Acute Infections in Atopic Dermatitis: A Clue for a Pathogenic Role of a Th1/Th2 Imbalance?

LaCour, Matthew

doi:10.1159/000247161

Cited by 22 publications

(16 citation statements)

References 10 publications

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“…Allergy is a state of immune dysregulation from Th1/Th2 balance and this state leads to overproduction of IgE (Lacour, 1994) which plays a central role in allergy (Jujo et al, 1992). Avoidance of allergen is the first principle for the treatment of allergic diseases (David, 1992).…”

Section: Introductionmentioning

confidence: 99%

Quantitative measurement of serum allergen-specific IgE on protein chip

Kim

Park²,

Cho³

et al. 2002

Exp Mol Med

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Type I allergy is an immunoglobulin E (IgE)-mediated hypersensitivity disease inflicting more than quarter of the world population. In order to identify allergen sources, skin provocation test and IgE serology was performed using allergen extracts. Such process identifies allergen-containing sources but cannot identify the disease-eliciting allergenic molecules. Recently, microarray technology has been developed for allergen-specific IgE detection using rolling circle amplification. This study was carried out to evaluate protein chip technology for the quantitative measurement and limits of sensitivity of multiple allergen-specific IgE by an immunofluorescence assay. Significance of positive calibrators was tested using purified human IgE. Dermatophagoides pteronyssinus (Dp), egg white, milk, soybean, and wheat were used as allergens and human serum albumin as negative control. Sensitivity and clinical efficacy of protein chip were evaluated using allergy immune serum for Dp. The fluorescent intensities for purified human IgE as calibrator were well correlated with the concentrations of human IgE. Twofold dilution of serum allowed an optimal reaction with Dp (1 mg/ml) at which serum Dp-specific IgE levels by protein chip were compatible with those by UniCap®. The sensitivity of protein chip in this study was found at level of 1 IU/ml of IgE. Dp-specific IgE levels by protein chip correlated well with those of UniCap® by comparing 10 atopic dermatitis. Additional 18 sera were tested for above multiple antigens other than Dp and significant results were obtained for many antigens as well as Dp. These results indicated that spotting of heterogeneous protein mixture on protein chip and the quantitative measurement of serum allergen-specific IgE levels using immunofluorescence assay can be successfully applied in the clinical laboratory for the diagnosis of allergy and could be applied to diagnosis of autoimmune and infectious diseases

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Section: Introductionmentioning

confidence: 99%

Quantitative measurement of serum allergen-specific IgE on protein chip

Kim

Park²,

Cho³

et al. 2002

Exp Mol Med

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“…Improvements in the severity of atopic dermatitis have been previously reported following natural VZV infection in subjects with atopic dermatitis [11,15], with available data indicating that this may be due to conversion of the CD4 T-cell profile from a Th2 to a Th1 phenotype [11]. It is possible that exposure to a live attenuated varicella vaccine could induce a similar phenotypic switch, which may have contributed at least in part to the improvements in the severity of atopic dermatitis seen following vaccination in this study.…”

Section: Discussionmentioning

confidence: 89%

Safety, reactogenicity, and immunogenicity of live attenuated varicella vaccine in children between 1 and 9 years of age with atopic dermatitis

Kreth

Hoeger

2006

Eur J Pediatr

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“…Asthma as an allergic disease develops early in life (13). Infections appear to afford a protection against the development of asthma and allergy (14), and children with eczema occasionally undergo temporary, spontaneous remission after severe bacterial and viral infections (15). Young adults who had experienced measles in childhood were significantly less likely to be atopic than those who had been vaccinated and/or had never had measles (16).…”

Section: Discussionmentioning

confidence: 99%

Impact of Circulating TGF-β and IL-10 on T Cell Cytokines in Patients with Asthma and Tuberculosis

et al. 2006

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Regulatory T cells, which stimulate or inhibit the effector functions of distinct T cell subsets, are critical in the control of the immune response. We investigated the effect of TGF-β and IL-10 on T cell subsets according to the Th1/Th2 immune status. Sixty-two patients with asthma and 38 patients with pulmonary tuberculosis were included. Allergy skin tests, tuberculin tests, and chest radiography were performed. The levels of circulating IL-4, IFN-γ, TGF-β1, and IL-10 were measured using ELISA. The level of TGF-β1 was higher in patients with asthma than in those with tuberculosis, but the IL-10 levels were the same between the asthma and tuberculosis groups. Atopy was unrelated to the tuberculin response. The IFN-γ level was correlated with the IL-10 level, and the level of IL-4 was unrelated to the IL-10 or TGF-β1 level. The level of IL-10 was higher in the negative tuberculin reactors than in the positive tuberculin reactors among patients with asthma, and TGF-β1 was higher in the positive tuberculin reactors than in the negative tuberculin reactors among patients with tuberculosis. These results demonstrate that the regulatory effects of circulating TGF-β and IL-10 on T cell cytokines may be different between Th2-type asthma and Th1 tuberculosis.

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Acute Infections in Atopic Dermatitis: A Clue for a Pathogenic Role of a Th1/Th2 Imbalance?

Abstract: Temporary improvement of atopic dermatitis lesions may occur after acute, severe infections. One such case is shortly described, and it is then proposed that such a phenomenon may serve as an indirect evidence to support the finding of a predominant Th2 imbalance in atopic dermatitis.

Cited by 22 publications

References 10 publications

Quantitative measurement of serum allergen-specific IgE on protein chip

Quantitative measurement of serum allergen-specific IgE on protein chip

Safety, reactogenicity, and immunogenicity of live attenuated varicella vaccine in children between 1 and 9 years of age with atopic dermatitis

Impact of Circulating TGF-β and IL-10 on T Cell Cytokines in Patients with Asthma and Tuberculosis

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