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Acute toxicity study was carried out on three most common types of "Gadagi" tea preparations, "sak'',"sada" and "magani".. LD 50 values of each type of the tea were determined. Results of phase I and phase II of the study showed no mortality was recorded in any of the experimental groups of rats in 24hours and up to four weeks after oral administration of 5000mg/kg of each type of the tea. Hence, oral administration of all the "Gadagi" tea preparations studied at a dose of less than or equal to 5000mg/kg (equivalent to 7.90cm 3 , 6.90cm 3 and 8.20cm 3 for "sak", "sada" and "magani" respectively) could be safe.

In order to assess the potency of aqueous stem bark extract of Khaya senegalensis (KS) against liver diseases, serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were assayed in rats treated with two (2) different doses of the extract after the induction of liver damage in the rats using carbon tetrachloride, CCl 4. The rats treated with a daily dose of 80mg/kg for six (6) days had serum liver enzymes activities not significantly different from those in control rats; whereas those treated with a daily dose of 200mg/kg for nine (9) days had serum liver enzymes activities significantly higher (P<0.05) than those in control rats. Thus, a dose of 80mg/kg aqueous bark extract of KS for 6 days could be potent against liver disease, but a higher dose of 200mg/kg for 9 days could induce liver toxicity.

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