Acylation of Amines with 5-Phenyltetrazol-2-ylacetyl Chloride

Putis, S. M.; Zubarev, V. Yu.; Poplavskii, V. S.; Островский, В. А.

doi:10.1023/b:cohc.0000044567.39872.b0

Cited by 6 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A mixture of 5-phenyltetrazol-2-ylacetic acid (1.25 g, 6.1 mmol) and PCl 5 (1.5 g, 7.4 mmol) in benzene (10 ml) was heated to 60ºC and held until hydrogen chloride evolution had ceased and the starting acid had dissolved. After distillation of solvent and liquid products in vacuo on a water pump the dry residue was recrystallized from hexane to give colorless needle-like crystals of the acid chloride 1 (1.2 g, 88%) with mp 101°C (mp 103-104ºC [11]). …”

mentioning

confidence: 99%

Synthesis of branched polynuclear 1,3,4-oxadiazoles

Vereshchagin

Verkhozina

Proidakov

et al. 2008

Chem Heterocycl Comp

View full text Add to dashboard Cite

The reaction of 5-substituted mono-and polytetrazoles with heterocyclic acid chlorides and trifluoroacetic acid anhydride gave branched polynuclear 1,3,4-oxadiazole systems.In searches for novel photosensitive [1] and biologically active materials [2-4] a broad series of 1,3,4-oxadiazoles with different substituents on the carbon atoms have been reported. The usual basis for their synthesis is mainly the dehydration of the corresponding acid hydrazides [5]. However, this reaction is done in relatively severe conditions and does not permit preparation of polynuclear systems with different proportions of oxadiazole rings and other heterocycles as substituents on the oxadiazoles. To a certain extent this restriction is N N N N

show abstract

mentioning

confidence: 99%

Synthesis of branched polynuclear 1,3,4-oxadiazoles

Vereshchagin

Verkhozina

Proidakov

et al. 2008

Chem Heterocycl Comp

View full text Add to dashboard Cite

show abstract

Acylation of Amines with 5‐Phenyltetrazol‐2‐ylacetyl Chloride.

et al. 2005

View full text Add to dashboard Cite

Tetrazole derivatives R 0310Acylation of Amines with 5-Phenyltetrazol-2-ylacetyl Chloride. -The acylation of a variety of amines including highly basic amines containing branched substituents and amines with low basicity is readily achieved using 5-phenyltetrazolylacetyl chloride (I). Derivative (IIIg) is used for the convenient synthesis of tritetrazole (IV). -(PUTIS, S. M.; ZUBAREV, V. Y.; POPLAVSKII, V. S.; OSTROVSKII, V. A.; Chem.

show abstract

Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines

Островский

Danagulyan

Нестерова

et al. 2021

Chem Heterocycl Comp

View full text Add to dashboard Cite

Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine.

show abstract

Acylation of Amines with 5-Phenyltetrazol-2-ylacetyl Chloride

Cited by 6 publications

References 2 publications

Synthesis of branched polynuclear 1,3,4-oxadiazoles

Synthesis of branched polynuclear 1,3,4-oxadiazoles

Acylation of Amines with 5‐Phenyltetrazol‐2‐ylacetyl Chloride.

Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines

Contact Info

Product

Resources

About