Acute Genital Ulcers in a Virgin Adolescent Girl: A Case Report and Literature Review

Abstract

Acute genital ulcer (AGU) is a painful ulceration of genitalia that presents in especially virgin young women. The differential diagnosis includes venereal (sexually) and non-venereal (non-sexually) transmitted infections, non-infectious diseases, drug reactions, autoimmune conditions, traumatic causes and malignant. However, etiology and pathogenesis of AGU are still unknown. The disease is characterized by an acute onset of flu-like symptoms such as anxiety, fever, myalgia, pharyngotonsillitis, lymphadenopathy, and headache, with single or multiple, deep and painful mainly kissing ulcers on the vulva, on the inner side of labia majora. Ulcers associated with an immunologic reaction to a distant source of infection or inflammation. The aim of this article is to present a case of acute genital ulcer and discuss for documenting the natural history of AGU, as well as making a diagnosis, differential diagnosis, and treatment options.