Acylated flavonol tri- and tetraglycosides in the flavonoid metabolome of Cladrastis kentukea (Leguminosae)

Kite, Geoffrey C.; Rowe, Emily R.; Lewis, Gwilym P.; Veitch, Nigel C.

doi:10.1016/j.phytochem.2010.12.017

Cited by 22 publications

(27 citation statements)

References 11 publications

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“…The results obtained from MS and HPLC characterization of the oolong tea are in excellent agreement with findings reported by others [18–20], demonstrating the complexity and variety of components present in tea. A detailed study on 41 green teas and 25 fermented teas enabled Lin et al to classify the teas into five categories based upon their compounds [18].…”

Section: Resultssupporting

confidence: 90%

“…The flavonoids identified in the tea sample are given in Appendix Tables 1 and 2 for results obtained in the negative and positive ion modes, respectively. For structural assignment the observed full mass and MS/MS were compared to those of known standards, those reported previously [18–20], and the theoretical full mass and MS/MS.…”

Section: Resultsmentioning

confidence: 99%

“…The goal was to determine the constituents in the tea, after extraction in hot water as was done for consumption. The techniques employed were liquid chromatography tandem mass spectrometry (LC-MS/MS) and high performance liquid chromatography (HPLC) using conditions similar to those described by others [17–20]. The methodologies used and the experimental data are reported in the Appendix.…”

Section: Presentation Of Casementioning

confidence: 99%

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A Possible Effect of Concentrated Oolong Tea Causing Transient Ischemic Attack-Like Symptoms

Layher

Poling²,

Ishihara

et al. 2013

BJMMR

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AimsTea (green, oolong, and black) is the second most widely consumed beverage worldwide, second only to water. Aside from a few reported adverse effects, tea, particularly green tea, appears to be beneficial for human health. In the case described herein, a male experienced several transient ischemic attack-like symptoms immediately following the consumption of a cup of high quality oolong tea. A thorough medical evaluation uncovered no evidence of such an attack and leads to the suggestion of a heretofore unreported response to oolong tea.Presentation of CaseA 72-year old male with hypertension and atrial fibrillation, who takes valsartan/hydrochlorothiazide to control hypertension and warfarin to reduce the risk of thrombosis and thromboembolism, presented at the emergency room of a local hospital describing several transient ischemic attack-like symptoms immediately after consuming a cup of oolong tea. His symptoms included presyncope, disequilibrium, bilateral hand parathesias, mild dysphasia, and visual problems (but apparently not presbyopia or amaurosis fugax), all of which had disappeared in approximately two hours after drinking the tea. (Mild presyncope was previously noted by the patient when ingesting a strong green tea.) No unusual features emerged from his physical examination, and his blood work was unremarkable except for elevation of his partial thromboplastin time (39 sec) and prothrombin time (22.5 sec), giving an international reference of 2.0, all consistent with the effects of warfarin. A battery of tests by the emergency room physician, a cardiologist, and a neurologist, e.g. electrocardiogram, brain computerized tomography, 2-dimensional transthoracic echocardiogram, brain magnetic resonance imaging, with and without 20 ml Gadolinium, and a magnetic resonance angiogram, confirmed the earlier diagnosis of atrial fibrillation but disclosed no additional malfunction in his heart. His brain showed no evidence of a prior hemorrhage, and his carotid arteries were clear.Methodology and ResultsAnalysis of the oolong tea by high performance liquid chromatography and mass spectrometry identified the major catechins and two methylxanthines, caffeine and theophylline, as well as other constituents, but there was no evidence of any extraneous chemicals that could lead to the symptoms.ConclusionIn view of the rapid onset of symptoms after the consumption of oolong tea, bilateral as opposed to unilateral parathesis, and the absence of any evidence of a hemorrhage or the presence of impurities in the tea, we suggest that the transient ischemic attack-like symptoms could possibly be attributable to one or more components of the oolong tea and was not an atypical magnetic resonance imaging-negative transient ischemic attack.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Presentation Of Casementioning

confidence: 99%

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A Possible Effect of Concentrated Oolong Tea Causing Transient Ischemic Attack-Like Symptoms

Layher

Poling²,

Ishihara

et al. 2013

BJMMR

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“…The variety of flavonoid aglycone and/or glycosyl groups, as well as their linkage challenges precise identification by LC-MS. Kite et al thoroughly investigated fragmentation pattern of flavonoids on LTQ Orbitrap [93,94]. One example is the accurate identification of common isomeric glycosyl groups of flavonoid O-linked di-or tri-saccharides by analyzing the fragmentation of [M + Na] + of glycosyl groups following serial low-energy collision [93].…”

Section: Phenols and Flavonoidsmentioning

confidence: 99%

“…On the basis of high-resolution MS n (n = 3 or 4 for diglycosides and triglycosides, respectively) spectra, isomeric flavonoid di-and triglycosides were differentiated. Another example is the analysis of acylated flavonol tri-and tetra-glycosides [94]. Eighteen non-acylated flavonoid glycosides in crude extracts of leaves of Cladrastis kentukea (Leguminosae) were identified by comparison of chromatographic retention times and mass spectra with those reported in the literature and the structures of 18 acylated flavonoids were tentatively elucidated based on MS n (n = 5) spectral analysis.…”

Section: Phenols and Flavonoidsmentioning

confidence: 99%

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

Guo

Chen

et al. 2013

Journal of Pharmaceutical and Biomedical Analysis

166

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Phytochemical Characterisation of Green Beans (Phaseolus vulgaris L.) by Using High‐performance Liquid Chromatography Coupled with Time‐of‐flight Mass Spectrometry

Abu‐Reidah

Arráez‐Román

Lozano‐Sánchez

et al. 2012

Phytochemical Analysis

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The phytochemical composition of three different varieties of P. vulgaris L have been characterised using HPLC-ESI-TOF-MS. A total of 72 phytochemical compounds were characterised, 54 being reported in green beans for the first time. Among these were the main flavonoids detected. These results highlight the influence that variety can exert on the quality of phytochemicals. Given that new phytochemical compounds have been characterised, this study offers a useful approach for improving and updating the food-composition tables.

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Acylated flavonol tri- and tetraglycosides in the flavonoid metabolome of Cladrastis kentukea (Leguminosae)

Cited by 22 publications

References 11 publications

A Possible Effect of Concentrated Oolong Tea Causing Transient Ischemic Attack-Like Symptoms

A Possible Effect of Concentrated Oolong Tea Causing Transient Ischemic Attack-Like Symptoms

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

Phytochemical Characterisation of Green Beans (Phaseolus vulgaris L.) by Using High‐performance Liquid Chromatography Coupled with Time‐of‐flight Mass Spectrometry

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