Acute Uveitis following COVID-19 Vaccination

ElSheikh, Reem H; Haseeb, Abid; Eleiwa, Taher; Elhusseiny, Abdelrahman M.

doi:10.1080/09273948.2021.1962917

Cited by 73 publications

(48 citation statements)

References 10 publications

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“…In the study of Naharci et al, an 88-year-old female patient developed blurred vision and delirium one day after the CoronaVac vaccine [20] . In the study of Leber et al, bilateral optic neuritis was found after vaccination in a patient who had CoronaVac vaccine [21] .In another study, anterior uveitis was found in 2 eyes of a patient 5 days after receiving the inactivated coronavirus vaccine [22] .…”

Section: Discussionmentioning

confidence: 94%

The assesment of retina and optic disc vascular structures in people who received CoronaVac vaccine

Gedık¹,

Bozdoğan²,

Yavuz³

et al. 2022

Photodiagnosis and Photodynamic Therapy

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Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that is responsible for the current coronavirus disease pandemic and the vaccines currently developed are administered to prevent this infection. CoronaVac is a vaccine produced by the inactivated virus method. Ocular side effects such as anterior uveitis, optic neuritis, vision loss, episcleritis, allergic reaction and paracentral acute middle maculopathy have been reported after receiving CoronaVac vaccine. We assume that with this study, we can identify potential changes in posterior segment structures and posterior segment vascular density of people who received CoronaVac vaccine with optical coherence tomography angiography (OCTA) device. Material Method Forty healthcare professionals who applied to the Health Sciences University Antalya Training and Research Hospital Ophthalmology Clinic for routine eye control were included in the study. The subjects who do not have any systemic condition and would be administered CoronaVac vaccine were chosen to assess. OCTA images of the patients before and within 1 week after vaccination were captured, then retinal and optic disc vascular values, foveal avascular zone (FAZ), choriocapillary blood flow (CBF), subfoveal choroidal thickness (SCT) and retinal thickness were analyzed and compared. Results Two of the 40 patients had burning and stinging in the eye (5%), two of the 40 patients had redness (5%) and itching (5%) in the eye. 36 patients did not have any ocular symptoms.No statistically significant difference was found in the retinal and optic disc vascular density values, FAZ, CBF, SCT and retinal thickness values of the patients before and after vaccination. Conclusion This is the first research in the literature to evaluate the changes in retinal and optic disc vascular values in the people who received CoronaVac vaccine. In this study, we observed that CoronaVac vaccine did not affect retinal and optic disc vascular density significantly.

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Section: Discussionmentioning

confidence: 94%

The assesment of retina and optic disc vascular structures in people who received CoronaVac vaccine

Gedık¹,

Bozdoğan²,

Yavuz³

et al. 2022

Photodiagnosis and Photodynamic Therapy

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“…The proposed mechanisms of action include molecular mimicry, delayed hypersensitivity, or other immune responses. [112][113][114] In a multi-center study of 23 eyes of 21 patients that developed an acute episode of uveitis after the BNT162b2 vaccine (Pfizer), 8 patients (38%) had a known history of uveitis, the median time to onset was approximately 8 days, and most patients (86%) had mild to moderate anterior uveitis that significantly improved with topical therapy or intravitreal steroids. 115 The authors suggested that the vaccine may have triggered a type I interferon secretion, leading to an autoimmune reaction.…”

Section: Potential Systemic and Ocular Side Effectsmentioning

confidence: 99%

Ocular and Systemic Complications of COVID-19: Impact on Patients and Healthcare

Leung¹,

Fan²,

Flynn³

et al. 2022

OPTH

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There is increasing information available about the effects of the SARS-CoV-2 virus on the systemic and ocular health of patients, as well as the effects of delayed health care. This mini-review summarizes the potential complications and treatments of COVID-19. Systemic findings include respiratory illness, risk of thromboembolic events, and neurologic findings. Some patients may develop persistent symptoms even after the infection resolves. Effective treatment options include glucocorticoids, antivirals, interleukin-6 antagonists, monoclonal antibodies, Janus kinase inhibitors and vaccines. Potential ocular findings of COVID-19 include conjunctivitis, cranial nerve palsies, and microvascular changes in the retina; most symptoms resolved over time. During the lockdown periods, teleophthalmology was utilized to triage non-urgent issues; patients who did present to emergency departments tended to have more severe disease with worse visual prognoses. While transient delays in outpatient ophthalmic care may be tolerated in some patients, others experienced significant vision loss with interruptions in treatments. Resumption of ophthalmic care as soon as possible may help mitigate the effects of delayed care due to the pandemic.

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“…Ocular adverse events present after COVID-19 vaccination have been reported, among which corneal transplant rejection is the most common [6,7]. Others include uveitis and retinal abnormalities [8][9][10]. Here, we reported two cases of herpetic keratitis that occurred soon after COVID-19 immunization, but whether the herpetic keratitis is a real adverse reaction or a coincidental event is not established definitively.…”

Section: Introductionmentioning

confidence: 85%

Herpetic Keratitis Preceded by COVID-19 Vaccination

Jia

et al. 2021

Vaccines

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The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after receiving the inactivated COVID-19 vaccines. Case 1 was a 60-year-old woman who underwent penetrating keratoplasty (PKP) one year ago for corneal scarring caused by herpes simplex keratitis (HSK), and case 2 was a 51-year-old man with an unremarkable medical history. Both patients developed herpetic keratitis (HSK and varicella-zoster virus corneal endotheliitis, respectively) soon after receiving the inactivated COVID-19 vaccines (Sinovac). Herpetic keratitis was treated successfully with topical or plus oral antiviral ganciclovir. The short latency time in these two cases suggested that an inactivated COVID-19 vaccine may have a risk of triggering ocular herpes virus reactivation. Both clinicians and patients should be aware of this phenomenon. However, a causal relationship awaits confirmation.

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Acute Uveitis following COVID-19 Vaccination

Cited by 73 publications

References 10 publications

The assesment of retina and optic disc vascular structures in people who received CoronaVac vaccine

The assesment of retina and optic disc vascular structures in people who received CoronaVac vaccine

Ocular and Systemic Complications of COVID-19: Impact on Patients and Healthcare

Herpetic Keratitis Preceded by COVID-19 Vaccination

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