Acute, subacute toxicity and genotoxic effect of a hydroethanolic extract of the cashew (Anacardium occidentale L.)

Konan, Nzi André; Bacchi, Elfriede Marianne; Lincopán, Nilton; Varela, Soraya Duarte; Varanda, Eliana Aparecida

doi:10.1016/j.jep.2006.08.033

Cited by 74 publications

(61 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Otherwise, each test organism has peculiarities regarding the evaluation of toxic products with cytotoxic and antioxidants capabilities; although there is a good correlations of test eukaryotes to the mammals [42,43]. Thus the anacardic acid, cardanol and cardol may have cytotoxic activity also.…”

Section: Discussionmentioning

confidence: 99%

Net effects of cashew nuts in Saccharomyces cerevisiae front to damage induced by hydrogen peroxide

Leite¹,

Gomes²,

Oliveira³

et al. 2016

Int Arch Med

View full text Add to dashboard Cite

Cellular injury associated with oxidative stress has been related in the etiology and progression of many diseases, including neurodegenerative diseases and cancer. Shell of cashew nut releases the alkylphenols oil, known as cashew nut shell liquid (CNSL), which can be characterized according to the method of production such as technical (tCNSL) and in natural (iCNSL) types. This study aimed to characterize the chemical constituents in both liquids by gas chromatography coupled to mass spectrometry (GC-MS), and to evaluate the net effect of them in proficient (SODWT) and deficient (Sod1∆, Sod2∆, Cat1∆, Sod1∆Sod2∆, Sod1∆Cat1∆) Saccharomyces cerevisiae oxidative damaged induced by hydrogen peroxide (H 2 O 2 (10 mM); stressor) at concentrations of 17.37, 34.7 and 69.5 µg/ml in pre-, co-and post-treatment. Both iCNSL and tCNSL produced no oxidizing effect to the tested yeast strains, otherwise they protected against damage induced by stressor (STR). However, tCNSL was found more prominent than the iCNSL in restorative activity. In conclusion, CNSLs (iCNSL/tCNSL) exhibited excellent protective, antioxidant and repair capabilities compared to the damage induced by STR in S. cerevisiae cells, thus may be a suggestion for its biotechnological production especially for pharmaceutical account.

show abstract

Section: Discussionmentioning

confidence: 99%

Net effects of cashew nuts in Saccharomyces cerevisiae front to damage induced by hydrogen peroxide

Leite¹,

Gomes²,

Oliveira³

et al. 2016

Int Arch Med

View full text Add to dashboard Cite

show abstract

“…A total of 24 male and female Wistar rats of 2 months age (male, 130-150 g; female, 150-170 g) were used for the toxicological studies. The animals were acclimatized to the laboratory conditions (approximately 25 °C, 55% humidity, 12-h day/night cycle) for a week prior to the experiments [86]. During acclimatization, the cages were properly disinfected and two to three rats were kept in each polycarbonate cage and fed with normal diet and water.…”

Section: Sub-acute Toxicity Study Of Tomatoes Grown With Bbrdmmentioning

confidence: 99%

“…Organs were fixed in a 10% solution of buffered formalin, having pH 7.4 and enclosed in paraffin. Five-micrometer tissue sections were colored with hematoxylin-eosin and observed microscopically [85,86].…”

Section: Sub-acute Toxicity Study Of Tomatoes Grown With Bbrdmmentioning

confidence: 99%

Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

et al. 2015

View full text Add to dashboard Cite

Environmental and health safety of recycled slaughterhouse wastes-derived fertilizer and the produce obtained through its application is not well understood. Waste bovine blood and rumen digesta were mixed, cooked and sun-dried to obtain bovine-blood-and-rumen-digesta-mixture (BBRDM, NPK 30.36:1:5.75). 1.26 ± 0.18 log CFU mL −1 fecal coliforms were recovered in BBRDM. E. coli O157:H7, Mycobacteria, Clostridium sp., Salmonella sp., Bacillus sp. and Brucella sp. were absent. No re-growth of pathogens was observed after 60 days storage in sealed bags and in the open. However, prions and viruses were not evaluated. Heavy metals (Pb, Cr, Cd, Cu, Zn, As, Ni, Mn) concentrations in BBRDM were within internationally permissible limits. BBRDM was applied for field cultivation of tomato during 2012-2013 and 2013-2014. Lycopene and nitrate contents of BBRDM-grown tomatoes were higher than Diammonium OPEN ACCESSAgriculture 2015, 5 827 phosphate (DAP) + potash-grown tomatoes because BBRDM supplied 2.5 times more the amount of nitrogen than DAP (NPK 18:46:0) + potash (NPK 0:0:44). Heavy metals and nitrate/nitrite concentrations in tomatoes were within internationally acceptable limits. BBRDM-grown tomatoes showed no mutagenic activity in the Ames test. Sub-acute toxicity tests on Wistar rats fed with BBRDM-grown tomatoes did not show adverse clinical picture. Thus, no immediate environmental or health risks associated with BBRDM and the tomatoes produced were identified.

show abstract

“…For example, Ayoka et al (2006) evaluated extracts of Spondias mombin L., and Konan et al (2007) assessed a hydroalcoholic extract of Anacardium occidentale L. and observed the absence of toxic symptoms or the death of animals. It is suggested that further tests should be performed to confirm the toxicological profile of the plant…”

Section: Acute Toxicitymentioning

confidence: 99%

Evaluation of the potential modulator of bacterial resistance, acute toxicity and chemical composition of Schinopsis brasiliensis Engl.

Thiago¹,

Alinne²,

Nunes³

et al. 2015

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

In Brazil's semi arid region, Schinopsis brasiliensis Engl. (Anacardiaceae) is used in traditional medicine, but little is known about its chemical, pharmacological and toxicological properties. In this study, the phytochemical and biological potential of the extract of S. brasiliensis (EESb) was evaluated. The main secondary metabolites in EESb were quantified by spectroscopy in the visible region. The minimum inhibitory concentration (MIC) of the extract, of antibiotics alone and of antibiotics combined with the extract were determined using microdilution method, and the acute toxicity was determined by in vivo tests. In microbiological testing, the EESb showed good antimicrobial activity against Staphylococcus aureus and, when combined with synthetic antibiotics, potentiated its activity by reducing the MIC values. In vivo studies showed low acute toxicity in rats treated with EESb. These results demonstrate the richness of the phenolic compounds in S. brasiliensis and its effectiveness as an antibacterial and in modulating activities of bacterial resistance. The probable low toxicity was also demonstrated.

show abstract

Acute, subacute toxicity and genotoxic effect of a hydroethanolic extract of the cashew (Anacardium occidentale L.)

Cited by 74 publications

References 23 publications

Net effects of cashew nuts in Saccharomyces cerevisiae front to damage induced by hydrogen peroxide

Net effects of cashew nuts in Saccharomyces cerevisiae front to damage induced by hydrogen peroxide

Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

Evaluation of the potential modulator of bacterial resistance, acute toxicity and chemical composition of Schinopsis brasiliensis Engl.

Contact Info

Product

Resources

About