Adaptation of siblings of female rats given ethanol effect of N-acetyl-L-cysteine

Abstract

Summary. Ethanol administration to female rats before and during pregnancy resulted in decreased number of litters and increased activities of serum GOT, GPT and ALP. The hepatotoxicity of ethanol was indicated by the histological alterations both in the mother and siblings. There was increased levels of tissue lipids in mother and litters born to alcoholic rats. The concentration of TBARS in the liver and kidney were significantly increased in alcohol treated rats and their litters. The activities of the anti-peroxidative enzymes SOD and CAT were decreased on alcohol treatment in female rats. The glutathione content in liver and kidney decreased significantly in litters born to alcoholic rats.We have observed that the treatment with N-acetylcysteine offers protection against the toxic effect of alcohol in female rats during pregnancy and litters born to them. In N-acetylcysteine treated rats the number of litters as well as the average birth weight were close to that of control animals. Nacetylcysteine decreases the activities of serum GOT, GPT and ALP in female rats. We have also observed decreased levels of tissue lipids in mother and litters born to alcoholic rats given N-acetylcysteine when compared to alcoholic rats. The levels of TBARS in liver, kidney were also decreased both in mother and litter born to alcohol + N-acetylcysteine, while the activities of SOD and CAT were increased in liver of alcoholic rats given N-acetylcysteine when compared to alcoholic rats. Histopathological studies also showed the protective effect of N-acetylcysteine in both mother and litter in liver and kidney against alcoholic induced toxicity.

Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment

“…Significantly low activity of plasma LPL in ethanol-fed rats, as seen in our study, can cause the accumulation of TGs. Our observation agrees with those of previous researchers (Rajakrishnan et al 1997). The hypertriglyceridaemia, increased VLDL-C and increased LDL-C that occurred in the ethanol-fed rats was not observed when the rats were simultaneously treated with HMBA.…”

Protective effect of glycine supplementation on the levels of lipid peroxidation and antioxidant enzymes in the erythrocyte of rats with alcohol‐induced liver injury

“…These results are in line with previous findings, which showed decreased hepatic SOD and CAT levels in alcoholfed rats. 33 The inhibition of SOD and CAT activities by ethanol may cause the accumulation of highly reactive oxygen species such as H 2 O 2 and superoxide radical. 34 The decrease in lipid peroxidation in the erythrocyte membrane, plasma and hepatocytes following treatment with glycine can also be correlated with the elevated SOD and CAT activities.…”

Influence of a thiazole derivative on ethanol and thermally oxidized sunflower oil‐induced oxidative stress

“… : Control rats fed standard pellet diet; : Rats fed 20% ethanol (equivalent to 7.9 g ethanol/kg bw) daily using an intragastric tube [13]. : Rats fed DA (10 mg/kg bw) orally. : Rats fed thermally oxidized sunflower oil (15%) mixed with diet. : Rats fed DA (10 mg/kg bw) + thermally oxidized sunflower oil (15%). : Rats fed 20% ethanol + thermally oxidized sunflower oil (15%). : Rats fed 20% ethanol + DA (10 mg/kg bw). : Rats fed 20% ethanol + thermally oxidized sunflower oil (15%) + DA (10 mg/kg bw). …”

“…The animals were randomized into the following groups: Group 1: Control rats fed standard pellet diet; Group 2: Rats fed 20% ethanol (equivalent to 7.9 g ethanol/kg bw) daily using an intragastric tube [13]. Group 3: Rats fed DA (10 mg/kg bw) orally.…”