Adaptive ranging for optical coherence tomography

Iftimia, Nicusor; Bouma, Brett E.; Boer, Johannes F. de; Park, B. H.; Cense, Barry; Tearney, Guillermo J.

doi:10.1364/opex.12.004025

Cited by 39 publications

(29 citation statements)

References 23 publications

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“…In addition, current systems suffer from limited ranging depth over which the returning signal can be measured, which would make it difficult for one to visualize the entire coronary circumference when the catheter is located eccentrically within the vessel lumen. Adaptive auto-ranging techniques have been suggested as a solution, by the adaptive readjustment of the reference arm galvanometer's position to follow the lumen's curvature [40]. New-generation systems are being developed that have greater ranging depth, which overcomes this problem [39].…”

Section: Psoct: Current Technology Challengesmentioning

confidence: 99%

Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods

et al. 2008

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Acute coronary events such as myocardial infarction are frequently caused by the rupture of unstable atherosclerotic plaque. Collagen plays a key role in determining plaque stability. Methods to measure plaque collagen content are invaluable in detecting unstable atherosclerotic plaques. Recently, novel coherent laser-based imaging techniques, such as polarization-sensitive optical coherence tomography (PSOCT) and laser speckle imaging (LSI) have been investigated, and they provide a wealth of information related to collagen content and plaque stability. Additionally, given their potential for intravascular use, these technologies will be invaluable for improving our understanding of the natural history of plaque development and rupture and, hence, enable the detection of unstable plaques. In this article we review recent developments in these techniques and potential challenges in translating these methods into intra-arterial use in patients.

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Section: Psoct: Current Technology Challengesmentioning

confidence: 99%

Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods

et al. 2008

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“…By using the feedback control the probe is able to track the sample surface variance and the effective imaging depth was largely extended to the probe's free-moving range. The surface location algorithm in reference [9] and [10] is based on the first and second moment calculation of the A-scan data, which depends much on the gain factor distribution inside the sample and cannot get the accurate surface position. Compared to moment calculation, edge-searching method gives much more accurate surface location and thus better for clinic applications such as interventional ophthalmic microsurgery.…”

Section: Self-adaptive Cp-fdoctmentioning

confidence: 99%

“…Using this method, other groups have measured the SO 2 of human blood sample ex vivo [6] and in retina in vivo [7] in real time. Current OCT systems generally suffer from very limited imaging depth range of only 1~3mm, which restricts its clinical applications when the sample surface variance exceeds the imaging depth range [8][9]. One efficient way out is to use adaptive ranging to search the sample surface and then feed the information back to adjust the coherence gate and range on the reference arm [9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Current OCT systems generally suffer from very limited imaging depth range of only 1~3mm, which restricts its clinical applications when the sample surface variance exceeds the imaging depth range [8][9]. One efficient way out is to use adaptive ranging to search the sample surface and then feed the information back to adjust the coherence gate and range on the reference arm [9][10]. For a common-path OCT system, the reference and sample signals share the same path so that the reference offset can be changed directly by adjusting the distance between the fiber probe and the sample surface.…”

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confidence: 99%

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Common-path Fourier-domain optical coherence tomography with a fiber optic probe integrated into a surgical needle

Han

Balicki

Zhang

et al. 2009

Conference on Lasers and Electro-Optics/International Quantum Electronics Conference

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Abstract-We have demonstrated in vivo three-dimensional imaging and estimated localized and quantitative hemoglobin oxygen saturation (SO 2 ) of blood vessel by using a simple, easy to operate common-path Fourier-domain optical coherence tomography (OCT) system. The common-path OCT system can be easily integrated with various surgical tools and we demonstrated its usefulness by imaging outer and inner intraocular tissues such as cornea and neurosensory retinal layers as well as detecting SO 2 level from a chicken embryo. The system uses 800nm near infrared broadband light sources and has axial resolution as low as 3μm in air. Self-adaptive scanning mechanism with real-time surface recognition and feedback control was also applied to the probe where the scanning probe tracks the sample surface variance and effective imaging depth was largely extended to the probe's free-moving range. I. INTRODUCTIONOptical coherence tomography (OCT) is one optical tomography modalit in which ballistic photons are detected rather than projecting the noncoherent photons having diffuse reflection or transmittance for achieving three dimensional images. OCT has unprecedented resolution compared to other imaging modalities such as ultrasound, X-ray computed tomography (CT), and Magnetic Resonance Imaging (MRI), because the axial (or longitudinal) resolution of OCT is determined by the coherence length of the source used which is inversely proportional to the source bandwidth [1].Unlike the conventional OCT systems that use Michelson Interferometers, this work is based on common-path Fourier-domain OCT (CP-FDOCT) which we believe is the one of the simplest, most versatile three dimensional imaging technique available and allows attachment of different kinds of probes [2]. This is possible since the scanning probe provides the reference and also serves as the transceiver. This configuration allows one to use arbitrary length of probe arm and also allows different probe attachments. Moreover, it doesn't have the problem of polarization and dispersion mismatch [3]. It is known that Fourier-domain (FD) systems are simpler, faster and better than that of time-domain (TD) systems since there is no need for mechanically A-scan. CP-FDOCT can be especially useful for ophthalmic applications [4], since the fiber optic probe can easily be integrated or attached to surgical tools and directly inserted into or placed in close proximity to the ocular tissues for image acquisition and surgical navigation for in-situ or in-vivo operation. Furthermore, the level of the hemoglobin (Hb) oxygen saturation (SO 2 ) can be easily obtained by measuring Hb and HbO 2 induced attenuation. Specifically, the SO 2 level was estimated from their spectral absorption characteristics by analyzing signal spectra [5]. Using this method, other groups have measured the SO 2 of human blood sample ex vivo [6] and in retina in vivo [7] in real time. Current OCT systems generally suffer from very limited imaging depth range of only 1~3mm, which restricts its clinical applicati...

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“…An adaptive ranging technique [10] was previously developed to adjust the coherence gate offset within a lateral scan (frame) for a time-domain OCT (TD-OCT) system. As TD-OCT systems are relatively slow compared to SD-OCT systems, it was possible to correct for depth shifts in between A-lines.…”

Section: Introductionmentioning

confidence: 99%

Three dimensional tracking for volumetric spectral-domain optical coherence tomography

Maguluri¹,

Mujat²,

Park³

et al. 2007

Opt. Express

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Abstract:We present a three-dimensional (3D) tracker for a clinical ophthalmic spectral domain optical coherence tomography (SD-OCT) system that combines depth-tracking with lateral tracking, providing a stabilized reference frame for 3D data recording and post acquisition analysis. The depth-tracking system is implemented through a real-time dynamic feedback mechanism to compensate for motion artifact in the axial direction. Active monitoring of the retina and adapting the reference arm of the interferometer allowed the whole thickness of the retina to be stabilized to within ±100 µm. We achieve a relatively constant SNR from image to image by stabilizing the image of the retina with respect to the depth dependent sensitivity of SD-OCT. The depth tracking range of our system is 5.2 mm in air and the depth is adjusted every frame. Enhancement in the stability of the images with the depth-tracking algorithm is demonstrated on a healthy volunteer.

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Adaptive ranging for optical coherence tomography

Cited by 39 publications

References 23 publications

Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods

Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods

Common-path Fourier-domain optical coherence tomography with a fiber optic probe integrated into a surgical needle

Three dimensional tracking for volumetric spectral-domain optical coherence tomography

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