Acute Hemolytic Anemia and Hemoglobinuria Complicating Infectious Mononucleosis

Infectious mononucleosis complicated by acute haemolytic anaemia with a positive Donath-Landsteiner reaction

“…Kostinas and Cantow (1966) studied Donath-Landsteiner reactions in 41 cases of infectious mononucleosis and all were negative. Green and Goldenberg (1960) reported a case of acute haemolytic anaemia complicating infectious mononucleosis with a positive direct Coombs test and cold agglutinins to a titre of 1:256. The Donath-Landsteiner reaction was negative.…”

“…Those most commonly described are cold agglutinins, either non-specific (Ellis, Wollenman, and Stetson, 1948;Green and Goldenberg, 1960;Fekete and Kerpelman, 1965) or with anti-i specificity (Rosenfield, Schmidt, Calvo, and McGinniss, 1965;Jenkins, Koster, Marsh, and Carter, 1965;Calvo, Stein, Kochwa, and Rosenfield, 1965;Troxel, Innella, and Cohen, 1966). A number of patients have been investigated fruitlessly for cold haemolysins of the Donath-Landsteiner type (Green and Goldenberg, 1960;Kostinas and Cantow, 1966); only one case of infectious mononucleosis with haemolytic anaemia and a positive Donath-Landsteiner reaction has actually been recorded (Ellis et al, 1948). This paper presents a second case Received for publication 28 February 1973. of this association occurring in the absence of syphilitic infection.…”

Acute Autoimmune Hemolytic Anemia Complicating Infectious Mononucleosis

“…The literature now contains approximately 50 similar cases. 3 The m\l=u"\llerianduct cyst reported here is of interest because of size, duration, symptomatology, and unusual histologic findings.…”