Acute, Severe Cryptosporidiosis in an Immunocompetent Pediatric Patient

Tallant, Caitlin; Huddleston, Patrick; Alshanberi, Asim Muhammed; Misra, Subhasis

doi:10.4081/cp.2016.837

Cited by 12 publications

(14 citation statements)

References 16 publications

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“…It is often asymptomatic, mild or self-limiting in immunocompetent individuals and serious, even fatal in immunosuppressed individuals, such as HIV-infected persons [6,7]. A Cryptosporidium spp.…”

Section: Introductionmentioning

confidence: 99%

Review of Cryptosporidium and Giardia in the eastern part of Europe, 2016

et al. 2018

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IntroductionThis paper reviews the current knowledge and understanding of Cryptosporidium spp. and Giardia spp. in humans, animals and the environment in 10 countries in the eastern part of Europe: Bosnia and Herzegovina, Croatia, Czech Republic, Estonia, Hungary, Latvia, Poland, Romania, Serbia and Slovenia. Methods: Published scientific papers and conference proceedings from the international and local literature, official national health service reports, national databases and doctoral theses in local languages were reviewed to provide an extensive overview on the epidemiology, diagnostics and research on these pathogens, as well as analyse knowledge gaps and areas for further research. Results: Cryptosporidium spp. and Giardia spp. were found to be common in eastern Europe, but the results from different countries are difficult to compare because of variations in reporting practices and detection methodologies used. Conclusion: Upgrading and making the diagnosis/detection procedures more uniform is recommended throughout the region. Public health authorities should actively work towards increasing reporting and standardising reporting practices as these prerequisites for the reported data to be valid and therefore necessary for appropriate control plans.

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Section: Introductionmentioning

confidence: 99%

Review of Cryptosporidium and Giardia in the eastern part of Europe, 2016

et al. 2018

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“…infection as a clear signal of an increased risk of children contracting severe infectious diseases. 2,19 Likewise, we observed a significant increase in the number of cryptosporidiosis cases in children during the outbreak, the incidence of this infection was underestimated because of the difficulty to perform parasitological examination in remote area in all diarrhea cases. Because of the difficulty to promptly perform research in the context of an outbreak (particularly in remote areas) and of the retrospective nature of our study, we were unable to compare acute diarrhea cases due to cryptosporidiosis and other agents.…”

Section: Discussionmentioning

confidence: 83%

Cryptosporidiosis Outbreak in Immunocompetent Children from a Remote Area of French Guiana

Mosnier¹,

Martin²,

Razakandrainibe

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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In September 2014, an increase in the number of spp. gastrointestinal tract infections was reported over a 6-month period among children living in a remote area along the Maroni River in French Guiana. Children presented gastroenteritis symptoms with-positive stools. Questionnaires were administered and stool examinations were controlled 3 months after the onset of symptoms. Data collection included demographics, food consumption, river behavior, symptoms, and outcome. Stool specimens were tested using microscopy and polymerase chain reaction. Samples from the water systems were examined for turbidity and culture for bacteria. Data from the reference laboratory were analyzed to calculate the median cryptosporidiosis incidence among immunocompetent patients from 2008 to 2015. Data on gastroenteritis cases reported by the Delocalized Center for Prevention and Care in the area were also collected. We report a cluster of 14 cases. All cases were children, aged between 4.5 and 38 months. Seven reported moderate to severe dehydration and required hospitalization. Speciation and microbiological typing revealed the cluster strain was subtype IbA10G2 but IbA9G2 and IbA15G1 strains were also identified. The median incidence in French Guiana was 5.8 cases per year before the outbreak. The first cases of the cluster appeared in the dry season. We describe the clinical features, epidemiology, and state of current investigations for the largest documented outbreak of cryptosporidiosis in French Guiana.

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“…Protozoa of the genus Cryptosporidium are considered as one of the etiologic agents of persistent diarrheal illness in immunocompromised patients (Clemente et al 2000 ; Werneck-Silva and Bedin Prado 2009 ). However, they are more often detected also in HIV-negative humans, as a cause of travelers’ diarrhea, in immunocompetent children or in man infected with the hedgehog genotype (Kłudkowska et al 2017 ; Tallant et al 2016 ; Kváč et al 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Massive Cryptosporidium infections and chronic diarrhea in HIV-negative patients

et al. 2019

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Protozoa of the genus Cryptosporidium are common parasites of domestic and wild animals—mammals, birds, reptiles, and fishes. The invasive forms are thick-walled oocysts, which can be present in water supplies, on fruits, vegetables, or in the soil contaminated with feces. In this work, we describe three cases of middle-aged persons with massive Cryptosporidium hominis infection and chronic diarrhea with no immunological abnormalities and no history of previous travels to tropical countries. The lesions discovered during colonoscopy within the large intestine–cryptitis and the histopathological changes were related to massive cryptosporidiosis. All these statements indicate necessity of parasitological stool examination in cases with chronic diarrhea in which no etiological agents are detected, but not only in HIV positive individuals. Parasite’s eradication leads to symptom disappearance as well as improvement of histopathological mucosa alterations.

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Acute, Severe Cryptosporidiosis in an Immunocompetent Pediatric Patient

Cited by 12 publications

References 16 publications

Review of Cryptosporidium and Giardia in the eastern part of Europe, 2016

Review of Cryptosporidium and Giardia in the eastern part of Europe, 2016

Cryptosporidiosis Outbreak in Immunocompetent Children from a Remote Area of French Guiana

Massive Cryptosporidium infections and chronic diarrhea in HIV-negative patients

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