Acute toxicity studies of polyherbal formulation Methiorep Premix

Rajurker, S; Rekhe, Rekhe; DS, DS; Maini, Maini; S, S; Ravikanth, Ravikanth; K, K

doi:10.5455/vetworld.2009.58-59

Cited by 14 publications

(12 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drugs and plant products are usually subjected to toxicity tests with experimental animals in order to predict safety or toxicity, and to provide guidelines for selecting safe doses in humans. Signs of toxicity include convulsions, tremors, protrusion of eye ball, and mortality (Rajurker et al, 2009). However, as no such signs were observed, the result of this present study, therefore, indicated no toxicity of the methanolic S. macrocarpon fruit extract.…”

Section: Discussioncontrasting

confidence: 48%

Phytochemistry, acute toxicity and blood profile of albino rats treated with fruit extract of Solanum macrocarpon

Mbegbu¹,

Ezechukwu²,

Chikwendu³

et al. 2019

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

Phytochemical screening of the methanolic fruit extract of Solanum macrocarpon was performed using standard method. Eighteen male albino mice, assigned into six groups (n=3) were used to determine the acute toxicity (LD 50) of the extract. Haematological effect of the extract was determined using forty eight adult male rats assigned into four groups (A-D; n=12). The treatment groups received daily oral administration of the extract at doses of 400, 800 and 1600 mg/kg of body weight (bw) respectively for 21 days. The phytochemical screening of the extract revealed the presence of flavonoids, saponins, alkaloids, phenols, phytates, tannins, cyanides and terpenoids. The extract showed no mortality even at the dose of 5000 mg/kg bw. The highest treatment dose (1600 mg/kg) showed significant reduction in the white blood cell (WBC) count compared to rest of the treatment groups. There were no significant difference (p<0.05) in red blood cell (RBC), packed cell volume (PCV) and haemoglobin (Hb) levels of the treatment groups compared to control. Similarly, the mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) results showed no significant difference from days 0 to 21 in all the treatment groups. Findings from this study suggest that except for the fact that the high dose of the extract antagonizes immunity; it has no serious adverse effect on the various haematological parameters, especially as it improves haemoglobin levels on prolonged administration.

show abstract

Section: Discussioncontrasting

confidence: 48%

Phytochemistry, acute toxicity and blood profile of albino rats treated with fruit extract of Solanum macrocarpon

Mbegbu¹,

Ezechukwu²,

Chikwendu³

et al. 2019

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

show abstract

“…This demonstrates the safety of natural methionine as well as synthetic methionine for broilers. This finding is in agreement with those of previous workers who did not observe any detrimental effects from herbal methionine supplementation …”

Section: Resultssupporting

confidence: 94%

“…This finding is in agreement with those of previous workers who did not observe any detrimental effects from herbal methionine supplementation. 16,25,26…”

Section: Resultsmentioning

confidence: 99%

Evaluation of a natural methionine source on broiler growth performance

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The implication is that dietary herbal methionine has no detrimental effect on survivability of chickens. Rajurker et al (2009) also reported that herbal methio-nine supplement (Methiorep®) is totally safe and has no adverse effect even when used at the highest limit dose of 5 g/kg body weight of male Wistar rats. Total plasma protein, albumin, and globulin concentrations observed are within the normal range reported for chickens (Prabhakaran et al, 1996).…”

Section: Sourcementioning

confidence: 99%

Performance characteristics, biochemical and haematologcal profiles of broiler chickens fed synthetic and herbal methionine supplemented diets

Igbasan¹

2013

Afr. J. Food Sci.

View full text Add to dashboard Cite

This study was conducted to compare the efficacy of herbal methionine (HM) to synthetic methionine (SM) in broiler chickens. The herbal methionine (Meth-o-Tasr®) was supplied by lntas Pharmaceutical Limited, India. The HM and SM were added to standard diets at 0, 0.5, 1.0 and 1.5 kg/ton of finished feed and fed to 168 Arbor Acre broiler chickens. After seven days pre-experimental period, the birds were randomly allocated to seven isonitrogenous and isocaloric dietary treatments in a completely randomized experimental design with factorial arrangement of treatments. Each treatment was replicated four times with six birds per replicate. The trial lasted for 56 days and was divided into two phases; the starter phase and the finisher phase. The final body weight, body weight gain, feed intake and feed conversion ratio (FCR) of the birds were determined on a weekly basis. At the end of the feeding trial, two birds per replicate were randomly selected and slaughtered for the determination of carcass quality traits and biochemical and haematological profiles. The average final body weight, body weight gain and average feed intake of the birds fed on diets supplemented with SM were significantly different (P ≤ 0.05) from those fed on diets supplemented with HM at both starter and finisher phases. The birds on SM supplemented diets gained more body weight and consumed more feed than those on HM supplemented diets. Feed conversion efficiency was not affected (P ≥ 0.05) by the dietary methionine source. Birds on SM supplemented diets had better (P ≤ 0.05) carcass yield than those on HM and control diets. Dietary HM supplementation did no significant (P ≥ 0.05) effect on any of the biochemical or haematological variables determined. It can be concluded from this study that, though no detrimental health effects, were detected, dietary HM is not an effective substitute for synthetic methionine for optimum production performance.

show abstract

Acute toxicity studies of polyherbal formulation Methiorep Premix

Cited by 14 publications

References 1 publication

Phytochemistry, acute toxicity and blood profile of albino rats treated with fruit extract of Solanum macrocarpon

Phytochemistry, acute toxicity and blood profile of albino rats treated with fruit extract of Solanum macrocarpon

Evaluation of a natural methionine source on broiler growth performance

Performance characteristics, biochemical and haematologcal profiles of broiler chickens fed synthetic and herbal methionine supplemented diets

Contact Info

Product

Resources

About