Acylamino acid chiral fungicides on toxiciepigenetics in lambda DNA methylation

Yin, Jing; Zhu, Feilong; Wang, Hao; Xu, Qi; Chang, Jin Soo; Wang, Huili; Guo, Baoyuan

doi:10.1016/j.fct.2017.04.038

Cited by 4 publications

(1 citation statement)

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“…The effect of pesticides on the duration of various phases of mitosis may be due to the epigenetic activity of pesticides. It has been demonstrated, that pesticides can affect the activity of methylases and rearrange gene expression patterns [9,50]. It could be possible, that epigenetic rearrangements, induced by pesticides, lead to alterationsof proliferative signaling and to a change in the activity of molecular events in different phases of mitosis.…”

Section: Discussionmentioning

confidence: 99%

Cytological Effects of Herbicidal and Fungicidal Pesticides on Root Apex Meristem Cells of Triticum Aestivum

Menzyanova

Shishatskaya

Pyatina

et al. 2020

Preprint

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Using the example of 2-day-old Triticum aestivum seedlings, grown in hydroponic culture, the cytological effects of pesticides with various mechanisms of the damaging were studied: the herbicides metribuzin, tribenuron-methyl, fenoxaprop-P-ethyl and the fungicides tebuconazole, epoxiconazole, and azoxystrobin. All pesticides showed a dose-dependent inhibitory effect on the development of the roots of Triticum aestivum, but did not affect the mitotic activity and did not reduce the mitotic index of root apex meristem cells. Herbicides and fungicides affected the duration of metaphase, anophase, prophase, and cytokinesis activity in the root apex meristem of the wheat, and these changes were specific for the six studied preparations. Under the influence of all pesticides, the number of abnormal cells increased significantly, to the greatest extent (10–12 times compared with control - distilled water) under the influence of herbicides tribenuron-methyl and phenoxaprop-ethyl and fungicides azoxystrobin and epoxiconazole; to a lesser extent - under the influence of metribuzin and tebuconazole (6–7 times). For all studied pesticides the manifestation of cyto- and genotoxicity, including both clastogenic and aneugenic effects, was revealed in relation to the non-target plant Triticum aestivum. Under the influence of pesticides, structural anomalies, caused by chromosome breakdown (bridges, fragments, micronuclei) and spindle damage (lagging chromosomes and their fragments, uneven chromosome separation) were detected in the cells of the Triticum aestivum root apex meristem.

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Section: Discussionmentioning

confidence: 99%