Acute phase response in the dog following surgical trauma

Conner, Joe; Eckersall, P.D.; Ferguson, Julie; Douglas, T. A.

doi:10.1016/s0034-5288(18)30902-0

Cited by 148 publications

(136 citation statements)

References 8 publications

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“…CRP is used as an indicator of inflammation in human medicine and clinically relevant cut-off points have been used routinely for various conditions 16,21,28 . This has not yet reached the same level of sophistication in veterinary medicine, although the relatively rapid production and clearance of CRP should make it a relevant indication of the clinical situation in an animal at any given time, or at least provide proof of the presence or otherwise of an inflammatory process 10,13 . The same should be true for any traumatic process.…”

Section: Discussionmentioning

confidence: 99%

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An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

Nevill¹,

Leisewitz²,

Goddard³

et al. 2010

J. S. Afr. Vet. Assoc.

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The extent of trauma in a patient can be difficult for a clinician to quantify. A prospective study was performed on 2 groups of dogs undergoing either ovariohysterectomy or hemilaminectomy. The serum activity of creatine kinase and serum concentration of C-reactive protein were evaluated preoperatively and then at 4, 6, 8, 12, 24 and 48 hours postoperatively in both groups. The results were compared statistically both within and between the 2 groups. A wide range of results was found at each time point for both analytes although there were no significant differences for either analyte between the 2 surgical groups preoperatively. Thereafter there were significant differences in creatine kinase activity levels between the 2 groups. C-reactive protein concentration results were very similar in the 2 groups with no statistical difference at any time point. The results of this study suggest that the evaluation of CK and CRP at any one time point in a traumatised animal is of limited value. However, the evaluation of the trend of these 2 analytes, even over a relatively short time period, may allow for useful prognostication in clinical cases

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Section: Discussionmentioning

confidence: 99%

“…These proteins are integral to the acute phase response, which is the body's rapid initial systemic inflammatory reaction to any non-specific tissue injury 10,13,24,29 . Examples of other acute phase proteins are fibrinogen, serum amyloid A, haptoglobin and ceruloplasmin.…”

Section: Introductionmentioning

confidence: 99%

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

Nevill¹,

Leisewitz²,

Goddard³

et al. 2010

J. S. Afr. Vet. Assoc.

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show abstract

“…Acute phase proteins (APPs) are proteins whose concentrations in serum change after an inflammatory stimulus (Conner and Eckersall, 1988). They are more sensitive markers of inflammation than traditional markers, such as fever, globular sedimentation rate, or leukocytes (Ramadori and Christ, 1999;Kogika et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Acute Phase Protein Response in the Capybara (Hydrochoerus Hydrochaeris)

Bernal

Feser

Martı́nez-Subiela

et al. 2011

Journal of Wildlife Diseases

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ABSTRACT:We evaluated the acute phase protein response in capybaras (Hydrochoerus hydrochaeris). Three animal groups were used: 1) healthy animals (n530), 2) a group in which experimental inflammation with turpentine was induced (n56), and 3) a group affected with sarcoptic scabies (n514) in which 10 animals were treated with ivermectin. Haptoglobin (Hp), acid-soluble glycoprotein (ASG) and albumin were analyzed in all animals. In those treated with turpentine, Hp reached its maximum value at 2 wk with a 2.7-fold increase, whereas ASG increased 1.75-fold and albumin decreased 0.87-fold 1 wk after the induction of inflammation. Capybaras affected with sarcoptic scabies presented increases in Hp and ASG of 4.98-and 3.18-fold, respectively, and a 0.87-fold decrease in albumin, compared with healthy animals. Haptoglobin and ASG can be considered as moderate, positive acute phase proteins in capybaras because they showed less than 10-fold increases after an inflammatory process and reached their peak concentrations 1 wk after the induction of inflammation. Conversely, albumin can be considered a negative acute phase protein in capybaras because it showed a reduction in concentration after inflammatory stimulus.

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“…CRP is a component of normal serum [7], which rises more dramatically than any other protein after surgical trauma [8][9][10]11]. CRP begins to rise 4-12 h post-operatively, reaches the peak level after 24-72 h, and returns to normal after 2 weeks [8,12,13,14]. Hence, this study was done to quantify the difference in tissue damage between open cholecystectomy (OC) and laparoscopic cholecystectomy (LC).…”

Section: Introductionmentioning

confidence: 99%

To Study the Levels of C - Reactive Protein and Total Leucocyte Count in Patients Operated of Open and Laparoscopic Cholecystectomy

Kohli

Bansal

Gupta

et al. 2014

JCDR

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Background: The recovery from laparoscopic cholecystectomy (LC) is rapid and most of the patients are discharged on the 1 st post-operative day. There is an increased concentration of certain serum proteins, known as acute-phase reactive proteins (APRP) during the post-operative period depends on the degree of tissue damage and the inflammatory reaction. There is a direct positive correlation between the concentrations of APRP, especially C-reactive protein (CRP), and the severity of inflammation. This study was done to study the levels of C -reactive protein and Total Leucocyte Count in patients operated either by Open Cholecystectomy (OC) and Laparoscopic Cholecystectomy (LC).

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Acute phase response in the dog following surgical trauma

Cited by 148 publications

References 8 publications

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

Acute Phase Protein Response in the Capybara (Hydrochoerus Hydrochaeris)

To Study the Levels of C - Reactive Protein and Total Leucocyte Count in Patients Operated of Open and Laparoscopic Cholecystectomy

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