Acute Toxicity Study of “Gadagi” Tea on Rats

Gadanya, Aisha Muhammad; Sule,; Atiku, M. K.

doi:10.4314/bajopas.v4i2.29

Cited by 9 publications

(7 citation statements)

References 3 publications

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“…In this experiment the ethanol extract of PFF contained saponins, tannins and flavonoids on acute toxicity test and did not case the death of the animals. This results reported by Kalu et al [13] who stated that leaf extract of Combretum dolichopentalum contain saponins, alkaloids, flavonoids also did not find any dead mice.The same result was also reported by Gadanya et al [8].…”

Section: B Acute Toxicity Ethanol Extract Of Pffsupporting

confidence: 90%

Phytochemical and acute toxicity studies of ethanol extract from Pedada (Sonneratia caseolaris) fruit flour (PFF)

Jariyah¹,

Widjanarko²,

Yunianta³

et al. 2015

International Journal on Advanced Science, Engineering and Information Technology

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Studies on the phytochemical and acute toxicity of pedada fruit flour (PFF) were carried out. In acute toxicity test, oral administration of the extract to Swiss albino mice at four levels dose, i.e. 0, 10.50; 15.75 and 21.00 g/kg body weight. Phytochemical analysis of the ethanol extract of PFF showed the presence of saponins, sapogenins, terpenoids, flavonoids, tannins, polyphenols. Phytochemicals such as alkaloids were not detected. The results of acute toxicity (LD50) showed that the ethanol extract of PFF in mice was found more than 21.00 g/kg body weight. It could be concluded that the PFF belongs to relatively less dangerous category 'non-toxic' and 'safe' for food products.

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Section: B Acute Toxicity Ethanol Extract Of Pffsupporting

confidence: 90%

Phytochemical and acute toxicity studies of ethanol extract from Pedada (Sonneratia caseolaris) fruit flour (PFF)

Jariyah¹,

Widjanarko²,

Yunianta³

et al. 2015

International Journal on Advanced Science, Engineering and Information Technology

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“…The fact that no macroscopic pathological changes were observed in all the liver organs extracted and no significant difference (p>0.05) in the percentage change in weight and relative liver weights among all experimental groups was recorded suggests the non-toxicity of the extract. It is known that the lower the LD 50 , the more toxic the extract is and the higher the LD 50 value, the lower the toxicity of the tested extract (Gadanya et al 2011). Thus, the ethanolic leaf extract of Irvingia gabonensis (O'Rorke) baill is considered safe as extracts or chemicals with LD 50 beyond 5000mg/kg body weight are considered safe (Lorke 1983).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical composition, in vitro antioxidant activity and acute toxicity of Irvingia gabonensis (Oâ€™Rorke) baill ethanolic leaf extract

Ewere¹,

Uka²,

Usunobun³

2016

IJBR

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This study was aimed at determining the phytochemical composition, antioxidant effect and acute toxicity of Irvingia gabonensis (O'Rorke) baill (IG) ethanolic leaf extract. Qualitative phytochemcal analysis was carried out on the ethanolic leaf extract using standard procedures. Different concentrations of the plant extract (20 µg/ml-100µg/ml) were used to assess its effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical activity, It's reducing power and it total phenolic content. Lorke's method of acute toxicity was adopted for the acute toxicity study. Results obtained showed the presence of saponins, tannins, flavonoids, cardiac glycosides, steroids, and carbohydrates in the leaf extract. The ethanolic leaf extract of IG significantly (P< 0.05) inhibited the activity of DPPH when compared with the vitamin C standard. IG leaf extract also showed a higher reducing power as compared with the Vitamin C standard. The total phenolic content of IG ethanolic leaf extract was however, significantly (P<0.05) lower than that of gallic acid, the standard used. Futhermore, the LD50 of the ethanolic leaf extract was found to be above 5000mg/kg body weight. Irvingia gabonensis (O'Rorke) baill ethanolic leaf extract is a rich source of important phytochemicals and possesses a high antioxidant activity. Also, the administration of the ethanolic leaf extract in wistar rats is safe up to a dose of 5000mg/kg body weight.

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“…Furthermore, the non-significant difference in the RBC and haemoglobin concentration in all the groups indicates that the extracts may not induce anaemia in animals, thus making it safe. In the same way, results do not show any haematopoietic ability for the extracts, as there was no observation of increase in the red blood cells of the animals (Gadanya et al, 2011). No significant differences were observed in creatinine and urea concentration in the serum of all the treated rats and the control, suggesting no kidney damaging effect (Patrick-Iwuanyanwu et al, 2012).…”

Section: Sub-acute Toxicity Profilementioning

confidence: 85%

Acute and Sub-Acute Toxicity of Cola millenii Leaf and Stem Bark Extracts in Albino Rats

Adewumi¹,

Akinnibosun²

2019

Not Sci Biol

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In the present study, the toxicity of monkey kola (Cola millenii) leaf and stem bark extracts were investigated in laboratory animals. The rats were orally administered with the plant extracts at gradual doses of 10 mg/kg, 100 mg/kg, 1,000 mg/kg, 2,500 mg/kg, 3,500 mg/kg and 5,000 mg/kg b.w. and were closely monitored for 24 h. In sub-acute toxicity, the animals were given 1,000 mg/kg b.w. and 2,500 mg/kg b.w. for 28 days. Thereafter, the effect of the extracts on the weight and haematological parameters of the rats were determined. The rats did not show any symptoms of toxicity throughout the experiment. In the sub-acute toxicity assay, starting from week two, the groups administered with 1,000 mg/kg and 2,500 mg/kg stem bark extract had significant (p ≤ 0.05) lower weight compared with the other groups. In the haematological assay, there were no significant differences (p ≥ 0.05) between the RBC and platelet counts as well as PCV, haemoglobin, urea, cholesterol, creatinine, LDL, HDL and AST level of all the groups given the extract in comparison with the control. Albeit, the level of white blood cells count, was higher in the treated groups compared with the control with concomitant significant (p ≤ 0.05) increase in the ALT and ALP levels of the animals treated with the extracts compared with the control. Results show that Cola millenii leaf and stem bark extracts are safe for oral use, although, at higher doses, stem bark extract may cause liver damage.

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Acute Toxicity Study of “Gadagi” Tea on Rats

Cited by 9 publications

References 3 publications

Phytochemical and acute toxicity studies of ethanol extract from Pedada (Sonneratia caseolaris) fruit flour (PFF)

Phytochemical and acute toxicity studies of ethanol extract from Pedada (Sonneratia caseolaris) fruit flour (PFF)

Phytochemical composition, in vitro antioxidant activity and acute toxicity of Irvingia gabonensis (Oâ€™Rorke) baill ethanolic leaf extract

Acute and Sub-Acute Toxicity of Cola millenii Leaf and Stem Bark Extracts in Albino Rats

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