Acute treatment with 5-HT3 receptor antagonist, tropisetron, reduces immobility in intact female rats exposed to the forced swim test

Bravo, Gabriela; Maswood, Sharmin

doi:10.1016/j.pbb.2006.09.003

Cited by 44 publications

(35 citation statements)

References 52 publications

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“…Some publications suggest that 5-HT3 receptor antagonists might enhance physical activity in rats. 23,24 However, the findings derive from particular models that are not easily comparable with our experimental setting. Moreover, these studies did not address body weight changes.…”

Section: Discussionmentioning

confidence: 69%

Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice

et al. 2009

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Objective: Sugar consumption has increased markedly over the last few decades and parallels the dramatic increase in overweight and obesity. Data obtained from animal studies suggest that the intestinal serotonergic system and herein particularly the serotonin receptor 3 (5-HT3R) may be involved in sugar detection and short-term control of food intake. Using a mouse model, we tested the hypothesis that blocking 5-HT3R prevents the development of sugar-induced obesity. Design: For 8 weeks, C57BL/J6 mice were offered either water containing 30% glucose or plain water in addition to normal chow. The effect of oral treatment with the 5-HT3R antagonist, tropisetron (0.2 mg kg À1 body weight), on body weight and caloric intake was studied. Results: Total caloric intake and weight gain were significantly increased in mice fed glucose compared with the control group. Tropisetron treatment reduced intestinal motility and almost completely blocked weight gain associated with glucose feeding; however, total caloric intake was not affected. The effect of tropisetron was not associated with a decreased expression of the intestinal and hepatic glucose transporters, SGLT1 (sodium-dependent glucose cotransporter) and Glut2 (glucose transporter 2); instead, the expression of these transporters was slightly increased by the 5-HT3R antagonist. However, expressions of carbohydrate responsive element binding protein and fatty acid synthase, as well as triglyceride levels in the liver were only enhanced in mice fed glucose, but remained unchanged at the level of the control group when mice were treated concomitantly with tropisetron. At the same time, b-hydroxybutyrate dehydrogenase mRNA expression and plasma levels of ketone bodies were significantly increased. Conclusion: Our results suggest that 5-HT3R is a new target for the modulation of hepatic glucose metabolism and for the prevention of obesity.

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Section: Discussionmentioning

confidence: 69%

Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice

et al. 2009

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“…6C). Imipramine injection slightly, but significantly reduced the general locomotor acitivity already after the first (Time: F (16,352) F (9,198) =6.47, p<0.01; Treatment x Time interaction: F (9,198) =4.45, p<0.01).…”

Section: Experiments 4: Imipraminementioning

confidence: 91%

“…Injection of saline into the peritoneal cavity enhanced the heart rate both after the first (Time: F (16,128) =6.62, p<0.01) and second occasion (Time: F (7,70) =11.15, p<0.01) lasting approx. 30 min (Fig.…”

Section: Experiments 4: Imipraminementioning

confidence: 97%

“…Struggling is defined as vigorous movements of the four limbs, with the front paws breaking through the surface of the water, against the wall of the tank [15]. During swimming rats made coordinated and sustained movements with all four limbs, usually traveling around the interior of the cylinder, but without breaking the surface of the water with forelimbs [16]. During diving, the rats submerge entire head and body beneath the water [17].…”

Section: Forced Swim Testmentioning

confidence: 99%

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Do stress hormones connect environmental effects with behavior in the forced swim test?

et al. 2011

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“…Climbing/struggling was defined as vigorous movements of the four limbs, with the fore paws breaking through the water's surface, along the wall of the tank (Wongwitdecha et al, 2006). Swimming differs from climbing that the rats make coordinated and sustained movements with all four limbs, usually traveling around the interior of the cylinder, but did not break the surface of the water (Bravo and Maswood, 2006). During diving the rats submerged entire head and body beneath the water surface (Arunrut et al, 2009, Pinter et al, 2011.…”

Section: Forced Swimmingmentioning

confidence: 99%

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Balázsfi

Pintér

Klausz

et al. 2015

Psychoneuroendocrinology

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Short title:Stress-related behavior in Brattleboro rat after DDAVP treatment You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com) Balázsfi et al. 2Highlights  The effect of AVP on affective and memory symptoms is due to its central role  DDAVP treatment compensated the peripheral effects of congenital AVP absence  DDAVP did not significantly alter the behavior of KO animals in the paradigms tested  AVP signaling in the medial amygdala contributes to the behavioral effect measured in FS AbstractBeside its hormonal function in salt and water homeostasis, vasopressin -released into distinct brain areas -plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state.We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP also corrects the behavioral alterations in AVP-deficient Brattleboro rats. Wild type (WT) and vasopressin-deficient (KO) male Brattleboro rats were tested.Half of the KO animals were treated by desmopressin (V2-receptor agonist) via osmotic minipump (subcutaneous) to eliminate the peripheral symptoms of vasopressin-deficiency. Anxiety was studied by elevated plus maze (EPM), defensive withdrawal (DW) and marble burying (MB) tests, while depressive-like changes were monitored in forced swimming (FS) and anhedonia by sucrose preference test. Cell activity was examined in septum and amygdala by c-Fos immunohistochemistry after 10min FS.

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Acute treatment with 5-HT3 receptor antagonist, tropisetron, reduces immobility in intact female rats exposed to the forced swim test

Cited by 44 publications

References 52 publications

Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice

Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice

Do stress hormones connect environmental effects with behavior in the forced swim test?

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

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