 2002). Therefore, increased apoptosis of spermatocytes and round spermatids did not appear to be due to disruption of the hypogonadal-pituitary-testicular axis, consistent with mechanism of action of dietary phytoestrogen in the aromatase null mouse (Roberstson et al 2002).…”

Section: Discussionmentioning

confidence: 84%

Adult-only exposure of male rats to a diet of high phytoestrogen content increases apoptosis of meiotic and post-meiotic germ cells

Assinder¹,

Davis²,

Fenwick³

et al. 2007

Reproduction

View full text Add to dashboard Cite

Apoptosis plays a critical role in regulating sperm production. Removal of androgens and gonadotropins, or estrogen administration induces germ cell apoptosis. It is hypothesized that dietary phytoestrogens increase apoptosis of developing germ cells, decreasing sperm production. This study aimed to test this in rats fed a high phytoestrogen diet only during adulthood. Male Wistar rats used in this study were offspring of females maintained on a low phytoestrogen diet prior to conception through to weaning. After weaning, juveniles were fed the same low phytoestrogen diet into adulthood. A cohort of males were transferred to a high phytoestrogen diet for 24 days and subsequently testes were collected from all animals. In the high phytoestrogen fed group, homogenization-resistant sperm counts were significantly decreased, as were epididymal sperm counts. Morphometric analysis determined round and elongated spermatid volumes to be significantly decreased, but seminiferous tubule lumen diameters to be significantly increased. TUNEL analysis determined that apoptosis of spermatocytes and round spermatids was significantly greater in the high phytoestrogen fed rats. Neither plasma gonadotropin concentrations nor testicular testosterone were altered. In conclusion, exposure of the adult male rat to a high phytoestrogen diet disrupts spermatogenesis, increasing germ cell apoptosis. This effect is independent of the hypothalamo-pituitary-testicular axis and is likely due to disruption of estrogen's actions in the testis.

show abstract

“…The gestational exposure of rats to diethylstilbestrol decreased expression of the AR mRNA and stimulated the ESR1 mRNA in the offspring (59). Exposure of adult male rats to dietary phytoestrogens reduced fecundity, and increased ESR1 and AR mRNA in the initial segment, but decreased them in the cauda of the epididymis (60). A microarray analysis of the effects of the antiestrogen fulvestrant on gene expression in the epididymis of the bonnet monkey has demonstrated that the expression of several genes involved in fluid absorption is affected by the treatment, including a reduction in aquaporin 1 and NHE3 expression (61).…”

Section: Epididymismentioning

confidence: 96%

Estrogen receptors and function in the male reproductive system

Lazari

Lucas

Yasuhara

et al. 2009

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ERα and ERβ, respectively. ESR1 and ESR2 belong to the nuclear receptor family of transcription factors. In addition to the well established transcriptional effects, estrogens can mediate rapid signaling, triggered within seconds or minutes. These rapid effects can be mediated by ESRs or the G protein-coupled estrogen receptor GPER, also known as GPR30. The effects of estrogen on cell proliferation, differentiation and apoptosis are often mediated by growth factors. The understanding of the cross-talk between androgen, estrogen and growth factors signaling pathways is therefore essential to understand the physiopathological mechanisms of estrogen action. In this review we focused on recent discoveries about the nature of the estrogen receptors, and on the signaling and function of estrogen in the male reproductive system. Arq Bras Endocrinol Metab. 2009;53(8):923-33 Keywords Estrogens; receptors, estrogen; reproduction; male resumo Durante a última década, ocorreu um avanço substancial no conhecimento da sinalização do estrógeno. Estrógenos interagem com dois receptores, ESR1 e ESR2, também conhecidos como ERα e ERβ, respectivamente. ESR1 e ESR2 pertencem à família de receptores nucleares, que funcionam como fatores de transcrição. Além dos bem estabelecidos efeitos transcricionais, os estrógenos medeiam a sinalização rápida, desencadeada dentro de segundos ou minutos. Esses efeitos rápidos podem ser mediados por ESRs ou pelo receptor de estrógeno acoplado à proteína G, GPER, também conhecido como GPR30. Os efeitos de estrógenos sobre a proliferação celular, diferenciação e apoptose são, muitas vezes, mediados por fatores de crescimento. Portanto, a compreensão da interação entre as vias de sinalização de andrógeno, estrógeno e fatores de crescimento é essencial para entender os mecanismos fisiopatológicos envolvidos na ação estrogênica. Nesta revisão, foram abordadas descobertas recentes sobre a estrutura dos receptores, a sinalização e a função do estrógeno no sistema reprodutor masculino. Arq Bras Endocrinol Metab. 2009;53(8):923-33

show abstract

Acute exposure of adult male rats to dietary phytoestrogens reduces fecundity and alters epididymal steroid hormone receptor expression

Cited by 54 publications

References 46 publications

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

Adult-only exposure of male rats to a diet of high phytoestrogen content increases apoptosis of meiotic and post-meiotic germ cells

Estrogen receptors and function in the male reproductive system

Contact Info

Product

Resources

About