Acute systemic response to intraperitoneal implantation of polypropylene mesh/chitosan-based film composite in pigs

Abstract

PURPOSE:To assess the systemic response of pigs to the intraperitoneal implantation of polypropylene mesh associated with chitosanbased film with a degree of deacetylation of 95%. METHODS:Blood samples were collected 24 hours before, and two and seven days after surgery. Systemic reactions were evaluated based on white blood cell count, C-reactive protein, and total serum protein, albumin and globulin levels. RESULTS:The systemic response was proportional to the composite response induced by polypropylene mesh, and the tissue inflammatory response was higher in the PP group (p=0.0033). CONCLUSION:The polypropylene mesh/chitosan-based film composite did not elicit a systemic response in pigs.

Hemogram dan Respon Jaringan Hernia Insisional Babi Pascaterapi Mesh Bedah Polipropilen dengan atau tanpa Asam Hyaluronat

“…Penurunan nilai hemogram pada total WBC dan diferensial leukosit mengindikasikan sel darah putih tersebut telah berpindah dari sirkulasi menuju ke jaringan sebagai bentuk respon tubuh terhadap adanya benda asing (Martins et al, 2015). Penggunaan mesh bedah ringan polipropilen menginduksi reaksi inflamasi dan memicu persembuhan yang cepat (Melman et al, 2011).…”

“…Monosit adalah sel darah putih yang terlibat dalam sistem monosit-makrofag, akan bermigrasi menuju lokasi peradangan dan berdiferensiasi menjadi makrofag (McGavin & Zachary, 2007). Sistem monosit-makrofag pada reaksi peradangan akut, sangat berperan penting dalam persembuhan jaringan (Martins et al, 2015).…”