Addendum

Sakurai, Takeshi; Amemiya, Akira; Ishii, Makoto; Matsuzaki, Ichiyo; Chemelli, Richard M.; Tanaka, Hirokazu; Williams, S.Clay; Richardson, James A.; Kozlowski, Gerald P.; Wilson, Shelagh; Arch, Jonathan R.S.; Buckingham, Robin E.; Haynes, Andrea; Carr, Steven A.; Annan, Roland S.; McNulty, Dean E.; Liu, Wu-Schyong; Terrett, Jonathan; Elshourbagy, Nabil A.; Bergsma, Derk J.; Yanagisawa, Masashi

doi:10.1016/s0092-8674(02)09256-5

Cited by 123 publications

(154 citation statements)

References 0 publications

Supporting

Mentioning

147

Contrasting

Order By: Relevance

“…We also found in this study that sleep-deprivation increased c-Fos expression in the hypothalamus. It is well known that the lateral hypothalamus, where histamine and orexin neurons are localized, is involved in feeding behavior (24,38). In addition, previous studies have shown that hypothalamic neurons are glucose-sensitive neurons that can be activated by glucopenia and thus are implicated in the positive short-term regulation of feeding and energy expenditure (39).…”

Section: Discussionmentioning

confidence: 99%

“…Another important neuropeptide in the hypothalamus is orexin (23,24). Orexin neurons are known to be located in the sub-regions of the hypothalamus, such as the perifornical nucleus, lateral hypothalamic area, dorsomedial hypothalamic nucleus, and posterior hypothalamus area, and their fibers overlap in part with histaminergic fibers (25,26).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats

Sakurai

Kuramasu

et al. 2010

J Pharmacol Sci

View full text Add to dashboard Cite

Abstract. Sleep deprivation induces several negative effects on behavior, emotion, attention, and learning ability. Sleep appears to be particularly important during adolescent brain development. In the present study, we examined the effects of sleep deprivation on behavior and hypothalamic neurotransmission including histamine and orexin neurons in adolescent rats using the treadmill method. Adolescent male rats were divided into three groups: treadmill sleep-deprived, treadmill control, and cage control groups. Energy expenditure, anxiety-like behavior, and locomotor activity were examined among the three groups. Histamine concentration in the cortex and diencephalon and the number of c-Fos-positive neurons in the hypothalamus were also examined. In addition, histamine and orexin neurons in the hypothalamus were simultaneously identified using rat histidine decarboxylase and orexin-A immunohistochemistry, respectively. Both energy expenditure and anxiety-related behavior significantly increased by the experimental 3-day sleep deprivation, while exploratory locomotor activity significantly decreased. Histamine contents did not change in the cortex, but significantly decreased in the diencephalon of sleep-deprived rats. Increased expression of c-Fos-positive neurons, including subgroup histamine and orexin neurons, was observed in the hypothalamus. These findings indicate that sleep deprivation increases energy expenditure and anxiety in adolescent rats and provide evidence for the pivotal role of hypothalamus subgroup histamine and orexin neurons in the behavioral response to sleep deprivation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats

Sakurai

Kuramasu

et al. 2010

J Pharmacol Sci

View full text Add to dashboard Cite

show abstract

“…Orexin is synthesized in the lateral hypothalamic area, with projections throughout the hypothalamus and the rest of the brain (de Lecea et al, 1998;Sakurai et al, 1998). There are two orexin receptors, also distributed throughout the brain (Sakurai et al, 1998;Trivedi et al, 1998).…”

Section: Neurobiology Of Spa and Neatmentioning

confidence: 99%

The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives

Garland

Schutz

Chappell

et al. 2011

Journal of Experimental Biology

382

434

View full text Add to dashboard Cite

Summary Mammals expend energy in many ways, including basic cellular maintenance and repair, digestion, thermoregulation, locomotion, growth and reproduction. These processes can vary tremendously among species and individuals, potentially leading to large variation in daily energy expenditure (DEE). Locomotor energy costs can be substantial for large-bodied species and those with high-activity lifestyles. For humans in industrialized societies, locomotion necessary for daily activities is often relatively low, so it has been presumed that activity energy expenditure and DEE are lower than in our ancestors. Whether this is true and has contributed to a rise in obesity is controversial. In humans, much attention has centered on spontaneous physical activity (SPA) or non-exercise activity thermogenesis (NEAT), the latter sometimes defined so broadly as to include all energy expended due to activity, exclusive of volitional exercise. Given that most people in Western societies engage in little voluntary exercise, increasing NEAT may be an effective way to maintain DEE and combat overweight and obesity. One way to promote NEAT is to decrease the amount of time spent on sedentary behaviours (e.g. watching television). The effects of voluntary exercise on other components of physical activity are highly variable in humans, partly as a function of age, and have rarely been studied in rodents. However, most rodent studies indicate that food consumption increases in the presence of wheels; therefore, other aspects of physical activity are not reduced enough to compensate for the energetic cost of wheel running. Most rodent studies also show negative effects of wheel access on body fat, especially in males. Sedentary behaviours per se have not been studied in rodents in relation to obesity. Several lines of evidence demonstrate the important role of dopamine, in addition to other neural signaling networks (e.g. the endocannabinoid system), in the control of voluntary exercise. A largely separate literature points to a key role for orexins in SPA and NEAT. Brain reward centers are involved in both types of physical activities and eating behaviours, likely leading to complex interactions. Moreover, voluntary exercise and, possibly, eating can be addictive. A growing body of research considers the relationships between personality traits and physical activity, appetite, obesity and other aspects of physical and mental health. Future studies should explore the neurobiology, endocrinology and genetics of physical activity and sedentary behaviour by examining key brain areas, neurotransmitters and hormones involved in motivation, reward and/or the regulation of energy balance.

show abstract

“…Another example of intricate complexity present in MAPK activation is constituted by orexin A and orexin B, two hypothalamic peptides, which originate from posttranslational cleavage of a common precursor (Sakurai et al 1998). Orexin A exerted proliferative effects in cultured rat adrenocortical cells whereas orexin B showed antiproliferative effects in the same experimental system (Spinazzi et al 2005).…”

Section: Effectors Of Erk1/2 Activation In Adrenocortical Cellsmentioning

confidence: 99%

Mechanisms of adrenal gland growth: signal integration by extracellular signal regulated kinases1/2

Hoeflich¹,

Bielohuby²

2008

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

The adrenal gland influences a multitude of processes during stress response, but also potently affects the immune system, glucose metabolism, electrolyte or water homeostasis, and cardiovascular functions. According to the present understanding, the adrenal cortex is tightly controlled by the hypothalamic-pituitary-adrenal axis. This axis involves hypothalamic CRH and pituitary ACTH which determine processes of adrenocortical growth and function. However, control of the adrenal gland comprises a plethora of additional endogenous or exogenous factors. Among those are diverse hormones, psychosocial parameters, physiological stress, secondary plant products, or even environmental pollutants. In the present review, we summarize the current view of endocrine growth control in the adrenal gland. We then discuss intracellular mechanisms of adrenal growth control and focus on extracellular signal regulated kinases 1/2 ( ERK1/2), which have been demonstrated to be controlled by not only ACTH or angiotensin II, but also by a large number of additional effectors. On the basis of these multiple exogenous or endogenous factors which impact on the adrenal gland through ERK1/2 activity, we speculate on a mechanism by which ERK1/2 act as a central integrative growth regulatory elements in the adrenal gland.

show abstract

Addendum

Cited by 123 publications

References 0 publications

Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats

Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats

The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives

Mechanisms of adrenal gland growth: signal integration by extracellular signal regulated kinases1/2

Contact Info

Product

Resources

About