“…This is a standard inverse problem, and many methods for finding solutions to this problem have been developed to date (sensitivity functions [20], splines [6], interval analysis [15], adaptive observers [19], [5], [9], [12], [24], [25], [8] and particle filters and Bayesian inference methods [1]). Despite these methods are based on different mathematical frameworks, they share a common feature: one is generally required to repeatedly find numerical solutions of nonlinear ordinary differential equations (ODEs) over given intervals of time (solve the direct problem).…”