Acute hyperglycemia impairs IL‐6 expression in humans

Spindler, Matthew P.; Ho, Alvin M.; Tridgell, David; McCulloch-Olson, Marli; Gersuk, Vivian H.; Ni, Chester; Greenbaum, Carla J.; Sanda, Srinath

doi:10.1002/iid3.97

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…PBMC from healthy individuals with induced hyperglycemia of two hours duration showed decreased transcription of IL-6 and IL-17. Similar findings were obtained following incubation of monocytes with high glucose levels [24]. It has been reported that feeding induces an increase in the number of peritoneal macrophages secreting IL-1β and that this cytokine is closely connected with the uptake of glucose into the cells [25].…”

Section: Discussionsupporting

confidence: 80%

Glucose Modifies the Immune Interaction Between Mononuclear and Human Colon Carcinoma Cells

Djaldetti¹,

Bessler²

2017

Arch Microbiol Immunology

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Background: Glucose is one of the principal energy suppliers for normal cell development. Impaired glucose metabolism may lead to serious health and immune impediments including carcinogenesis. The question posed in the present work was if glucose, at several concentrations, affects cytokine production by normal human peripheral blood mononuclear cells (PBMC) and if glucose is able to modulate the immune balance between PBMC and colon cancer cells.Methods: PBMC and human colon cancer cells from HT-29 and RKO lines were separately incubated with glucose at concentrations of 1.25, 2.5 and 5 mg/ml and the capacity for production of TNFα, IL-1, IL-6, IFNγ, IL-1ra IL-10, and IL-2 was examined. In another set of experiments the effect of glucose on the secretion of these cytokines by PBMC co-incubated with carcinoma cells was evaluated.Results: Unstimulated PBMC incubated with glucose showed a slight to moderate inhibition of IFNγ and IL-10 secretion, whereas PBMC stimulated with LPS were not affected. Addition of glucose to PBMC stimulated by HT-29 colon carcinoma cells showed a slight spurring of TNFα production and a marked inhibition of IL-1, IFNγ and IL-10, an effect significantly less pronounced when glucose was added to co-cultures of PBMC with RKO cells.

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Section: Discussionsupporting

confidence: 80%

Glucose Modifies the Immune Interaction Between Mononuclear and Human Colon Carcinoma Cells

Djaldetti¹,

Bessler²

2017

Arch Microbiol Immunology

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“…Accordingly, Spindler et al . reported that PBMCs obtained from healthy subjects and induced with dextrose octreotide demonstrated reduced IL-6 and IL-17A expression, especially in CD14+ and CD16+ intermediate monocytes, indicating impaired immune responses due to high blood glucose levels [ 51 ]. Another study conducted by Price et al .…”

Section: Hyperglycemia and Susceptibility To Infectionmentioning

confidence: 99%

Type 2 Diabetes and its Impact on the Immune System

Berbudi

Rahmadika

Tjahjadi

et al. 2020

CDR

732

542

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Introduction:: Type 2 Diabetes (T2D) is a major health problem worldwide. This metabolic disease is indicated by high blood glucose levels due to insufficient insulin production by the pancreas. An inflammatory response occurs as a result of the immune response to high blood glucose levels as well as the presence of inflammatory mediators produced by adipocytes and macrophages in fat tissue. This low and chronic inflammation damages the pancreatic beta cells and leads to insufficient insulin production, which results in hyperglycemia. : Hyperglycemia in diabetes is thought to cause dysfunction of the immune response, which fails to control the spread of invading pathogens in diabetic subjects. Therefore, diabetic subjects are known to more susceptible to infections. The increased prevalence of T2D will increase the incidence of infectious diseases and related comorbidities. Objective: : This review provides an overview of the immunological aspect of T2D and the possible mechanisms that result in increased infections in diabetics. Conclusion: : A better understanding of how immune dysfunctions occur during hyperglycemia can lead to novel treatments and preventions for infectious diseases and T2D comorbidities, thus improving the outcome of infectious disease treatment in T2D patients.

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“…were exposed to high glucose levels [162] or dextrose octreotide. [163] This study demonstrates that glucose exposure dampened IL-2, IL-6 and IL-10 levels in a concentration-dependent manner while conversely inducing the expression of TGF-β1 which may explain immune failure. [162] Increased glycation leads to a reduction of IL-10 secretion by myeloid cells.…”

Section: Review Articlementioning

confidence: 67%

Untitled

2022

MEDICC Review

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Acute hyperglycemia impairs IL‐6 expression in humans

Cited by 19 publications

References 30 publications

Glucose Modifies the Immune Interaction Between Mononuclear and Human Colon Carcinoma Cells

Glucose Modifies the Immune Interaction Between Mononuclear and Human Colon Carcinoma Cells

Type 2 Diabetes and its Impact on the Immune System

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